Zobrazeno 1 - 10
of 20
pro vyhledávání: '"C M Shipman"'
Autor:
C M Shipman, Steven P. Luckman, H L Benford, Roslin Russell, Michael J. Rogers, Peter I. Croucher, Herbert Fleisch, Julie C. Frith, Fraser P. Coxon
Publikováno v:
ResearcherID
Scopus-Elsevier
Scopus-Elsevier
Bisphosphonates are chemically stable analogs of inorganic pyrophosphate, which are resistant to breakdown by enzymatic hydrolysis. The biological effects of bisphosphonates on calcium metabolism were originally ascribed to their physico-chemical eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5fccf1519b2655a9718bb9d7245d9bd
https://ora.ox.ac.uk/objects/uuid:be5ffeb7-ced3-440e-bdfe-5b5f9a268ff8
https://ora.ox.ac.uk/objects/uuid:be5ffeb7-ced3-440e-bdfe-5b5f9a268ff8
Autor:
Michael J. Rogers, Peter I. Croucher, Karin Vanderkerken, R. Graham, G. Russell, C M Shipman, B Van Camp
Bisphosphonates are a class of anti-resorptive drugs, which are effective in the treatment of osteoclast-mediated bone disease, including the osteolytic bone disease. which is a major clinical feature of patients with multiple myeloma. Recently, incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f069775e0171894d8421b2af7411fbc0
https://ora.ox.ac.uk/objects/uuid:20d3afb5-292c-4bbe-8c5a-374e70def4ad
https://ora.ox.ac.uk/objects/uuid:20d3afb5-292c-4bbe-8c5a-374e70def4ad
Multiple myeloma is a haematological malignancy characterized by an expansion of malignant plasma cells within the bone marrow and is frequently associated with bone disease involving the development of osteolytic bone lesions, pathological fractures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8722a53f71a57bef7bf92f7ffce82353
https://ora.ox.ac.uk/objects/uuid:6298a869-0247-40bb-8e7f-14d639a95c99
https://ora.ox.ac.uk/objects/uuid:6298a869-0247-40bb-8e7f-14d639a95c99
Autor:
Ingunn Holen, C M Shipman
Publikováno v:
Clinical Science. 110:279-291
OPG (osteoprotegerin), a secreted member of the TNF (tumour necrosis factor) receptor superfamily, has a variety of biological functions which include the regulation of bone turnover. OPG is a potent inhibitor of osteoclastic bone resorption and has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b799aed8264e0081a87ebc0535d08a9
https://doi.org/10.1042/cs20050175
https://doi.org/10.1042/cs20050175
Autor:
Annemieke Meijer, R. Graham G. Russell, C M Shipman, Anke J. Roelofs, Philippa A. Hulley, Frank H. Ebetino
Publikováno v:
International Journal of Cancer. 119:1254-1261
Bisphosphonates (BPs) are widely used in the treatment of osteolytic bone disease associated with multiple myeloma, and have been demonstrated to exert antitumor effects both in vitro and in vivo. However, the precise molecular mechanisms involved in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24f26d8081732444f8c005f6efaf3074
https://doi.org/10.1002/ijc.21977
https://doi.org/10.1002/ijc.21977
Publikováno v:
BoneKEy-Osteovision. 2:17-25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff42c5abf46759654beb1e30fe7b588b
https://doi.org/10.1138/20050161
https://doi.org/10.1138/20050161
Publikováno v:
British Journal of Cancer
ResearcherID
ResearcherID
Bisphosphonates are well established in the management of breast-cancer-induced bone disease. Recent studies have suggested that these compounds are effective in preventing the development of bone metastases. However, it is unclear whether this refle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1ca1e8faeb819463d0b4cbe06c8e13
http://europepmc.org/articles/PMC2363858
http://europepmc.org/articles/PMC2363858
Publikováno v:
The Molecular Basis of Skeletogenesis: Novartis Foundation Symposium 232
Scopus-Elsevier
Scopus-Elsevier
Clinical disorders in which bone resorption is increased are very common and include Paget's disease of bone, osteoporosis, and the bone changes secondary to cancer, such as occur in myeloma and metastases from breast cancer. Clinical disorders of re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f165f4fa103b46abaa206abba1cd231
https://doi.org/10.1002/0470846658.ch17
https://doi.org/10.1002/0470846658.ch17
Autor:
R M Locklin, Iannis E. Adamopoulos, S G Sun, N A Athanasou, James R. Edwards, C M Shipman, Afsie Sabokbar
Publikováno v:
Arthritis and rheumatism. 54(5)
Objective Human osteoclast formation from mononuclear phagocyte precursors involves interactions between tumor necrosis factor (TNF) ligand superfamily members and their receptors. LIGHT is a transmembrane protein expressed and shed from the surface
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e0066c4903e94e297a988d8b763296
https://pubmed.ncbi.nlm.nih.gov/16649193
https://pubmed.ncbi.nlm.nih.gov/16649193
Publikováno v:
Expert opinion on pharmacotherapy. 6(16)
Multiple myeloma is the second most common adult haematological malignancy. One of the major clinical features is the development of a unique osteolytic bone disease, characterised by progressive and devastating bone destruction, bone pain, pathologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148690e870a46b00c747e682fd6d0517
https://pubmed.ncbi.nlm.nih.gov/16318429
https://pubmed.ncbi.nlm.nih.gov/16318429