Výsledky vyhledávání - "C P, Ronteltap"

Clustered CD3/TCR complexes do not transduce activation signals after bispecific monoclonal antibody-triggered lysis by cytotoxic T lymphocytes via CD3

Autor: C J Blank-Voorthuis, E Braakman, C P Ronteltap, B C Tilly, E Sturm, S O Warnaar, R L Bolhuis

Publikováno v: The Journal of Immunology. 151:2904-2914

Bispecfic mAb (bsmAb) directed against the CD3/TCR complex and a tumor-associated Ag (TAA) induces CTL-mediated lysis of TAA+ target cells. We have investigated whether bsmAb-pretargeted CTL can enter multiple lytic cycles. BsmAb-pretargeted CTL reta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da4a7fc6feb40f79562c22fd8527fd1e
https://doi.org/10.4049/jimmunol.151.6.2904

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Clustered CD3/TCR complexes do not transduce activation signals after bispecific monoclonal antibody-triggered lysis by cytotoxic T lymphocytes via CD3

Autor: C J, Blank-Voorthuis, E, Braakman, C P, Ronteltap, B C, Tilly, E, Sturm, S O, Warnaar, R L, Bolhuis

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 151(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cbfc09ed3c1294d82ed8f756e8b1ad21
https://pubmed.ncbi.nlm.nih.gov/8376761

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Rapidly expanded activated human killer cell clones have strong antitumor cell activity and have the surface phenotype of either T gamma, T-non-gamma, or null cells

Autor: R J van de Griend, B A van Krimpen, C P Ronteltap, R L Bolhuis

Publikováno v: The Journal of Immunology. 132:3185-3191

Cloned lymphoid cell lines showing cytolytic activity were derived from natural killer (NK) cell-enriched cell fractions obtained by fluorescence-activated cell sorting of cells that reacted with B73 .1, an NK cell-specific monoclonal antibody (MCA).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01290920a7f996b4378be1dfc70143d5
https://doi.org/10.4049/jimmunol.132.6.3185

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Lysis of tumor cells by CD3+4-8-16+ T cell receptor alpha beta- clones, regulated via CD3 and CD16 activation sites, recombinant interleukin 2, and interferon beta 1

Autor: R J van de Griend, W J Tax, B A van Krimpen, R J Vreugdenhil, C P Ronteltap, R L Bolhuis

Publikováno v: The Journal of Immunology. 138:1627-1633

A small subpopulation (about 2%) of normal CD3+ human T lymphocytes lacks both CD4 and CD8 antigens. We have cloned these cells from peripheral blood lymphocytes (PBL) obtained from healthy individuals and from a patient with severe combined immunode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8a317296c13a1dfee48fc7a49019253
https://doi.org/10.4049/jimmunol.138.5.1627

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Interferon-beta and recombinant IL 2 can both enhance, but by different pathways, the nonspecific cytolytic potential of T3- natural killer cell-derived clones rather than that of T3+ clones

Autor: R J van de Griend, C P Ronteltap, C Gravekamp, D Monnikendam, R L Bolhuis

Publikováno v: The Journal of Immunology. 136:1700-1707

We studied the enhancement of cytolytic activity of T3- natural killer cell-derived clones, of T3+ T cell activated killer (AK) clones, and of fresh peripheral blood lymphocytes (PBL) by various crude and recombinant interferon (r-IFN) as well as IL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e4fcc8f599cc474d09dfabf39b35c0d
https://doi.org/10.4049/jimmunol.136.5.1700

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Clonal expansion of human B73.1-positive natural killer cells or large granular lymphocytes exerting strong antibody-dependent and -independent cytotoxicity and occasionally lectin-dependent cytotoxicity

Autor: R L, Bolhuis, R J, van de Griend, C P, Ronteltap

Publikováno v: Natural immunity and cell growth regulation. 3(2)

B73.1-positive natural killer (NK) cells were separated from B73.1- cells by fluorescent-activated cell sorting and used for the generation of cytotoxic clones. The B73.1+ and B73.1- cells were cultured at one responder cell per well in medium with f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0b25d7449c7081cac7f7e6a433ec5dc7
https://pubmed.ncbi.nlm.nih.gov/6679886

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Cellular cytotoxicity assessed by the 51Cr release assay. Biological interpretation of mathematical parameters

Autor: S J, Bol, H J, Rosdorff, C P, Ronteltap, L A, Hennen

Publikováno v: Journal of immunological methods. 90(1)

This study deals with the interpretation of primary data of the 51Cr release assay for cellular cytotoxicity. In particular the dose-effect relationship between increasing numbers of lymphoid cells and the percentage of target cells killed has been c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f59c59782913149e8e6bdc550a91d657
https://pubmed.ncbi.nlm.nih.gov/3486921

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