Výsledky vyhledávání - "C M Heldebrant"

Human coagulation factor IX: assessment of thrombogenicity in animal models and viral safety

Autor: S W, Herring, C, Abildgaard, K T, Shitanishi, J, Harrison, S, Gendler, C M, Heldebrant

Publikováno v: The Journal of laboratory and clinical medicine. 121(3)

Thromboembolic complications associated with prothrombin complex concentrate treatment may be related to the high levels of factors II and X in these products. We report here results from preclinical safety studies with a human coagulation factor IX

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c07ccf2859bddeedae450bcce5d83518
https://pubmed.ncbi.nlm.nih.gov/8445288

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The fibrinolytic potential of the normal primate following the generation of thrombin in vivo

Autor: A R, Giles, M E, Nesheim, S W, Herring, H, Hoogendoorn, D C, Stump, C M, Heldebrant

Publikováno v: Thrombosis and haemostasis. 63(3)

Parameters of the fibrinolytic system were studied in a primate model where the generation of thrombin was promoted in vivo. The procoagulant stimulus used was a combination of human factor Xa in combination with phosphatidylcholine/phosphatidylserin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d013eb0d02356989acc58ab9653dd52f
https://pubmed.ncbi.nlm.nih.gov/2402750

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Evaluation of two viral inactivation methods for the preparation of safer factor VIII and factor IX concentrates

Autor: J S McDougal, E Muchmore, S Jordan, C M Heldebrant, D S Hwang, Edward D. Gomperts, A E Friedman, E Sergis-Davenport, R. Miller, C K Kasper

Publikováno v: Transfusion. 25:510-515

We report here the results of our evaluation of two procedures to eliminate viruses in factor VIII and factor IX coagulation factor concentrates. Both procedures were equally effective in the in vitro destruction of marker viruses. However, in a cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcdf95f1476b4f4ea440a31f1ae34bcc
https://doi.org/10.1046/j.1537-2995.1985.25686071421.x

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Evaluation of human viral disease transmission through plasma products

Autor: C M, Heldebrant, A E, Friedman, E J, Fedor

Publikováno v: Developments in biological standardization. 67

Alpha's Wet Heat-Treatment process is being applied to both Factor VIII (AHF) and Factor IX Complex (PTC). Twelve hemophilia A, five hemophilia B, and one von Willebrands patient have been followed for at least 6 months for evidence of non-A, non-B h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cf39a2715051d8d0b3665c4a7161d432
https://pubmed.ncbi.nlm.nih.gov/2440744

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