Neuronale Korrelate von Cue-Reactivity bei Personen mit Smartphonesucht

Autor: M M Schmitgen, J Horvath, C Mundinger, D N Wolf, F Sambataro, D Hirjak, M K Kubera, J Koenig, C R Wolf

Publikováno v: Suchttherapie.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51073704483c916774f74039955a71fd
https://doi.org/10.1055/s-0042-1756047

An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials

Autor: C J, Henderson, Y, Kapelyukh, N, Scheer, A, Rode, A W, McLaren, A K, MacLeod, D, Lin, J, Wright, L A, Stanley, C R, Wolf

Publikováno v: Drug Metabolism and Disposition

Species differences in drug metabolism and disposition can confound the extrapolation of in vivo PK data to man and also profoundly compromise drug efficacy studies owing to differences in pharmacokinetics, in metabolites produced (which are often ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d637b707db56f3717a5fb3bd713f77c4
https://pubmed.ncbi.nlm.nih.gov/30910785

Genetically Humanized Animal Models

Autor: Colin J. Henderson, Ian D. Wilson, Nico Scheer, Kristin Samuelsson, C R Wolf

Genetically humanized mice for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging as promising in vivo models for improved prediction of the pharmacokinetic, drug–drug interaction, and safety ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4afb86886e2d155adcdbad54f49e1532
https://doi.org/10.1016/b978-0-12-409547-2.12376-5

Individuality in FGF1 expression significantly influences platinum resistance and progression-free survival in ovarian cancer

Autor: Gillian Smith, Charlie Gourley, M. T. H. Ng, Michelle Ferguson, C R Wolf, L. Shepherd, C.S. Herrington

Publikováno v: British Journal of Cancer
Smith, G, Ng, M T H, Shepherd, L, Herrington, C S, Gourley, C, Ferguson, M J & Wolf, C R 2012, ' Individuality in FGF1 expression significantly influences platinum resistance and progression-free survival in ovarian cancer ', British Journal of Cancer, vol. 107, no. 8, pp. 1327-36 . https://doi.org/10.1038/bjc.2012.410

BACKGROUND: Ovarian cancer is frequently advanced at presentation when treatment is rarely curative. Response to first-line platinum-based chemotherapy significantly influences survival, but clinical response is unpredictable and is frequently limite

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ebd344e2719c09852f8a4477531cd64
https://doi.org/10.1038/bjc.2012.410

Pyrosequencing-based methods reveal marked inter-individual differences in oncogene mutation burden in human colorectal tumours

Autor: Michael E. Burczynski, F A Carey, G Miele, G Feuerstein, K Walsh, S. Weidlich, C R Wolf, Daniel Crowther, Robert Steele, Gillian Smith

Publikováno v: British Journal of Cancer

Background: The epidermal growth factor receptor-targeted monoclonal antibody cetuximab (Erbitux) was recently introduced for the treatment of metastatic colorectal cancer. Treatment response is dependent on Kirsten-Ras (K-Ras) mutation status, in wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df10237c1e310ae05590112f10f7ebfa
http://europepmc.org/articles/PMC3142798