Zobrazeno 1 - 10
of 50
pro vyhledávání: '"C Nkhoma"'
Autor:
John Kane, Xue Li, Sudhir Kumar, Katrina A. Button-Simons, Katelyn M. Vendrely Brenneman, Haley Dahlhoff, Mackenzie A. C. Sievert, Lisa A. Checkley, Douglas A. Shoue, Puspendra P. Singh, Biley A. Abatiyow, Meseret T. Haile, Shalini Nair, Ann Reyes, Rupam Tripura, Thomas J. Peto, Dysoley Lek, Angana Mukherjee, Stefan H. I. Kappe, Mehul Dhorda, Standwell C. Nkhoma, Ian H. Cheeseman, Ashley M. Vaughan, Timothy J. C. Anderson, Michael T. Ferdig
Publikováno v:
mBio, Vol 15, Iss 7 (2024)
ABSTRACT Piperaquine (PPQ) is widely used in combination with dihydroartemisinin as a first-line treatment against malaria. Multiple genetic drivers of PPQ resistance have been reported, including mutations in the Plasmodium falciparum chloroquine re
Externí odkaz:
https://doaj.org/article/b191e5641f084dea867745f9b4a6c1b8
Autor:
Standwell C. Nkhoma, Amel O.A. Ahmed, Sharmeen Zaman, Danielle Porier, Zachary Baker, Timothy T. Stedman
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 15, Iss , Pp 152-161 (2021)
Natural infections of Plasmodium falciparum, the parasite responsible for the deadliest form of human malaria, often comprise multiple parasite lineages (haplotypes). Multiclonal parasite isolates may exhibit variable phenotypes including different d
Externí odkaz:
https://doaj.org/article/3e6bcbff6d9444188b5dd591cda63c99
Autor:
Katelyn Vendrely Brenneman, Xue Li, Sudhir Kumar, Elizabeth Delgado, Lisa A. Checkley, Douglas A. Shoue, Ann Reyes, Biley A. Abatiyow, Meseret T. Haile, Rupam Tripura, Tom Peto, Dysoley Lek, Katrina A. Button-Simons, Stefan H.I. Kappe, Mehul Dhorda, François Nosten, Standwell C. Nkhoma, Ian H. Cheeseman, Ashley M. Vaughan, Michael T. Ferdig, Tim J.C. Anderson
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104095- (2022)
Summary: Classical malaria parasite genetic crosses involve isolation, genotyping, and phenotyping of progeny parasites, which is time consuming and laborious. We tested a rapid alternative approach—bulk segregant analysis (BSA)—that utilizes seq
Externí odkaz:
https://doaj.org/article/92955e99b1f54ae581be8c1979028447
Autor:
B Dey, B Visser, HQ Tin, A Mahamadou Laouali, N Baba Toure Mahamadou, C Nkhoma, S Alonzo Recinos, C Opiyo, S Bragdon
Publikováno v:
Outlook on Agriculture. 51:359-371
In many countries, smallholder farmers play a key role in food crop seed production. So far, the community roles, operational structures, seed production efficiency, aspects of sustainability, and the social and policy environments in which these gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28ed2eb94b7f725df064b431d557ba2b
https://doi.org/10.1177/00307270221115454
https://doi.org/10.1177/00307270221115454
Autor:
Aimee R Taylor, Stephen F Schaffner, Gustavo C Cerqueira, Standwell C Nkhoma, Timothy J C Anderson, Kanlaya Sriprawat, Aung Pyae Phyo, François Nosten, Daniel E Neafsey, Caroline O Buckee
Publikováno v:
PLoS Genetics, Vol 13, Iss 10, p e1007065 (2017)
With the rapidly increasing abundance and accessibility of genomic data, there is a growing interest in using population genetic approaches to characterize fine-scale dispersal of organisms, providing insight into biological processes across a broad
Externí odkaz:
https://doaj.org/article/e25b1bd5e1f24caa94c32d02d468b39d
Autor:
Sharmeen Zaman, Timothy T. Stedman, Amel O.A. Ahmed, Danielle Porier, Standwell C. Nkhoma, Zachary Baker
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 15, Iss, Pp 152-161 (2021)
International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance
Natural infections of Plasmodium falciparum, the parasite responsible for the deadliest form of human malaria, often comprise multiple parasite lineages (haplotypes). Multiclonal parasite isolates may exhibit variable phenotypes including different d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f90febb2789f2f53d263b20b918843f8
https://doi.org/10.1016/j.ijpddr.2021.03.001
https://doi.org/10.1016/j.ijpddr.2021.03.001
Autor:
Standwell C. Nkhoma, Amel O.A. Ahmed, Danielle Porier, Sujatha Rashid, Rebecca Bradford, Robert E. Molestina, Timothy T. Stedman
Publikováno v:
Molecular and Biochemical Parasitology. 254:111552
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a5233ee422eaa0913ee05b22ab9cf81
https://doi.org/10.1016/j.molbiopara.2023.111552
https://doi.org/10.1016/j.molbiopara.2023.111552
Publikováno v:
J Infect Dis
Background Rapid diagnostic tests based on detection of histidine-rich proteins (HRPs) are widely used for malaria diagnosis, but parasites carrying pfhrp deletions can evade detection and are increasing in frequency in some countries. Models aim to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed8659512a5dfc28d10b1fa437973fd
https://pubmed.ncbi.nlm.nih.gov/35709327
https://pubmed.ncbi.nlm.nih.gov/35709327
Autor:
Joseph R M, Fulakeza, Rachel L, Banda, Trancizeo R, Lipenga, Dianne J, Terlouw, Standwell C, Nkhoma, Eva Maria, Hodel
Publikováno v:
The American Journal of Tropical Medicine and Hygiene
Genotyping of allelic variants of Plasmodium falciparum merozoite surface proteins 1 and 2 (msp-1 and msp-2), and the glutamate-rich protein is the gold standard for distinguishing reinfections from recrudescences in antimalarial drug trials. We comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::345ce72a32bc46b15aa28c46afb3f3cd
https://pubmed.ncbi.nlm.nih.gov/29785925
https://pubmed.ncbi.nlm.nih.gov/29785925
Autor:
Standwell C, Nkhoma, Rachel L, Banda, Stanley, Khoswe, Tamika J, Dzoole-Mwale, Stephen A, Ward
Publikováno v:
Infection, Genetics and Evolution
Malaria-infected individuals often harbor mixtures of genetically distinct parasite genotypes. We studied intra-host dynamics of parasite genotypes co-infecting asymptomatic adults in an area of intense malaria transmission in Chikhwawa, Malawi. Seri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d0499b4abfb391f583b1da967010dfbb
https://pubmed.ncbi.nlm.nih.gov/30145390
https://pubmed.ncbi.nlm.nih.gov/30145390