Zobrazeno 1 - 10
of 50
pro vyhledávání: '"C Marc Luetjens"'
Publikováno v:
Primate Biology. 7:1-4
Enhanced pre- and postnatal development (ePPND) studies have become the default developmental toxicity test for biopharmaceuticals if nonhuman primates represent the relevant species. Spontaneous pregnancy losses and infant deaths can be significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f3bc653dfff01233ebf3ac9a85b62c4
https://doi.org/10.5194/pb-7-1-2020
https://doi.org/10.5194/pb-7-1-2020
Autor:
Muriel Bellot, C. Marc Luetjens, Morten Bagger, Courtney Horvath, Esther Sutter, Anthony DeLise, Dominique Brees, José M. Carballido, Ratnakar Pingili, Krishnan Ramanathan, Bernd C. Kieseier, Kerstin Hellwig
Publikováno v:
Reproductive toxicology (Elmsford, N.Y.). 108
Knowledge of the impacts of the anti-CD20 monoclonal antibody ofatumumab on the developing immune system is limited. This study examined the effects of intravenous ofatumumab on pregnancy, parturition, and lactation, and on pre- and postnatal surviva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a189381fa70939c38c8505d9df9734
https://pubmed.ncbi.nlm.nih.gov/34942355
https://pubmed.ncbi.nlm.nih.gov/34942355
Publikováno v:
Toxicologic Pathology. 47:444-460
If nonhuman primates represent the only relevant species for nonclinical safety evaluation of biotechnology-derived products, male and female fertility effects can be assessed in repeat dose toxicity studies given that sexually mature monkeys are use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e56f1b25701902dc58c68515504a8c50
https://doi.org/10.1177/0192623319831009
https://doi.org/10.1177/0192623319831009
Publikováno v:
Reproductive toxicology (Elmsford, N.Y.). 95
The incidence of spontaneous pregnancy/infant losses is highly variable in long-tailed macaques (cynomolgus monkey), making it potentially difficult to ascertain test item-related effects in developmental toxicity studies. Therefore, pregnancy normog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f55b284772948d09885bd1c4217cf91
https://pubmed.ncbi.nlm.nih.gov/32413491
https://pubmed.ncbi.nlm.nih.gov/32413491
Autor:
C. Marc Luetjens, Gerhard F. Weinbauer
Male reproduction across the Order Primates (monkeys and men) comprises general principles but also highly specialized adaptions. Even within the same species family, reproductive features can vary substantially. Among the latter are different mating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a4987351084985ebfb44f53c36a9d4f
https://doi.org/10.1016/b978-0-12-809633-8.20515-3
https://doi.org/10.1016/b978-0-12-809633-8.20515-3
Publikováno v:
Reproductive Toxicology. 88:34-35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36cce5396abd8a7366dd1907a564ae2e
https://doi.org/10.1016/j.reprotox.2019.07.065
https://doi.org/10.1016/j.reprotox.2019.07.065
Publikováno v:
Endocrinology. 148:6062-6072
In most mammals, the gonads are under the control of the pituitary gonadotropins LH and FSH. However, in the common marmoset monkey Callithrix jacchus, no LH is detectable in the pituitary but chorionic gonadotropin (CG) instead, normally produced in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b72220b4ede2b97073ef22daa21d16f
https://doi.org/10.1210/en.2007-0825
https://doi.org/10.1210/en.2007-0825
In this chapter we review the data available on the use of marmosets as a valuable NHP model and report on histopathological specificities in a variety of organs. Based on the differences described, the marmoset model is discussed in the context of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f57401ee38df06b22e7580df64e99159
https://doi.org/10.1016/b978-0-12-417144-2.00023-8
https://doi.org/10.1016/b978-0-12-417144-2.00023-8
Autor:
Paul Barrow, Kathryn Bayne, Joerg Bluemel, Frank Brennan, Iris D. Bolton, Christopher J. Bowman, Wayne R. Buck, Leigh Ann Burns-Naas, David B. Burr, Jennifer A. Cann, Annick J. Cauvin, Joy A. Cavagnaro, Ulrich Certa, Kathryn Chapman, Gary J. Chellman, Timothy P. Coogan, Jessica Couch, Lolke de Haan, Thierry Decelle, Annie Delaunois, Raffaella Faggioni, Betsy Ferguson, John Finch, Virginia Fisher, Werner Frings, Thomas Gelzleichter, Andreas Gschwind, Robert Hall, Wendy G. Halpern, Tobias Heckel, Kristin L. Henson, Susan Henwood, Jonathan R. Heyen, William Oliver Iverson, Mary Jeanne Kallman, Joachim Kaspareit, Tina Koban, Sven Korte, Pierre Lainée, Michael W. Leach, Lynne LeSauteur, Anne D. Lewis, Beatriz Silva Lima, Yanfei L. Ma, Keith G. Mansfield, C. Marc Luetjens, Pauline L. Martin, Kerstin Mätz-Rensing, Lars Fris Mikkelsen, Barbara Mounho-Zamora, Wolfgang Müller, Dennis J. Murphy, Marc Niehoff, Birgit Niggemann, Helen Palmer, Daniel J. Patrick, Christopher Peters, Marie-Soleil Piché, Mark Prescott, Kamm Prongay, Marlon C. Rebelatto, Alexandre Reymond, Laura Richman, Christian Roos, Lorin K. Roskos, Chandrassegar Saravanan, Vito G. Sasseville, Emanuel Schenck, Georg Schmitt, Jacintha M. Shenton, Anjali Singh, Matthew Skinner, David Glenn Smith, Markus Stephan-Gueldner, Marque Todd, Chih-Ming L. Tseng, John L. Vahle, Jean-Pierre Valentin, Hugo M. Vargas, Eric Wakshull, Lutz Walter, Gerhard F. Weinbauer, Joachim Wistuba, Harry Yang, Dietmar Zinner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cc7e40da8c9c9a862d5e68f270d49f3
https://doi.org/10.1016/b978-0-12-417144-2.09993-5
https://doi.org/10.1016/b978-0-12-417144-2.09993-5