Zobrazeno 1 - 10
of 47
pro vyhledávání: '"C M Hohl"'
Publikováno v:
Journal of Neurochemistry. 71:535-548
The purpose of this study was to determine the mechanism by which adenosine, inosine, and guanosine delay cell death in glial cells (ROC-1) that are subjected to glucose deprivation and mitochondrial respiratory chain inhibition with amobarbital (GDM
Autor:
C. M. Hohl
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 276:H1502-H1510
The purpose of this study was to examine in situ regulation of AMP deaminase in newborn piglet cardiac myocytes and to determine its role in nucleotide metabolism during ischemia. When a rapid deenergization paradigm was used to assay AMP deaminase,
Publikováno v:
Journal of Cellular Biochemistry. 73:259-277
The chemotherapeutic, doxorubicin, is currently used empirically in the treatment of AIDS- related Kaposi's sarcoma (AIDS-KS). Although often employed in a chemotherapeutic cocktail (doxorubicin, bleomycin, vincristine) single-agent therapy has recen
Autor:
Aaron M. Hohl, C. M. Hohl
Publikováno v:
Molecular and Cellular Biochemistry. 201:151-158
The properties of piglet cardiac AMP deaminase were determined and its regulation by pH, phosphate, nucleotides and phosphorylation is described. AMP deaminase purified from the ventricles of newborn piglet hearts displayed hyperbolic kinetics with a
Publikováno v:
Journal of Cellular Biochemistry. 68:339-354
Both clinical and experimental evidence indicates that AIDS-related Kaposi's sarcoma (AIDS-KS) has a multifactorial pathogenesis with factors such as HIV viral load, latent virus induction, and opportunistic infections contributing to disease progres
Publikováno v:
Circulation. 96:1914-1922
Background The ventricular myocardium contains functional β 2 -adrenergic receptors that when activated increase intracellular Ca 2+ transients. Because elevated Ca 2+ has been implicated in the induction of ventricular fibrillation (VF), it is poss
Publikováno v:
Journal of Molecular and Cellular Cardiology. 29:1037-1043
First-generation Ca 2+ channel antagonists depress myocardial contractility, but many of the newer Ca 2+ channel blockers have a high degree of “vascular selectivity”. This study compares the effects of the Ca 2+ antagonists felodipine, amlodipin
Autor:
Larry R. Jones, George E. Billman, J. Hensley, Ruth A. Altschuld, Edward G. Lakatta, Rui-Ping Xiao, Richard H. Fertel, Pierre Marie L. Robitaille, C. M. Hohl, Robert L. Hamlin, L. C. Castillo, Randall C. Starling
Publikováno v:
Circulation. 92:1612-1618
Background Failing human hearts lose β 1 - but not β 2 -adrenergic receptors. In canine hearts with tachypacing failure, the ratio of β 2 - to β 1 -adrenergic receptors is increased. The present study was designed to determine whether heart failu
Publikováno v:
Journal of Molecular and Cellular Cardiology. 27:523-530
We examined contractile performance in perfused ventricles from normal rats and from SHHF/Mccfacp rats with end-stage heart failure. Changes in pacing frequency from 3 to 5 Hz evoked a complex response in normal rat myocardium. The first beat after a
Autor:
Beth Livingston, Benedetta Tantini, Edward G. Lakatta, Larry R. Jones, Ruth A. Altschuld, Rui-Ping Xiao, Bruce D. Ziman, C. M. Hohl
Publikováno v:
Journal of Biological Chemistry. 269:19151-19156
Previous studies have shown that both beta 1- and beta 2-adrenergic receptors (AR) are present in rat ventricular myocytes, but stimulation of these receptor subtypes elicits qualitatively different cellular responses (Xiao, R.-P., and Lakatta, E. G.