Výsledky vyhledávání

T helper frequencies in peripheral blood reflect donor-directed reactivity in the graft after clinical heart transplantation

Autor: Willem Weimar, Frans H.J. Claas, C. R. Daane, Aggie H.M.M. Balk, Alex P.W.M. Maat, Leonard M.B. Vaessen

Publikováno v: Clinical & Experimental Immunology, 118, 473-479. Wiley-Blackwell Publishing Ltd

SUMMARYWe describe the usefulness of a fast (48-h) limiting dilution assay (LDA) for the enumeration of human alloreactive helper T lymphocytes (HTL) in the peripheral blood, in relation to histologically defined rejection grades after heart transpla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::887c00498709148e9353d864c7bbfadb
https://hdl.handle.net/1765/65164

Zobrazit plný text záznamu

The avidity of allospecific cytotoxic T lymphocytes (CTL) determines their cytokine production profile

Autor: B. Mochtar, W. Weimar, A. H. M. M. Balk, C. J. Knoop, N. E. M. Van Emmerik, L. M. B. Vaessen, F.H.J. Claas, C. J. Hesse, C. R. Daane

Publikováno v: Clinical and Experimental Immunology. 110:447-453

SUMMARY Donor-specific CTL present within the cardiac allograft during a rejection episode are distinct from those that populate the cardiac allograft in the absence of rejection. Whereas the former generally have a high avidity for donor cells, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea18a0b0c489f9031764222b3a8dab4
https://doi.org/10.1046/j.1365-2249.1997.4441458.x

Zobrazit plný text záznamu

DONOR-SPECIFIC CYTOKINE PRODUCTION BY GRAFT-INFILTRATING LYMPHOCYTES INDUCES AND MAINTAINS GRAFT VASCULAR DISEASE IN HUMAN CARDIAC ALLOGRAFTS1

Autor: C. R. Daane, Aggie H.M.M. Balk, Willem Weimar, Bas Mochtar, Lenard M.B. Vaessen, Nicole M. van Besouw

Publikováno v: Transplantation. 63:1313-1318

Background. The development of graft vascular disease (GVD) in the allograft is a major impediment for long-term survival of heart transplant recipients. GVD may be mediated by cellular processes, in response to the transplanted heart, and regulated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8b56d1bf8857c4ce4f60ba51fdb2cc6
https://doi.org/10.1097/00007890-199705150-00020

Zobrazit plný text záznamu

Prophylactic therapy with OKT3 does not affect donor specific reactivity of peripheral blood lymphocytes from heart transplant recipients

Autor: Willem Weimar, B. Mochtar, Aggie H.M.M. Balk, F.H.J. Claas, C. R. Daane, Leonard M.B. Vaessen, P. Heyse, Nicolet H. P. M. Jutte

Publikováno v: Transplant Immunology. 2:22-26

To avoid the nephrotoxic effect of high-dose cyclosporin A (CsA) immediately post-transplant, heart transplant recipients received as prophylactic therapy intravenous OKT3 for seven days instead of intravenous CsA. Patients receiving OKT3 were compar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d06a4f1f95962f976ff0c8c8085771
https://doi.org/10.1016/0966-3274(94)90073-6

Zobrazit plný text záznamu

PERIPHERAL MONITORING OF DIRECT AND INDIRECT ALLOANTIGEN PRESENTATION PATHWAYS IN CLINICAL HEART TRANSPLANT RECIPIENTS1

Autor: Aggie H.M.M. Balk, Nicole M. van Besouw, Nicolet H. P. M. Jutte, Lenard M.B. Vaessen, Willem Weimar, Frans H.J. Claas, C. R. Daane

Publikováno v: Transplantation. 61:165-167

It has been reported that the response to alloantigens presented by the direct and indirect pathway may be of differential relevance after human kidney transplantation. Accordingly, we monitored these routes in peripheral blood mononuclear cells (PBM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8d98684b8dbbb3f2bd27959901e75c0
https://doi.org/10.1097/00007890-199601150-00033

Zobrazit plný text záznamu

Kinetics of circulating cytotoxic T lymphocyte precursors that have a high avidity for donor antigens: correlation with the rejection status of the human cardiac allograft

Autor: Frans H.J. Claas, Nancy E.m. van Emmerik, L. M. B. Vaessen, Aggie H.M.M. Balk, C. R. Daane, Bas Mochtar, Willem Weimar, C. J. Knoop

Publikováno v: Transplant immunology. 6(3)

Studies on graft infiltrating cells demonstrated that accumulation of cytotoxic T lymphocytes (CTL) with high avidity for donor antigens (Ag) coincided with acute cardiac rejection. In the present study, we analyse whether such high-avidity CTL are p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50fccfd70c54460324b6f74b1c4b5f3c
https://pubmed.ncbi.nlm.nih.gov/9848221

Zobrazit plný text záznamu

Donor-specific CTL frequencies in peripheral blood in relation to graft vascular disease after clinical heart transplantation

Autor: A. H. M. M. Balk, L. M. B. Vaessen, P. De Kuiper, B. Mochtar, C. R. Daane, N.M. van Besouw, T. van Gelder, W. Weimar

Publikováno v: Transplant international : official journal of the European Society for Organ Transplantation. 11

Cellular mechanisms may play a role in the development of graft vascular disease (GVD). We previously demonstrated that GVD correlated with an increase of donor-specific T-helper 1 cytokine production by graft-infiltrating lymphocytes but not by peri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a22f8bdf1c330e0db57170bebb6bcbe9
https://pubmed.ncbi.nlm.nih.gov/9665017

Zobrazit plný text záznamu

Donor-specific cytokine production by graft-infiltrating lymphocytes induces and maintains graft vascular disease in human cardiac allografts

Autor: N M, van Besouw, C R, Daane, L M, Vaessen, B, Mochtar, A H, Balk, W, Weimar

Publikováno v: Transplantation. 63(9)

The development of graft vascular disease (GVD) in the allograft is a major impediment for long-term survival of heart transplant recipients. GVD may be mediated by cellular processes, in response to the transplanted heart, and regulated by cytokines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7780905a63c5d3baff91a93d2e18e8bb
https://pubmed.ncbi.nlm.nih.gov/9158027

Zobrazit plný text záznamu

Peripheral monitoring of direct and indirect alloantigen presentation pathways in clinical heart transplant recipients

Autor: N M, van Besouw, L M, Vaessen, C R, Daane, N H, Jutte, A H, Balk, F H, Claas, W, Weimar

Publikováno v: Transplantation. 61(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9367e8702fac1139503b0060c780d18a
https://pubmed.ncbi.nlm.nih.gov/8560560

Zobrazit plný text záznamu

Patterns in donor-specific mRNA and protein production of Th1 and Th2 cytokines by graft-infiltrating lymphocytes and PBMC after heart transplantation

Autor: C C, Baan, N M, van Besouw, C R, Daane, A H, Balk, B, Mochtar, H G, Niesters, W, Weimar

Publikováno v: Transplant international : official journal of the European Society for Organ Transplantation. 9

We used RT-PCR and ELISA to study the kinetics of IL-2 (Th1) and IL-4 (Th2) both on mRNA and protein level from "naive" PBMC and "primed" graft-infiltrating lymphocytes (GIL) obtained from a heart transplant recipient. For this purpose, these cells w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bb57e153a9c568d03df3d6e4583c37d2
https://pubmed.ncbi.nlm.nih.gov/8959837

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání