Výsledky vyhledávání - "C R, Abraham"

AAV‐mediated expression of secreted and transmembrane αKlotho isoforms rescues relevant aging hallmarks in senescent SAMP8 mice

Autor: J. Roig‐Soriano, C. Griñán‐Ferré, J. F. Espinosa‐Parrilla, C. R. Abraham, A. Bosch, M. Pallàs, Miguel Chillón

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona

Senescence represents a stage in life associated with elevated incidence of morbidity and increased risk of mortality due to the accumulation of molecular alterations and tissue dysfunction, promoting a decrease in the organism's protective systems.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b1adcda6e7bd6868abfa2e506ff2bc
https://doi.org/10.1111/acel.13581

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Klotho Is a Neuroprotective and Cognition-Enhancing Protein

Autor: C R, Abraham, P C, Mullen, T, Tucker-Zhou, C D, Chen, E, Zeldich

Publikováno v: Vitamins and hormones. 101

In this chapter, we will describe what has been learned about Klotho and its potential functions in the brain. Klotho is localized in the choroid plexus and, to a lesser extent, in hippocampal neurons. Cognitive decline is a common issue in human agi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fb163db9e4227b3e4c7a4aab82b36abc
https://pubmed.ncbi.nlm.nih.gov/27125744

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Age-dependent myelin degeneration and proteolysis of oligodendrocyte proteins is associated with the activation of calpain-1 in the rhesus monkey

Autor: J A, Sloane, J D, Hinman, M, Lubonia, W, Hollander, C R, Abraham

Publikováno v: Journal of neurochemistry. 84(1)

Myelin provides important insulating properties to axons allowing for propagation of action potentials over large distances at high velocity. Disruption of the myelin sheath could therefore contribute to cognitive impairment, such as that observed du

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::78cafe06b730f4d157f3a751dd62a595
https://pubmed.ncbi.nlm.nih.gov/12485412

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Alpha 1-antichymotrypsin inhibits A beta degradation in vitro and in vivo

Autor: C R, Abraham, W T, McGraw, F, Slot, R, Yamin

Publikováno v: Annals of the New York Academy of Sciences. 920

The neuropathology of Alzheimer's disease (AD) is characterized by extensive deposition of the toxic amyloid beta peptide (A beta) in selected regions of the brain and brain vasculature (Selkoe, 1999). Thus, lowering the levels of A beta may be benef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::88d5887e57651d1f7bf29ad3956baf40
https://pubmed.ncbi.nlm.nih.gov/11193158

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The fibril forming region of the beta-amyloid precursor differs from that of the amyloid A precursor in its interaction with lipids

Autor: J S, Liang, R E, Fine, C R, Abraham, J D, Sipe

Publikováno v: Biochemical and biophysical research communications. 219(3)

Since the amyloid A (AA) precursoir, serum amyloid A (apoSAA), has been shown to bind cholesterol (C) in the AA fibril forming region, we investigated the interaction of the beta-amyloid precursor protein (AbetaPP) and beta-amyloid (Abeta) peptide wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7b161fa3bc92753d283898f9a0dc9c65
https://pubmed.ncbi.nlm.nih.gov/8645287

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Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice

Autor: S M, Toggas, E, Masliah, E M, Rockenstein, G F, Rall, C R, Abraham, L, Mucke

Publikováno v: Nature. 367(6459)

Many people infected with human immunodeficiency virus type 1 (HIV-1) develop neurological complications that can culminate in dementia and paralysis. The discrepancy between the severity of impairment and the paucity of detectable HIV-1 within neuro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::da6baffa50c0e3833fa2db40716f3da9
https://pubmed.ncbi.nlm.nih.gov/8114907

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Comparison of lesion size between preoperative imaging and postoperative histopathology in unifocal breast cancer

Autor: M. A. Hena, K. Hena, B. Whiteside, D. Jones, L. MacFarlan, J. Pollard, C. R. Abraham, M. Schuster

Publikováno v: Journal of Clinical Oncology. 29:1087-1087

1087 Background: Patients with biopsy-proven Stage I and Stage II breast cancer usually undergo pre-operative magnetic resonance imaging (MRI) and/or ultrasound to delineate the margins of the lesi...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06a2a7cf737fa52a9f28046638a17281
https://doi.org/10.1200/jco.2011.29.15_suppl.1087

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Facile and sensitive assay for monitoring proteolytic activities with defined specificities: studies on amyloid beta-protein processing in Alzheimer's disease

Autor: C R, Abraham, A, Bem Meir, P, Tempst

Publikováno v: Peptide research. 3(5)

A novel approach was taken to screen for the presence of highly specific proteases in tissue extracts and to monitor their purification. We successfully used this method to identify proteolytic activity in brain which may be responsible for the gener

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::72881368a33e7c0ef7715d8df94e6658
https://pubmed.ncbi.nlm.nih.gov/2134064

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