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PO.6.127 Efavaleukin alfa, a novel IL-2 mutein, selectively expands regulatory t cells in patients with SLE: final results of a phase 1b multiple ascending dose study

Autor: R Zhang, C Stanley, X Hu, V Chow, N Tchao, R Furie, N Sarkar, C Milmont, Y Shi Jin, M Kroenke, K Gorski, K Alan

Publikováno v: Lupus Science and Medicine, Vol 9, Iss Suppl 2 (2022)

Externí odkaz: https://doaj.org/article/1e951f1a62ee4efb81121fa2000db0f1

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PO.6.127 Efavaleukin alfa, a novel IL-2 mutein, selectively expands regulatory t cells in patients with SLE: final results of a phase 1b multiple ascending dose study

Autor: N Tchao, N Sarkar, X Hu, R Zhang, C Milmont, Y Shi Jin, V Chow, M Kroenke, K Gorski, R Furie, K Alan, C Stanley

Publikováno v: Friday 07 October 2022 from 13:00 to 14:10.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a3bc752395833054f729ac08bf458ee
https://doi.org/10.1136/lupus-2022-elm2022.148

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AB0432 EFAVALEUKIN ALFA, A NOVEL IL-2 MUTEIN, SELECTIVELY EXPANDS REGULATORY T CELLS IN PATIENTS WITH SLE: FINAL RESULTS OF A PHASE 1B MULTIPLE ASCENDING DOSE STUDY

Autor: N. Tchao, N. Sarkar, X. Hu, R. Zhang, C. Milmont, Y. Shi Jin, V. Chow, M. Kroenke, K. Gorski, R. Furie, A. Kivitz, S. Cohen

Publikováno v: Annals of the Rheumatic Diseases. 81:1343.3-1344

BackgroundDefects in regulatory T cell (Treg) number and function are associated with autoimmune diseases including SLE. Interleukin (IL)-2 is essential for the development and suppressive function of Treg, and therapies that exploit the ability of I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::677fe47daa49dfb7cc9ab69decf6b824
https://doi.org/10.1136/annrheumdis-2022-eular.2244

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