Zobrazeno 1 - 10
of 337
pro vyhledávání: '"C Michael, Stein"'
Autor:
Jonathan D. Mosley, John P. Shelley, Alyson L. Dickson, Jacy Zanussi, Laura L. Daniel, Neil S. Zheng, Lisa Bastarache, Wei-Qi Wei, Mingjian Shi, Gail P. Jarvik, Elisabeth A. Rosenthal, Atlas Khan, Alborz Sherafati, Iftikhar J. Kullo, Theresa L. Walunas, Joseph Glessner, Hakon Hakonarson, Nancy J. Cox, Dan M. Roden, Stephan G. Frangakis, Brett Vanderwerff, C. Michael Stein, Sara L. Van Driest, Scott C. Borinstein, Xiao-Ou Shu, Matthew Zawistowski, Cecilia P. Chung, Vivian K. Kawai
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Polygenic variation unrelated to disease contributes to interindividual variation in baseline white blood cell (WBC) counts, but its clinical significance is uncharacterized. We investigated the clinical consequences of a genetic predisposit
Externí odkaz:
https://doaj.org/article/aac9cb1b2aa64c909fbdd66e307ed326
Autor:
Chao Yan, Monika E. Grabowska, Alyson L. Dickson, Bingshan Li, Zhexing Wen, Dan M. Roden, C. Michael Stein, Peter J. Embí, Josh F. Peterson, QiPing Feng, Bradley A. Malin, Wei-Qi Wei
Publikováno v:
npj Digital Medicine, Vol 7, Iss 1, Pp 1-6 (2024)
Abstract Drug repurposing represents an attractive alternative to the costly and time-consuming process of new drug development, particularly for serious, widespread conditions with limited effective treatments, such as Alzheimer’s disease (AD). Em
Externí odkaz:
https://doaj.org/article/5a14ed00b9d54394bba0dc3ee3901fe9
Autor:
Lan Jiang, Srushti Gangireddy, Alyson L. Dickson, Yi Xin, Chao Yan, Vivian Kawai, Nancy J. Cox, MacRae F. Linton, Wei-Qi Wei, C. Michael Stein, QiPing Feng
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 6, Pp 100569- (2024)
Hypertriglyceridemia (HTG) is a common cardiovascular risk factor characterized by elevated triglyceride (TG) levels. Researchers have assessed the genetic factors that influence HTG in studies focused predominantly on individuals of European ancestr
Externí odkaz:
https://doaj.org/article/da16de995003474fb80d5f0f18e3d4e6
Autor:
Joan M. Bathon, Michael Centola, Xiaoqian Liu, Zhicheng Jin, Weihua Ji, Nicholas S. Knowlton, Iván Ferraz-Amaro, Qin Fu, Jon T. Giles, Mary Chester Wasko, C. Michael Stein, Jennifer E. Van Eyk
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-12 (2023)
Abstract Background Cardiovascular (CV) risk estimation calculators for the general population underperform in patients with rheumatoid arthritis (RA). The purpose of this study was to identify relevant protein biomarkers that could be added to tradi
Externí odkaz:
https://doaj.org/article/f49305ff219a466d96de08cfc25c96e6
Autor:
Jacy T. Zanussi, Juan Zhao, Wei-Qi Wei, Gul Karakoc, Cecilia P. Chung, QiPing Feng, Nancy J. Olsen, C. Michael Stein, Vivian K. Kawai
Publikováno v:
BMC Rheumatology, Vol 7, Iss 1, Pp 1-11 (2023)
Abstract Background Antinuclear antibodies (ANA) are antibodies present in several autoimmune disorders. However, a large proportion of the general population (20%) also have a positive test; very few of these individuals will develop an autoimmune d
Externí odkaz:
https://doaj.org/article/280a134e6c6c4265ac4f1fd6e3ad3683
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Some autoimmune (AI) conditions affect white blood cell (WBC) counts. Whether a genetic predisposition to AI disease associates with WBC counts in populations expected to have low numbers of AI cases is not known. We developed genetic instru
Externí odkaz:
https://doaj.org/article/461cf0eba7224fabacf6c024ba8c466a
Autor:
Lan Jiang, Ge Liu, Annette Oeser, Andrea Ihegword, Alyson L Dickson, Laura L Daniel, Adriana M Hung, Nancy J Cox, Cecilia P Chung, Wei-Qi Wei, C Michael Stein, Qiping Feng
Publikováno v:
eLife, Vol 12 (2023)
Background: Two risk variants in the apolipoprotein L1 gene (APOL1) have been associated with increased susceptibility to sepsis in Black patients. However, it remains unclear whether APOL1 high-risk genotypes are associated with occurrence of either
Externí odkaz:
https://doaj.org/article/3baa0f4a81db461eb55066a00231d9f0
Autor:
Ge Liu, Lan Jiang, V. Eric Kerchberger, Annette Oeser, Andrea Ihegword, Alyson L. Dickson, Laura L. Daniel, Christian Shaffer, MacRae F. Linton, Nancy Cox, Cecilia P. Chung, Wei‐Qi Wei, C. Michael Stein, QiPing Feng
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 3, Pp 489-501 (2023)
Abstract Sepsis accounts for one in three hospital deaths. Higher concentrations of high‐density lipoprotein cholesterol (HDL‐C) are associated with apparent protection from sepsis, suggesting a potential therapeutic role for HDL‐C or drugs, su
Externí odkaz:
https://doaj.org/article/f1784ad21d1243438fdafdbfcfef9f94
Autor:
Lan Jiang, V. Eric Kerchberger, Christian Shaffer, Alyson L. Dickson, Michelle J. Ormseth, Laura L. Daniel, Barbara G. Carranza Leon, Nancy J. Cox, Cecilia P. Chung, Wei-Qi Wei, C. Michael Stein, QiPing Feng
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-11 (2022)
Abstract Introduction Infectious diseases are common causes of morbidity and mortality worldwide. Susceptibility to infection is highly heritable; however, little has been done to identify the genetic determinants underlying common infectious disease
Externí odkaz:
https://doaj.org/article/fbb8510073534dcdbf972a289871a537
Autor:
Laura L. Daniel, Alyson L. Dickson, Jacy T. Zanussi, Tyne W. Miller‐Fleming, Peter S. Straub, Wei‐Qi Wei, W. Dale Plummer, William D. Dupont, Ge Liu, Prathima Anandi, Tyler S. Reese, Kelly A. Birdwell, Vivian K. Kawai, Adriana M. Hung, Nancy J. Cox, QiPing Feng, C. Michael Stein, Cecilia P. Chung
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 4, Pp 859-865 (2022)
Abstract TPMT and NUDT15 variants explain less than 25% of azathioprine‐associated myelotoxicity. There are 25 additional genes in the thiopurine pathway that could also contribute to azathioprine myelotoxicity. We hypothesized that among TPMT and
Externí odkaz:
https://doaj.org/article/d9be93e9da0342d682ede0bd27615d67