Zobrazeno 1 - 10 of 41 pro vyhledávání: '"C R Hopkins"'
1
Structural basis of tankyrase activation by polymerization
Autor: Nisha Pillay, Laura Mariotti, Mariola Zaleska, Oviya Inian, Matthew Jessop, Sam Hibbs, Ambroise Desfosses, Paul C. R. Hopkins, Catherine M. Templeton, Fabienne Beuron, Edward P. Morris, Sebastian Guettler
Publikováno v: Nature
Nature, 2022, 612 (7938), pp.162-169. ⟨10.1038/s41586-022-05449-8⟩
The poly-ADP-ribosyltransferase tankyrase (TNKS, TNKS2) controls a wide range of disease-relevant cellular processes, including WNT–β-catenin signalling, telomere length maintenance, Hippo signalling, DNA damage repair and glucose homeostasis1,2.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccbf5494b760f8ef8193e02877b4ab33
https://hal.science/hal-03967132
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2
Akademický článek
Neurodegeneration in a Drosophila model for the function of TMCC2, an amyloid protein precursor-interacting and apolipoprotein E-binding protein.
Autor: Paul C R Hopkins
Publikováno v: PLoS ONE, Vol 8, Iss 2, p e55810 (2013)
We previously identified TMCC2 as a protein that interacted differentially with normal versus Alzheimer's disease-risk forms of both apolipoprotein E (apoE) and the amyloid protein precursor (APP). We hypothesized that disrupted function of TMCC2 wou
Externí odkaz: https://doaj.org/article/c962d9e8eceb4db392de0c5a44c4a658
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3
The Impact of a Novel Apolipoprotein E and Amyloid-β Protein Precursor-Interacting Protein on the Production of Amyloid-β
Autor: Paul C R Hopkins, Ricardo Sainz-Fuertes, Simon Lovestone
Publikováno v: Journal of Alzheimer's Disease. 26:239-253
Alzheimer's disease (AD) is characterized by disrupted metabolism of the amyloid-β protein precursor (AβPP) and deposition of a byproduct, the amyloid-β (Aβ) peptide, into plaques. AD is also genetically linked to the gene for apolipoprotein E (a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eb39cc2a5e9e770822c89684db56ca3
https://doi.org/10.3233/jad-2011-102115
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4
Egg resorption in Nasonia vitripennis (Walker) (Hymenoptera: Pteromalidae)
Autor: C. R. Hopkins, P. E. King
Publikováno v: Proceedings of the Royal Entomological Society of London. Series A, General Entomology. 39:101-107
SYNOPSIS Egg resorption in Nasonia vitripennis, a parasite on the pupal stage of muscoid flies, was investigated histochemically and the changes in the carbohydrates, nucleic acids, protems and lipies of the egg yolk are described. Three types of yol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9eb9d5bd826a8d9fa270cc8080de516d
https://doi.org/10.1111/j.1365-3032.1964.tb00795.x
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5
Thyroid and parathyroid imaging
Autor: Carl C. Reading, C R Hopkins
Publikováno v: Seminars in Ultrasound, CT and MRI. 16:279-295
This article reviews the current roles of imaging in the diagnosis of thyroid and parathyroid disorders, with an emphasis on ultrasound evaluation. Imaging of the thyroid and parathyroid can be performed with nuclear medicine, ultrasound, CT, and MRI
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39912d995f4704f21257c50b197ad40b
https://doi.org/10.1016/0887-2171(95)90033-0
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6
Sorting signals in the MHC class II invariant chain cytoplasmic tail and transmembrane region determine trafficking to an endocytic processing compartment
Autor: C. R. Hopkins, Ian S. Trowbridge, Luzheng Xue, James F. Collawn, C. D. Davis, C. G. Odorizzi
Publikováno v: The Journal of Cell Biology
Targeting of MHC class II molecules to the endocytic compartment where they encounter processed antigen is determined by the invariant chain (Ii). By analysis of Ii-transferrin receptor (TR) chimera trafficking, we have identified sorting signals in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::649d96b3f113fff90a847af3e621f49a
https://doi.org/10.1083/jcb.126.2.317
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8
Role of the human transferrin receptor cytoplasmic domain in endocytosis: localization of a specific signal sequence for internalization
Autor: Ian S. Trowbridge, Terry Spencer, C. R. Hopkins, Shuqian Jing, Karen Miller
Publikováno v: The Journal of Cell Biology
Wild-type and mutant human transferrin receptors have been expressed in chicken embryo fibroblasts using a helper-independent retroviral vector. The internalization of mutant human transferrin receptors, in which all but four of the 61 amino acids of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a39136dda0feb95dbde815adf6e82fb
http://europepmc.org/articles/PMC2116009
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10
Apical and basolateral endosomes of MDCK cells are interconnected and contain a polarized sorting mechanism
Autor: Derrick L. Domingo, C. R. Hopkins, Greg Odorizzi, Adele Pearse, Ian S. Trowbridge
Publikováno v: The Journal of Cell Biology
We have evaluated transcytotic routes in MDCK cells for their ability to generate a polarized surface distribution of trafficking proteins by following the intracellular sorting of transferrin receptors (TRs). We find that the selective basolateral e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6edcb67dba6c1783d2cd94f01ddae33f
https://pubmed.ncbi.nlm.nih.gov/8858169
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