Zobrazeno 1 - 10
of 119
pro vyhledávání: '"C Pericleous"'
Autor:
C. Peghaire, N. P. Dufton, M. Lang, I. I. Salles-Crawley, J. Ahnström, V. Kalna, C. Raimondi, C. Pericleous, L. Inuabasi, R. Kiseleva, V. R. Muzykantov, J. C. Mason, G. M. Birdsey, A. M. Randi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
The endothelium actively maintains an anticoagulant surface through expression of thrombomodulin. Here, Peghaire et al. identify an anti-thrombotic pathway that controls thrombomodulin expression selectively in regions of low shear stress, via cooper
Externí odkaz:
https://doaj.org/article/7798914f5f094e87a7d8b776f5a7230c
Autor:
A Hartley, M Greene, M Caga-Anan, S Owen, M Mullin, C Pericleous, C Scott, J Mason, D O Haskard, R Khamis
Publikováno v:
European Heart Journal. 43
Introduction Oxidative modification of low-density lipoprotein (LDL), for example by malondialdehyde (MDA) adduction with subsequent uptake by macrophages to form foam cells and later the plaque necrotic core, is a key initiating event in atherogenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83cf2c87178ab38572478ba7f888bb5d
https://doi.org/10.1093/eurheartj/ehac544.3040
https://doi.org/10.1093/eurheartj/ehac544.3040
Akademický článek
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Publikováno v:
Atherosclerosis. 331:e291-e292
BACKGROUND Cardiovascular disease (CVD) is the primary cause of mortality worldwide. Ischemic events associated with CVD are causatively related to vascular inflammation and atherothrombosis. Certain omega-3 fatty acids, such as eicosapentaenoic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708d2eb0fd9f7ffd9e02f6545dd4bf56
https://doi.org/10.1016/j.atherosclerosis.2021.06.898
https://doi.org/10.1016/j.atherosclerosis.2021.06.898
Autor:
C Pericleous, Maura Griffin, Anisur Rahman, Filipa Farinha, Thomas McDonnell, Andrew N. Nicolaides, Ian Giles, Sara Croca
Publikováno v:
Rheumatology. 59
Background Cardiovascular disease is a significant burden on SLE patients, and no satisfactory markers exist to predict atherosclerotic development in patients. This study utilised an orthogonal approach to develop a marker of cardiovascular progress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71f26b6f1756eb9342588c4a490376dd
https://doi.org/10.1093/rheumatology/keaa111.167
https://doi.org/10.1093/rheumatology/keaa111.167
P31 Anti-domain I positivity in SLE at diagnosis is predictive of atherosclerotic plaque development
Autor:
Sara Croca, C Pericleous, Filipa Farinha, Maura Griffin, Anisur Rahman, Thomas McDonnell, Andrew Nicholaides, Ian Giles
Publikováno v:
Poster presentations.
Background Cardiovascular disease is a significant burden on SLE patients and no satisfactory markers exist to predict atherosclerotic development in patients. This study utilised an orthogonal approach to develop a marker of cardiovascular progressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8511c37f3c7ca40e5ae49f25d288e6fd
https://doi.org/10.1136/lupus-2020-eurolupus.79
https://doi.org/10.1136/lupus-2020-eurolupus.79
Publikováno v:
Abstracts Accepted for Publication.
Background: Anti-inflammatory therapy has been recently validated as a treatment option for patients with cardiovascular disease (CVD) [1]. The anti-inflammatory drug methotrexate (MTX) reduces cardiovascular risk in patients with systemic inflammato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b1e1a44561524801521e7dfbd3b71e3
https://doi.org/10.1136/annrheumdis-2019-eular.4891
https://doi.org/10.1136/annrheumdis-2019-eular.4891
Autor:
Claire Peghaire, Neil Dufton, Graeme M. Birdsey, Anna M. Randi, Josefin Ahnström, Martin Lang, Viktoria Kalna, Raisa Yu Kiseleva, L. Inuabasi, C. Pericleous, Claudio Raimondi, Isabelle I. Salles-Crawley, Justin C Mason, Vladimir R. Muzykantov
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Endothelial cells actively maintain an anti-thrombotic environment; loss of this protective function may lead to thrombosis and systemic coagulopathy. The transcription factor ERG is essential to maintain endothelial homeostasis. Here, we show that i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc45873758c331c5a2b0b1f59648b448
https://pubmed.ncbi.nlm.nih.gov/31676784
https://pubmed.ncbi.nlm.nih.gov/31676784
Autor:
Ian Giles, Ashley M. Groves, Akif A. Khawaja, Helen Booth, Dlw Chong, J. Sahota, Margaret Ashcroft, Vera M. Ripoll, C Pericleous, LW Thomas, Joanna C. Porter, G Azzopardi
Publikováno v:
Mechanistic insights into interstitial lung disease.
Background Neutrophilic inflammation is common in various diseases and may contribute to the pathophysiology of interstitial lung disease (ILD), however the underlying mechanism are not fully understood. Localised tissue hypoxia is often accompanied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32887dc6760776911fa13885f81299ee
https://doi.org/10.1136/thoraxjnl-2017-210983.85
https://doi.org/10.1136/thoraxjnl-2017-210983.85
Akademický článek
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