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Tachyphylactic properties of angiotensin II analogs with bulky and hydrophobic substituents at the N-terminus

Autor: S C, Motta, E F, Poletti, S E G, Souza, S A A, Correa, G N, Jubilut, A C M, Paiva, S I, Shimuta, C R, Nakaie

Publikováno v: The journal of peptide research : official journal of the American Peptide Society. 62(5)

Tachyphylaxis, defined as the acute loss of response of some smooth muscles upon repeated stimulations with angiotensin II (Ang II), has been shown to be dependent mainly on the N-terminal region of the ligand. To further study the structural require

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::38ded2124e3b365c3085912a9e7c354d
https://pubmed.ncbi.nlm.nih.gov/14531846

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Spin-labeled extracellular loop from a seven-transmembrane helix receptor: studies in solution and interaction with model membranes

Autor: T A, Pertinhez, C R, Nakaie, A C, Paiva, S, Schreier

Publikováno v: Biopolymers. 42(7)

A spin-labeled pentadecapeptide was synthesized containing 2,2,6,6-tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid (TOAC) as the N-terminal amino acid and residues 253-266 (EYWSTFGNLHHISL) of the mass oncogene receptor, a membrane-bound protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::421146bcea22f376cc57e949072bbd75
https://pubmed.ncbi.nlm.nih.gov/10904553

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Mapping the domain of troponin T responsible for the activation of actomyosin ATPase activity. Identification of residues involved in binding to actin

Autor: D M, Oliveira, C R, Nakaie, A D, Sousa, C S, Farah, F C, Reinach

Publikováno v: The Journal of biological chemistry. 275(36)

The in vitro Ca(2+) regulation of the actomyosin Mg(2+)-ATPase at physiological ratios of actin, tropomyosin, and troponin occurs only in the presence of troponin T. We have previously demonstrated that a polypeptide corresponding to the first 191 am

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3c889812bf36eb713487d7dac74baa81
https://pubmed.ncbi.nlm.nih.gov/10852909

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First synthesis of a fully active spin-labeled peptide hormone

Autor: S R, Barbosa, E M, Cilli, M T, Lamy-Freund, A M, Castrucci, C R, Nakaie

Publikováno v: FEBS letters. 446(1)

For the first time in the electron spin resonance (ESR) and peptide synthesis fields, a fully active spin-labeled peptide hormone was reported. The ESR spectra of this alpha-melanocyte stimulating hormone (alpha-MSH) analogue (acetyl-Toac0-alpha-MSH)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7044a850ead85db3ae2e458def22b68c
https://pubmed.ncbi.nlm.nih.gov/10100612

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Structure of two fragments of the third cytoplasmic loop of the rat angiotensin II AT1A receptor. Implications with respect to receptor activation and G-protein selection and coupling

Autor: L, Franzoni, G, Nicastro, T A, Pertinhez, E, Oliveira, C R, Nakaie, A C, Paiva, S, Schreier, A, Spisni

Publikováno v: The Journal of biological chemistry. 274(1)

The structural bases that render the third intracellular loop (i3) of the rat angiotensin II AT1A receptor one of the cytoplasmic domains responsible for G-protein coupling are still unknown. The three-dimensional structures of two overlapping peptid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d67a3b72317af0c6dafcd85944332cb6
https://pubmed.ncbi.nlm.nih.gov/9867834

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Binding of peptide fragments from a seven helix membrane receptor to lipid bilayers and to micelles

Autor: T A, Pertinhez-Sini, C R, Nakaie, R S, Carvalho, A C, Paiva, M, Tabak, F, Toma, S, Schreier

Publikováno v: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 27(2)

Membrane proteins influence the organizational and motional properties of lipids, while the conformation and function of these proteins (receptors, channels, enzymes, pumps) are affected by the lipid environment. Model systems consisting of peptides

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6966ba2672492065f9c9704fa5ef491b
https://pubmed.ncbi.nlm.nih.gov/8081278

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Evolution of reactivity of sera from HIV-1 patients to synthetic gp41(598–609) and analogues

Autor: N. F. Mendes, I. M. Longo, A. C. M. Paiva, C. R. Nakaie, T. M. Miranda, H. J. Hernandez, Peixinho Zf

Publikováno v: Peptides 1992 ISBN: 9789401046466
Peptides 1992

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8cecf14ca62c80368bdda1e9b9ff559
https://doi.org/10.1007/978-94-011-1470-7_407

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Correlation between rate of coupling reaction and swelling of resin beads: Influence of solvents, peptide sequence, chaotropic salt and acylation methods

Autor: A. C. M. Paiva, G. N. Jubilut, R. Marchetto, E. Oliveira, C. R. Nakaie

Publikováno v: Peptides ISBN: 9789401050050
Peptides

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3353aea8bf8cf236a5f4e38cce30f5f1
https://doi.org/10.1007/978-94-011-2264-1_222

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Changes in residues 1 and 4 of angiotensin II affect differently its agonist and tachyphylactic properties

Autor: D. Theodoropoulos, Suma I. Shimuta, P. Cordopatis, C. R. Nakaie, Antonio C.M. Paiva

Publikováno v: Naunyn-Schmiedeberg's Archives of Pharmacology. 340

Two series of angiotensin 11 analogues with modifications at positions 1 or 4 of the peptide chain were studied with respect to their tachyphylactic properties and to the kinetics of relaxation of the guinea-pig ileum after a contractile response to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc85ad8173b4f2ffa9c8740aadfd597
https://doi.org/10.1007/bf00168515

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