Výsledky vyhledávání - "C R, Kinsolving"

ChemInform Abstract: Studies on Antifungal Agents. In vitro Activity of Novel cis-5-Alkoxy-(or Acyloxy)alkyl-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidine Derivatives

Autor: S. D. Allen, J. T. Mitchell, V. St. Georgiev, David M. Maryniak, George B. Mullen, C. R. Kinsolving

Publikováno v: ChemInform. 21

The synthesis and in vitro antifungal activity of a novel series of cis-5-alkoxy(or acyloxy)alkyl-3-phenyl-3-(1H-imidazol-1-ylmethyl)- 2-methylisoxazolidine derivatives (6a-n) are described. The 5-[(4-chlorobenzyloxy)methyl] analogue 6h and the two 5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e8391a01f6e741c1b9b27402114bbbc
https://doi.org/10.1002/chin.199023316

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Studies on antifungal agents. In vitro activity of novel cis-5-alkoxy (or acyloxy)alkyl-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidine derivatives

Autor: D M, Maryniak, G B, Mullen, S D, Allen, J T, Mitchell, C R, Kinsolving, V, St Georgiev

Publikováno v: Arzneimittel-Forschung. 40(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::efe184e4c891fc3fbb86f9fcd25885c7
https://pubmed.ncbi.nlm.nih.gov/2340006

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Selection of orally active antifungal agents from 3,5-substituted isoxazolidine derivatives based on acute efficacy-safety profiles

Autor: G. B. Mullen, S. D. Allen, R D Simmons, V St Georgiev, C. R. Kinsolving, M J Ordy, G C Palmer, J C Strand, J T Mitchell, L. A. Radov

Publikováno v: Antimicrobial Agents and Chemotherapy. 33:895-905

Routine in vitro screening of a new synthetic series of 3,5-substituted 2-methylisoxazolidines revealed that three imidazole analogs (PR 967-248, PR 967-234, and PR 969-566) and, to a lesser extent, a triazole analog (PR 988-399) exerted rather poten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cfd91681f2c40f4e7f0f5ef1cf31878
https://doi.org/10.1128/aac.33.6.895

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Tilorone: Its Selective Effects on Humoral and Cell-Mediated Immunity

Autor: I. Shemano, H. Megel, C. R. Kinsolving, S. Goldstein, Michael Jg, A. Raychaudhuri

Publikováno v: Experimental Biology and Medicine. 145:513-518

SummaryWe have shown selective activity of tilorone with regard to humoral and cell-mediated responses. The compound enhanced antibody production as shown by an increase in IgM and IgG antibody-forming cells in the primary and secondary immune respon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::112cf2d6bfa6c1002a98caa7aa6b1cc8
https://doi.org/10.3181/00379727-145-37842

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Flavodilol

Autor: F. C. Kaiser, B. E. Watkins, E. S. C. Wu, A. R. Borrelli, C. R. Kinsolving

Publikováno v: Journal of Cardiovascular Pharmacology. 14:127-141

Flavodilol, a new antihypertensive drug, was evaluated in a variety of test systems for better understanding of its biologic properties and the nature of its mechanism of action. Oral administration of the drug to spontaneously hypertensive rats (SHR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f4a67e9d022e54196a0ee218614e237
https://doi.org/10.1097/00005344-198907000-00022

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Flavodilol: a new antihypertensive agent

Autor: C R, Kinsolving, B E, Watkins, A R, Borrelli, F C, Kaiser, E S, Wu

Publikováno v: Journal of cardiovascular pharmacology. 14(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::740d0ef211d618908ef3a76a69a89077
https://pubmed.ncbi.nlm.nih.gov/2475704

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Studies on antifungal agents. 23. Novel substituted 3,5-diphenyl-3-(1H-imidazol-1-ylmethyl)- 2-alkylisoxazolidine derivatives

Autor: Vassil St. Georgiev, George B. Mullen, DeCory Tr, Mitchell Jt, C. R. Kinsolving, Allen Sd

Publikováno v: Journal of medicinal chemistry. 31(10)

The synthesis and antifungal activity of a novel series of substituted 3,5-diphenyl-3-(1H-imidazol-1-ylmethyl)-2-alkylisoxazolidine derivatives (15-30) are described. The synthesis of the title compounds was accomplished via a 1,3-dipolar cycloadditi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e1242c11c551ed8b951205747e8bf7
https://pubmed.ncbi.nlm.nih.gov/3172137

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