Zobrazeno 1 - 10
of 30
pro vyhledávání: '"C N, Falany"'
Publikováno v:
Journal of Lipid Research, Vol 38, Iss 6, Pp 1139-1148 (1997)
A mouse liver lambda Zap XR cDNA library was screened using the coding region of human bile acid CoA:amino acid N-acyltransferase (BAT) cDNA as a probe. Ten positive clones were isolated and purified, two of which apparently possessed complete open r
Externí odkaz:
https://doaj.org/article/1c448cbe44a5469098637474ea819230
Publikováno v:
Journal of Biological Chemistry. 273:10888-10892
Estrogen sulfotransferase (EST) catalyzes the transfer of the sulfuryl group from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to 17beta-estradiol (E2). The sulfation of E2 prevents it from binding to, and thereby activating, the estrogen receptor. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cff28d657eade3f61cea1a0bbd7db76
https://doi.org/10.1074/jbc.273.18.10888
https://doi.org/10.1074/jbc.273.18.10888
Publikováno v:
Diabetes. 40:1360-1363
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33c7de112b50a3ccd41699a5b3bca4ae
https://doi.org/10.2337/diabetes.40.10.1360
https://doi.org/10.2337/diabetes.40.10.1360
Publikováno v:
The Biochemical journal. 356(Pt 3)
Sulphation is an important conjugation pathway in drug metabolism that has been studied in several species including humans. However, few studies have been performed using the dog as a subject. In this report we describe the cloning and characterizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::650e404c2a3240f58a27a30070c7ce5d
https://pubmed.ncbi.nlm.nih.gov/11389699
https://pubmed.ncbi.nlm.nih.gov/11389699
Autor:
C Wooldridge, Guangping Chen, D Zhang, J L York, C N Falany, Anna Radominska-Pandya, P A Rabjohn
Publikováno v:
Biochemistry. 39(51)
The carboxyl-specific amino acid modification reagent, Woodward's reagent K (WK), was utilized to characterize carboxyl residues (Asp and Glu) in the active site of human phenol sulfotransferase (SULT1A1). SULT1A1 was purified using the pMAL-c2 expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6157f03002ca91ba698381cb108647ae
https://pubmed.ncbi.nlm.nih.gov/11123927
https://pubmed.ncbi.nlm.nih.gov/11123927
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(9)
The metabolism of the local anesthetics lidocaine and ropivacaine (ropi) involves several steps in humans. Lidocaine is mainly hydrolyzed and hydroxylated to 4-OH-2,6-xylidine (4-OH-xyl). The metabolism of ropi, involving dealkylation and hydroxylati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eba8c58e89b73d6d37706efc4266e47c
https://pubmed.ncbi.nlm.nih.gov/10460806
https://pubmed.ncbi.nlm.nih.gov/10460806
Publikováno v:
Carcinogenesis. 19(11)
Cooked food mutagens from fried meat and fish have recently been suggested to contribute to the etiology of breast cancer. Thus, the most prevalent of these compounds, i.e. 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, or rather its more mutagenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8378b148f7e71dc119df1f8878137f49
https://pubmed.ncbi.nlm.nih.gov/9855023
https://pubmed.ncbi.nlm.nih.gov/9855023
Publikováno v:
Chirality. 10(9)
The beta 2-receptor agonist class of drugs is metabolized in humans almost exclusively by sulfate conjugation. The objective of this investigation was to determine the influence of chemical structure on the stereoselectivity of the sulfoconjugation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0ced7a05ded1188f2b070ce6b29fd583
https://pubmed.ncbi.nlm.nih.gov/9839429
https://pubmed.ncbi.nlm.nih.gov/9839429
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 26(8)
Xenobiotics that induce the cytochromes P450 also produce changes in rat hepatic sulfotransferase (SULT) gene expression. In the present study, male Sprague-Dawley rats were treated for 3 consecutive days with doses of phenobarbital (PB) that induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::953d53bd8d63db7553c50d0639078220
https://pubmed.ncbi.nlm.nih.gov/9698295
https://pubmed.ncbi.nlm.nih.gov/9698295
Autor:
J L, Falany, C N, Falany
Publikováno v:
Oncology research. 9(11-12)
Estrogen metabolism is closely associated with the growth, progression, and treatment of breast cancer because many breast cancers are dependent upon estrogens for both growth and progression. Factors that affect the intracellular metabolism of estro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a2a3cfdbb6258673aaefbceaa0a79379
https://pubmed.ncbi.nlm.nih.gov/9563006
https://pubmed.ncbi.nlm.nih.gov/9563006