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Akademický článek

High-throughput identification of functional regulatory SNPs in systemic lupus erythematosus

Autor: Qiang Wang, Taehyeung Kim, Marta Martínez-Bonet, Vitor R. C. Aguiar, Sangwan Sim, Jing Cui, Jeffrey A. Sparks, Xiaoting Chen, Marc Todd, Brian Wauford, Miranda C. Marion, Carl D. Langefeld, Matthew T. Weirauch, Maria Gutierrez-Arcelus, Peter A. Nigrovic

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)

Abstract Genome-wide association studies implicate multiple loci in risk for systemic lupus erythematosus (SLE), but few contain exonic variants, rendering systematic identification of non-coding variants essential to decoding SLE genetics. We utiliz

Externí odkaz: https://doaj.org/article/1e3df32c4843408cb3495d4e0d4bcf9e

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Akademický článek

Molecular pathways identified from single nucleotide polymorphisms demonstrate mechanistic differences in systemic lupus erythematosus patients of Asian and European ancestry

Autor: Katherine A. Owen, Kristy A. Bell, Andrew Price, Prathyusha Bachali, Hannah Ainsworth, Miranda C. Marion, Timothy D. Howard, Carl D. Langefeld, Nan Shen, Jinoos Yazdany, Maria Dall’era, Amrie C. Grammer, Peter E. Lipsky

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)

Abstract Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disorder with a prominent genetic component. Individuals of Asian-Ancestry (AsA) disproportionately experience more severe SLE compared to individuals of European-Ancestry (EA),

Externí odkaz: https://doaj.org/article/1fef23b3319f4cc3907cb4906525e18f

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Akademický článek

The modifying influence of HLA class II DQB1∗06:02 on the Streptococcus and clinical phenotype correlation among anti-Ro+ mothers of children with neonatal lupus

Autor: Robert M. Clancy, Carla J. Guthridge, Miranda C. Marion, Joel Guthridge, Timothy D. Howard, Peter M. Izmirly, Mala Masson, Jill P. Buyon, Judith A. James, Carl D. Langefeld

Publikováno v: Genes and Diseases, Vol 10, Iss 4, Pp 1169-1171 (2023)

Externí odkaz: https://doaj.org/article/1636e4218aa0450893de7d1076fd72ac

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Akademický článek

Gut dysbiosis and the clinical spectrum in anti-Ro positive mothers of children with neonatal lupus

Autor: Robert M. Clancy, Miranda C. Marion, Hannah C. Ainsworth, Miao Chang, Timothy D. Howard, Peter M. Izmirly, Mala Masson, Jill P. Buyon, Carl D. Langefeld

Publikováno v: Gut Microbes, Vol 14, Iss 1 (2022)

Anti-SSA/Ro antibodies, while strongly linked to fetal cardiac injury and neonatal rash, can associate with a spectrum of disease in the mother, ranging from completely asymptomatic to overt Systemic Lupus Erythematosus (SLE) or Sjögren’s Syndrome

Externí odkaz: https://doaj.org/article/bcc621cc037c430b8873a4ca2de1499c

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Akademický článek

The morpho-sedimentology of an artificial roadstead (Cherbourg, France)

Autor: G. Gregoire, Y. Méar, E. Poizot, C. Marion, A. Murat, B. Hebert

Publikováno v: Journal of Maps, Vol 15, Iss 2, Pp 677-685 (2019)

Because of its size and geographical position, the Cherbourg roadstead appears as a favourable site for Marine Renewable Energy (MRE) industry. As a result, Cherbourg harbour has undergone profound changes (2015 and 2016) due to the installation of i

Externí odkaz: https://doaj.org/article/5e75395727eb4af0bdc254b7712c5ccf

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Akademický článek

How high energy fluxes may affect Rayleigh–Taylor instability growth in young supernova remnants

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-6 (2018)

Radiation and conduction are generally considered as the main energy transport mechanisms for the evolution of early supernova remnants. Here the authors experimentally show the role of electron heat transfer on the growth of Rayleigh–Taylor instab

Externí odkaz: https://doaj.org/article/f153b9b02a5a45d6934610dc34ba9b57

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Akademický článek

Transancestral mapping and genetic load in systemic lupus erythematosus

Autor: Carl D. Langefeld, Hannah C. Ainsworth, Deborah S. Cunninghame Graham, Jennifer A. Kelly, Mary E. Comeau, Miranda C. Marion, Timothy D. Howard, Paula S. Ramos, Jennifer A. Croker, David L. Morris, Johanna K. Sandling, Jonas Carlsson Almlöf, Eduardo M. Acevedo-Vásquez, Graciela S. Alarcón, Alejandra M. Babini, Vicente Baca, Anders A. Bengtsson, Guillermo A. Berbotto, Marc Bijl, Elizabeth E. Brown, Hermine I. Brunner, Mario H. Cardiel, Luis Catoggio, Ricard Cervera, Jorge M. Cucho-Venegas, Solbritt Rantapää Dahlqvist, Sandra D’Alfonso, Berta Martins Da Silva, Iñigo de la Rúa Figueroa, Andrea Doria, Jeffrey C. Edberg, Emőke Endreffy, Jorge A. Esquivel-Valerio, Paul R. Fortin, Barry I. Freedman, Johan Frostegård, Mercedes A. García, Ignacio García de la Torre, Gary S. Gilkeson, Dafna D. Gladman, Iva Gunnarsson, Joel M. Guthridge, Jennifer L. Huggins, Judith A. James, Cees G. M. Kallenberg, Diane L. Kamen, David R. Karp, Kenneth M. Kaufman, Leah C. Kottyan, László Kovács, Helle Laustrup, Bernard R. Lauwerys, Quan-Zhen Li, Marco A. Maradiaga-Ceceña, Javier Martín, Joseph M. McCune, David R. McWilliams, Joan T. Merrill, Pedro Miranda, José F. Moctezuma, Swapan K. Nath, Timothy B. Niewold, Lorena Orozco, Norberto Ortego-Centeno, Michelle Petri, Christian A. Pineau, Bernardo A. Pons-Estel, Janet Pope, Prithvi Raj, Rosalind Ramsey-Goldman, John D. Reveille, Laurie P. Russell, José M. Sabio, Carlos A. Aguilar-Salinas, Hugo R. Scherbarth, Raffaella Scorza, Michael F. Seldin, Christopher Sjöwall, Elisabet Svenungsson, Susan D. Thompson, Sergio M. A. Toloza, Lennart Truedsson, Teresa Tusié-Luna, Carlos Vasconcelos, Luis M. Vilá, Daniel J. Wallace, Michael H. Weisman, Joan E. Wither, Tushar Bhangale, Jorge R. Oksenberg, John D. Rioux, Peter K. Gregersen, Ann-Christine Syvänen, Lars Rönnblom, Lindsey A. Criswell, Chaim O. Jacob, Kathy L. Sivils, Betty P. Tsao, Laura E. Schanberg, Timothy W. Behrens, Earl D. Silverman, Marta E. Alarcón-Riquelme, Robert P. Kimberly, John B. Harley, Edward K. Wakeland, Robert R. Graham, Patrick M. Gaffney, Timothy J. Vyse

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)

Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong ethnic and gender bias. In a transancestral genetic association study, Langefeldet al. identify 24 novel regions associated with risk to lupus and propose a cumulative hits hyp

Externí odkaz: https://doaj.org/article/a68227bc3ba0457486591e4743061bf9

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