Zobrazeno 1 - 10 of 66 pro vyhledávání: '"C R Middaugh"'
1
Interaction of Partially Structured States of Acidic Fibroblast Growth Factor with Phospholipid Membranes
Autor: Henryk Mach, C R Middaugh
Publikováno v: Biochemistry. 34:9913-9920
Although acidic fibroblast growth factor (aFGF) lacks a conventional signal sequence, it is often found complexed to sulfated proteoglycans on the external surface of cells. The protein also forms a "molten globule"-like state at neutral pH and physi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bbbb1a1eb20c457bcc9b85ff6d94046
https://doi.org/10.1021/bi00031a013
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2
Simultaneous Monitoring of the Environment of Tryptophan, Tyrosine, and Phenylalanine Residues in Proteins by Near-Ultraviolet Second-Derivative Spectroscopy
Autor: C R Middaugh, Henryk Mach
Publikováno v: Analytical Biochemistry. 222:323-331
A method for deconvolution of the near-uv second-derivative spectra of proteins into their component tryptophan, tyrosine, and phenylalanine spectra is described. In this approach, the second-derivative spectra of tryptophan and tyrosine model compou
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a239d397324c663c157695634e139eb8
https://doi.org/10.1006/abio.1994.1499
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3
Bacteriophage T7 RNA Polymerase and Its Active-site Mutants
Autor: D. B. Volkin, Narasimha Sreerama, Patricia A. Osumi-Davis, A-Young M. Woody, Robert W. Woody, C. R. Middaugh
Publikováno v: Journal of Molecular Biology. 237:5-19
It has been demonstrated that the amino acids Asp537, Asp812, Lys631, His811 and Tyr639 are involved in bacteriophage T7 RNA polymerase catalysis. In the present paper, we report kinetic, spectroscopic and calorimetric characterization of the wild-ty
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7af1816006de74a8307bae760a368f80
https://doi.org/10.1006/jmbi.1994.1205
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4
Sucralfate and soluble sucrose octasulfate bind and stabilize acidic fibroblast growth factor
Autor: C J Burke, C R Middaugh, Henryk Mach, David B. Volkin, A M Verticelli, Kimberly E. Marfia
Publikováno v: Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1203:18-26
The actions of the anti-ulcer drug sucralfate have been proposed to be mediated through interaction with fibroblast growth factors (Folkman, J., Szabo, S., Strovroff, M., McNeil, P., Li, W. and Shing, Y. (1991) Ann. Surg. 214, 414-427). We show here
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc469f2d6cbb0233f464259735e0ac04
https://doi.org/10.1016/0167-4838(93)90031-l
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5
Structure of synthetic peptide analogues of an eggshell protein ofSchistosoma mansoni
Autor: C J Burke, H Ji, Henryk Mach, C R Middaugh, Steven M. Pitzenberger, James A. Ryan, Adel M. Naylor, John A. Thomson, Michael J. Bogusky, John S. Cordingley
Publikováno v: Protein Science. 2:900-914
The peptide (Gly-L-Tyr-L-Asp-L-Lys-L-Tyr)6, referred to as F4-6, was synthesized as a model for a schistosome eggshell protein in which the Gly-Tyr-Asp-Lys-Tyr consensus sequence is repeated over 40 times. Analysis by CD, Fourier transform infrared s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d189a831586e9df1eac57a09ae36ba7
https://doi.org/10.1002/pro.5560020604
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6
[Untitled]
Autor: J O Gress, J M Dabora, P. K. Tsai, Mark W. Bruner, M Keogan, David B. Volkin, C R Middaugh, Bozena Matuszewska, Joseph V. Bondi, K C Thompson
Publikováno v: Pharmaceutical Research. 10:649-659
The design of an aqueous formulation for acidic fibroblast growth factor (aFGF) requires an understanding of the type of compounds that can either directly or indirectly stabilize the protein. To this end, spectrophotometric turbidity measurements we
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c52000a82e968778df3220f24748db26
https://doi.org/10.1023/a:1018939228201
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8
Structural implications of spectroscopic characterization of a putative zinc finger peptide from HIV-1 integrase
Autor: A S Zeft, Mark W. Bruner, Gautam Sanyal, James A. Ryan, H L Robbins, C R Middaugh, C J Burke, Robert L. Lafemina, M G Cordingley
Publikováno v: Journal of Biological Chemistry. 267:9639-9644
The N-terminal domain of human immunodeficiency virus (HIV-1) integrase (IN) contains the sequence motif His-Xaa3-His-Xaa23-Cys-Xaa2-Cys, which is strongly conserved in all retroviral and retrotransposon IN proteins. This structural motif constitutes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b35d979b679b0461c64bc40faf2660a
https://doi.org/10.1016/s0021-9258(19)50138-7
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9
Effect of polyanions on the refolding of human acidic fibroblast growth factor
Autor: C. R. Middaugh, Gautam Sanyal, J M Dabora
Publikováno v: Journal of Biological Chemistry. 266:23637-23640
Acidic fibroblast growth factor (aFGF) is unstable at physiological temperatures in the absence of polyanions such as heparin. Therefore, the effect of temperature on the kinetics of refolding of aFGF has been examined in the presence and absence of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99b237a49ce3721d8b1d9ec46fbd80a1
https://doi.org/10.1016/s0021-9258(18)54331-3
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10
Inhibition of alpha-crystallin aggregation by gamma-crystallin
Autor: Randolph V. Lewis, H Mach, John A. Thomson, C R Middaugh, P A Trautman
Publikováno v: Journal of Biological Chemistry. 265:4844-4848
The transparency of the mammalian lens is primarily maintained by short range order among the major proteins of the lens fiber cells, the crystallins. Although these proteins are highly conserved at the amino acid sequence level, it has proven diffic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40ed20199e4f3e314b7c793d4d921aa7
https://doi.org/10.1016/s0021-9258(19)34050-5
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