Zobrazeno 1 - 10
of 151
pro vyhledávání: '"C Oseroff"'
Autor:
G Y, Ishioka, J, Fikes, G, Hermanson, B, Livingston, C, Crimi, M, Qin, M F, del Guercio, C, Oseroff, C, Dahlberg, J, Alexander, R W, Chesnut, A, Sette
Publikováno v:
The Journal of Immunology. 162:3915-3925
We engineered a multiepitope DNA minigene encoding nine dominant HLA-A2.1- and A11-restricted epitopes from the polymerase, envelope, and core proteins of hepatitis B virus and HIV, together with the PADRE (pan-DR epitope) universal Th cell epitope a
Autor:
J Alexander, C Oseroff, J Sidney, P Wentworth, E Keogh, G Hermanson, F V Chisari, R T Kubo, H M Grey, A Sette
Publikováno v:
The Journal of Immunology. 159:4753-4761
Transgenic mice expressing chimeric human (alpha1 and alpha2 HLA-A11 domains) and murine (alpha3, transmembrane, and cytoplasmic H-2Kb domains) class I molecules were derived. These mice were used as a model system to study the immunogenicity of huma
Autor:
Rafi Ahmed, S Southwood, J Sidney, J Alexander, R. J. Concepcion, R W Chesnut, R G van der Most, Alessandro Sette, C Oseroff
Publikováno v:
Journal of Virology. 71:5110-5114
The cytotoxic T-lymphocyte response against lymphocytic choriomeningitis virus (LCMV) in BALB/c mice is predominantly directed against a single, Ld-restricted epitope in the viral nucleoprotein (residues 118 to 126). To investigate whether any Kd/Dd-
Autor:
R G van der Most, A Sette, C Oseroff, J Alexander, K Murali-Krishna, L L Lau, S Southwood, J Sidney, R W Chesnut, M Matloubian, R Ahmed
Publikováno v:
The Journal of Immunology. 157:5543-5554
The cytotoxic T cell response against lymphocytic choriomeningitis virus (LCMV) in BALB/c (H-2d) mice is predominantly directed against a single immunodominant Ld-restricted epitope in the viral nucleoprotein (NP118-126). Here we report that the immu
Autor:
M E Ressing, A Sette, R M Brandt, J Ruppert, P A Wentworth, M Hartman, C Oseroff, H M Grey, C J Melief, W M Kast
Publikováno v:
The Journal of Immunology. 154:5934-5943
Human papillomavirus type 16 (HPV16) is strongly associated with cervical carcinogenesis. The HPV16 E6 and E7 oncoproteins are constitutively expressed in the majority of cervical tumor cells and are, therefore, attractive targets for CTL-mediated im
Autor:
A Geluk, K E van Meijgaarden, S Southwood, C Oseroff, J W Drijfhout, R R de Vries, T H Ottenhoff, A Sette
Publikováno v:
The Journal of Immunology. 152:5742-5748
Three different HLA-DR3-specific peptide binding motifs have been proposed. These motifs shared a major hydrophobic anchor at the N-terminus, but differed in the C-terminal anchor residues. In the present study, the structural requirements for peptid
Autor:
J Sidney, C Oseroff, M F del Guercio, S Southwood, J I Krieger, G Y Ishioka, K Sakaguchi, E Appella, A Sette
Publikováno v:
The Journal of Immunology. 152:4516-4525
A quantitative peptide binding assay using purified DQA1*0301/DQB1*0301 (DQ3.1) molecules was developed and validated by examining the correlation between the data obtained in the binding assay with those obtained in inhibition of Ag presentation ass
Autor:
Kai W. Wucherpfennig, M. Matsui, David A. Hafler, A Sette, Scott Southwood, Jack L. Strominger, C Oseroff
Publikováno v:
The Journal of Experimental Medicine
Immunodominant T cell epitopes of myelin basic protein (MBP) may be target antigens for major histocompatibility complex class II-restricted, autoreactive T cells in multiple sclerosis (MS). Since susceptibility to MS is associated with the DR2 haplo
Autor:
A Sette, J Sidney, C Oseroff, M F del Guercio, S Southwood, T Arrhenius, M F Powell, S M Colón, F C Gaeta, H M Grey
Publikováno v:
The Journal of Immunology. 151:3163-3170
In the present study, we describe the definition of a DRB1*0401 (DR4w4)-specific motif. The strategy used entailed a three-step process: 1) screening a large set of unrelated peptide ligands to identify good MHC binders; 2) truncation analysis of sev
Autor:
J Alexander, K Snoke, J Ruppert, J Sidney, M Wall, S Southwood, C Oseroff, T Arrhenius, F C Gaeta, S M Colón
Publikováno v:
The Journal of Immunology. 150:1-7
The mechanisms involved in TCR antagonism by Ag analog/MHC have been analyzed. A detailed structure-activity relationship study indicated that modification of any of the major T cell contact residues of the peptide molecule can yield a powerful antag