Zobrazeno 1 - 10
of 40
pro vyhledávání: '"C Meichsner"'
Autor:
R Bender, K E Schneweis, A Paessens, Helga Rübsamen-Waigmann, M. Wichers, J P Kleim, Reinhard Kirsch, M Rösner, Rolf Kaiser, C Meichsner
Publikováno v:
Antimicrobial Agents and Chemotherapy. 39:2253-2257
HBY 097 [(S)-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3, 4-dihydroquinoxaline-2(1H)-thione] was selected from a series of quinoxalines as a nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (NNRTI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fef873d31e848c801075de17045e7b3
https://doi.org/10.1128/aac.39.10.2253
https://doi.org/10.1128/aac.39.10.2253
Autor:
H. von Briesen, Helga Rübsamen-Waigmann, R. Esser, Reinhard Andreesen, C. Meichsner, E. Schrinner
Publikováno v:
Research in Virology. 141:251-257
Due to the important role of monocytes/macrophages in the pathogenesis of AIDS, potential drugs with anti-HIV activity in lymphocytes must also be effective in monocytes/macrophages. For testing the efficacy of antiviral substances, monocytes/macroph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d9f765c188e5df7faefad386e0af81
https://doi.org/10.1016/0923-2516(90)90029-i
https://doi.org/10.1016/0923-2516(90)90029-i
Autor:
Ursula Dietrich, H. von Briesen, C. Meichsner, Renate Kreutz, A Seipp, Herbert Kühnel, H. Rübsamen-Waigmann, Michalina Adamski
Publikováno v:
Research in Virology. 141:233-237
HIV2 strains were isolated from a Gambian with neuro-AIDS (HIV2 D194 ) and from an asymptomatic Ghanian (HIV2 D205 ). Like HIV1 biological subtype c, both isolates grew slowly and induced few or no syncytia, but eventually produced high levels of par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d2beec4ff74db5a9afbcc7650bc3ab
https://doi.org/10.1016/0923-2516(90)90026-f
https://doi.org/10.1016/0923-2516(90)90026-f
Autor:
Anusch Peyman, Jutta Dr Hansen, K.‐H. Budt, Jörg Spanig, Irvin Winkler, D. Ruppert, J. Knolle, C. Meichsner, Arnold Dr. Paessens, Bernd Stowasser, L. Jian-Qi
Publisher Summary This chapter describes a series of inhibitors in which a central building block, containing a transition-state mimetic and the P1 and P1’ residues of the HIV-PR cleavage site, is placed in a C 2 -symmetrical peptidic environment a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6c2b2a60e7d427e044faac8f52112c2
https://doi.org/10.1016/s0165-7208(97)80081-5
https://doi.org/10.1016/s0165-7208(97)80081-5
Publikováno v:
Virology. 200(2)
S-2720 and other members of the quinoline/quinoxaline class of HIV-1-specific nonnucleoside reverse transcriptase inhibitors (NNRTIs) select for a glycine to glutamate substitution at residue 190 (Gly 190 Glu) of the reverse transcriptase (RT), when
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f171af7ea8bf68ead139a5056e5c5e46
https://pubmed.ncbi.nlm.nih.gov/7513921
https://pubmed.ncbi.nlm.nih.gov/7513921
Autor:
A Paessens, U M Billhardt, Irvin Winkler, C Meichsner, M Rösner, R Bender, J P Kleim, G Riess
Publikováno v:
Antimicrobial agents and chemotherapy. 37(8)
S-2720 [6-chloro-3,3-dimethyl-4-(isopropenyloxycarbonyl)-3,4- dihydroquinoxalin-2(1H)-thione], a quinoxaline derivative, was found to be a very potent inhibitor of both human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) activity and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ebbfbe8d688d9fca8c0b76b7c068b4c
https://pubmed.ncbi.nlm.nih.gov/7692812
https://pubmed.ncbi.nlm.nih.gov/7692812
Autor:
C. Meichsner, R. Esser, Helga Rübsamen-Waigmann, H. von Briesen, K. Becker, Wolfram Brugger, Reinhard Andreesen
Publikováno v:
Research in virology. 141(2)
Because of the very important role of the mononuclear phagocyte system in the immunopathogenesis of HIV infection, a culture system for in vitro studies of infection of monocytes/macrophages with HIV was developed. A method is described for the infec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7296f6c262a2618289990e213c476445
https://pubmed.ncbi.nlm.nih.gov/1693221
https://pubmed.ncbi.nlm.nih.gov/1693221
Autor:
Herbert Kühnel, A. Immelmann, D. Mix, K. Henco, L. Biesert, Michalina Adamski, Renate Kreutz, H. Von Briesen, Ursula Dietrich, C. Meichsner
Publikováno v:
Proceedings of the National Academy of Sciences. 86:2383-2387
Human immunodeficiency virus type 2 (HIV-2)-related viruses were isolated from a Gambian dying of exclusively neurological disease (HIV-2D194) and from an asymptomatic Ghanian (HIV-2D205). Both strains exhibited properties of HIV-1 biological subtype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67bf8be9a3c7bd3092a2575650a1e491
https://doi.org/10.1073/pnas.86.7.2383
https://doi.org/10.1073/pnas.86.7.2383
Publikováno v:
The Journal of Antibiotics. 40:1762-1767
Cefotaxime (CTX) and HRE 664 (a novel penem antibiotic) possess complementary in vitro properties. Differences can be observed in their antibacterial spectra, their beta-lactamase stability and -inhibition, and their affinity to penicillin-binding pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baced5a67fd1f5c0effa72a3ef63f481
https://doi.org/10.7164/antibiotics.40.1762
https://doi.org/10.7164/antibiotics.40.1762
Publikováno v:
Europe PubMed Central
The human immunodeficiency virus type 1 (HIV-1)-specific reverse transcriptase (RT) inhibitor quinoxaline S-2720 showed a more-potent inhibitory effect on HIV-1-induced cytopathicity in CEM cells than either nevirapine, pyridinone L-697,661, bis-hete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa45e9d6f239a49144fe1fd34a565881
http://europepmc.org/abstract/med/7525984
http://europepmc.org/abstract/med/7525984