Zobrazeno 1 - 10
of 77
pro vyhledávání: '"C Michael Knudson"'
Autor:
Arya Sobhakumari, Laurie Love-Homan, Elise V M Fletcher, Sean M Martin, Arlene D Parsons, Douglas R Spitz, C Michael Knudson, Andrean L Simons
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e48175 (2012)
Increased glutathione (GSH) and thioredoxin (Trx) metabolism are mechanisms that are widely implicated in resistance of cancer cells to chemotherapy. The current study determined if simultaneous inhibition of GSH and Trx metabolism enhanced cell kill
Externí odkaz:
https://doaj.org/article/9c3f6038b8924659b32b069d7c274fdd
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19786 (2011)
Caspase-9 is a component of the apoptosome that mediates cell death following release of cytochrome c from mitochondria. Inhibition of Caspase-9 with a dominant negative construct (Casp9DN) blocks apoptosome function, promotes viability and has been
Externí odkaz:
https://doaj.org/article/19aa03f2034443c1be299cf58981fbaa
Publikováno v:
PLoS ONE, Vol 3, Iss 4, p e1911 (2008)
The effect of Bcl-2 on oncogenesis is complex and expression may either delay or accelerate oncogenesis. The pro-oncogenic activity is attributed to its well characterized anti-apoptotic function while the anti-oncogenic function has been attributed
Externí odkaz:
https://doaj.org/article/d623c4cfdfc74675b056ff74c7f61729
Autor:
Hanora A. Van Ert, Dana W. Bohan, Kai Rogers, Mohammad Fili, Roberth A. Rojas Chávez, Enya Qing, Changze Han, Spencer Dempewolf, Guiping Hu, Nathan Schwery, Kristina Sevcik, Natalie Ruggio, Devlin Boyt, Michael A. Pentella, Tom Gallagher, J. Brooks Jackson, Anna E. Merrill, C. Michael Knudson, Grant D. Brown, Wendy Maury, Hillel Haim
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 1 (2022)
ABSTRACT The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is arranged as a trimer on the virus surface, composed of three S1 and three S2 subunits. Infected and vaccinated individuals generate antibodies against spike
Externí odkaz:
https://doaj.org/article/d91f201a1a454c09a2b3fe510f6ca70b
Autor:
Ryan Kolb, Liem Phan, Nicholas Borcherding, Yinghong Liu, Fang Yuan, Ann M. Janowski, Qing Xie, Kathleen R. Markan, Wei Li, Matthew J. Potthoff, Enrique Fuentes-Mattei, Lesley G. Ellies, C. Michael Knudson, Mong-Hong Lee, Sai-Ching J. Yeung, Suzanne L. Cassel, Fayyaz S. Sutterwala, Weizhou Zhang
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Obesity is associated with higher breast cancer risk and poor prognosis. Here, the authors show that obesity promotes breast cancer through the recruitment of macrophages with activated NLRC4 inflammasome, which activate IL-1β production, resulting
Externí odkaz:
https://doaj.org/article/8dc39d9da6c541818c16001eb4cc7191
Publikováno v:
Transfusion. 62(12)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9f3f64b5975f4a766b9c5e0fb3c643b
https://pubmed.ncbi.nlm.nih.gov/36478384
https://pubmed.ncbi.nlm.nih.gov/36478384
Autor:
Anna E. Merrill, Abby E. Odle, Myrl Holida, Kerry A. Dubay, C. Michael Knudson, Judith Leon, Aaron V. Locher, Molly A. Vickers, Laura Collins, Stanley Perlman, Alexandra Ehlers, Alan Sariol, Dena R. Voss
Publikováno v:
Transfusion
Background With the recent approval of COVID‐19 vaccines, recovered COVID‐19 subjects who are vaccinated may be ideal candidates to donate COVID‐19 convalescent plasma (CCP). Case Series Eleven recovered COVID‐19 patients were screened to don
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e579ad2b047fcf45efc1471365532c6
https://doi.org/10.1111/trf.16401
https://doi.org/10.1111/trf.16401
Publikováno v:
TransfusionREFERENCES. 62(9)
A direct antiglobulin test (DAT) checks for antibody or complement on the surface of RBCs and is often done following a transfusion reaction. While passive anti-A and anti-B antibodies are known to cause positive DATs, the extent this occurs followin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94f4cf16328466d4392404181c09974f
https://pubmed.ncbi.nlm.nih.gov/35836408
https://pubmed.ncbi.nlm.nih.gov/35836408
Autor:
Abhishek Kumar Verma, Stanley Perlman, Paul B. McCray, David K. Meyerholz, Jian Zheng, C. Michael Knudson, M. Ortiz, Mariah R. Leidinger, Christine L. Wohlford-Lenane, Lok-Yin Roy Wong, Kun Li
Publikováno v:
Nature. 589:603-607
The ongoing coronavirus disease 2019 (COVID-19) pandemic is associated with substantial morbidity and mortality. Although much has been learned in the first few months of the pandemic, many features of COVID-19 pathogenesis remain to be determined. F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61d37afea85f9f3146bd9b75c95c94cd
https://doi.org/10.1038/s41586-020-2943-z
https://doi.org/10.1038/s41586-020-2943-z
Autor:
Changze Han, Michael Pentella, Mohammad Fili, Natalie Ruggio, Guiping Hu, Grant D. Brown, J. Brooks Jackson, Kristina M. Sevcik, Kai J. Rogers, Tom Gallagher, Wendy Maury, Hanora A Van Ert, Nathan Schwery, C. Michael Knudson, Spencer Dempewolf, Anthony Roberth Rojas Chavez, Anna E. Merrill, Devlin Boyt, Dana Bohan, Enya Qing, Hillel Haim
Publikováno v:
Microbiology Spectrum. 10
The spike protein of SARS-CoV-2 is arranged as a trimer on the virus surface, composed of three S1 and three S2 subunits. Infected and vaccinated individuals generate antibodies against spike, which can neutralize the virus. Most antibodies target th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb9c2f8821dafa6d15e6899216626fd
https://doi.org/10.1128/spectrum.02676-21
https://doi.org/10.1128/spectrum.02676-21