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Akademický článek

Review of quantitative and functional lung imaging evidence of vaping-related lung injury

Autor: Joseph J. Hofmann, Victoria C. Poulos, Jiahai Zhou, Maksym Sharma, Grace Parraga, Marrissa J. McIntosh

Publikováno v: Frontiers in Medicine, Vol 11 (2024)

IntroductionThe pulmonary effects of e-cigarette use (or vaping) became a healthcare concern in 2019, following the rapid increase of e-cigarette-related or vaping-associated lung injury (EVALI) in young people, which resulted in the critical care ad

Externí odkaz: https://doaj.org/article/59775f08d17946c9bdfe2d30703a2087

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Akademický článek

Regulation of macrophage apolipoprotein E gene expression by cholesterol.

Autor: T Mazzone, K Basheeruddin, C Poulos

Publikováno v: Journal of Lipid Research, Vol 30, Iss 7, Pp 1055-1064 (1989)

The relationship between macrophage cholesterol content and apolipoprotein E (apoE) gene expression was investigated in cultured mouse peritoneal macrophages. Acetylated low density lipoprotein (ALDL) at 25 micrograms/ml led to increased macrophage m

Externí odkaz: https://doaj.org/article/7e089feadc5f49419a454902f5013948

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Akademický článek

Strategies to enable large-scale proteomics for reproducible research

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

Clinical proteomics critically depends on the ability to acquire highly reproducible data over an extended period of time. Here, the authors assess reproducibility over four months across different mass spectrometers and develop a computational appro

Externí odkaz: https://doaj.org/article/f31d48fe5cbd4e4fb32261099a109959

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Akademický článek

Machine learning for multi-omics data integration in cancer

Autor: Zhaoxiang Cai, Rebecca C. Poulos, Jia Liu, Qing Zhong

Publikováno v: iScience, Vol 25, Iss 2, Pp 103798- (2022)

Summary: Multi-omics data analysis is an important aspect of cancer molecular biology studies and has led to ground-breaking discoveries. Many efforts have been made to develop machine learning methods that automatically integrate omics data. Here, w

Externí odkaz: https://doaj.org/article/b80fc226f7b941609ddc2efacedf2b9c

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Akademický článek

JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

Although the gain in chromosome 17q21-ter is commonly associated with neuroblastoma, it is not clear which gene of this region mediates tumorigenesis. Here, the authors are showing that JMJD6, which locates in that region, is a neuroblastoma tumorige

Externí odkaz: https://doaj.org/article/a673d07528164588b51a22500785ed47

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Akademický článek

Reduced nuclear DNA methylation and mitochondrial transcript changes in adenomas do not associate with mtDNA methylation

Autor: M. J. Morris, L. B. Hesson, R. C. Poulos, R. L. Ward, J. W. H. Wong, N. A. Youngson

Publikováno v: Biomarker Research, Vol 6, Iss 1, Pp 1-8 (2018)

Abstract Background Altered mitochondrial function and large-scale changes to DNA methylation patterns in the nuclear genome are both hallmarks of colorectal cancer (CRC). Mitochondria have multiple copies of a 16 kb circular genome that contains gen

Externí odkaz: https://doaj.org/article/a868f2fe58274b16a287f647070c4722

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