Výsledky vyhledávání - "C P, Schnipper"

The functional synergy between IL-12 and IL-2 involves p38 mitogen-activated protein kinase and is associated with the augmentation of STAT serine phosphorylation

Autor: J A, Gollob, C P, Schnipper, E A, Murphy, J, Ritz, D A, Frank

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 162(8)

IL-12 and IL-2 can stimulate mitogen- or CD3-activated T cells to proliferate, produce IFN-gamma, and kill tumor cells. The magnitude of these functional responses is greatly augmented when T cells are activated by the combination of IL-12 and IL-2.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::874db992ba848fec751c708212fbb431
https://pubmed.ncbi.nlm.nih.gov/10201984

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Altered interleukin-12 responsiveness in Th1 and Th2 cells is associated with the differential activation of STAT5 and STAT1

Autor: J A, Gollob, E A, Murphy, S, Mahajan, C P, Schnipper, J, Ritz, D A, Frank

Publikováno v: Blood. 91(4)

T-cell activation in response to interleukin-12 (IL-12) is mediated through signaling events that include the tyrosine phosphorylation of STAT4. IL-12 responsiveness and the ability of IL-12 to activate STAT4 is different in T cells induced to differ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3bb7242774018e8094e40864ef11befc
https://pubmed.ncbi.nlm.nih.gov/9454765

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