Výsledky vyhledávání

Inhibition of stimulated Jurkat cell adenosine 3',5'-cyclic monophosphate synthesis by the immunomodulatory compound HR325

Autor: A P, Curnock, T A, Thomson, R, Westwood, E A, Kuo, R A, Williamson, C M, Yea, E, Ruuthb

Publikováno v: Biochemical pharmacology. 61(2)

HR325 (2-cyano-3-cyclopropyl-3-hydroxy-N-[3'-methyl-4'(trifluoromethyl)-phenyl]-propenamide) is an immunomodulatory compound through pyrimidine biosynthesis inhibition with antiproliferative properties which was derived from the isoxazol compound A77

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a2062666249248a5a516772e012297b5
https://pubmed.ncbi.nlm.nih.gov/11163337

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Potencies of leflunomide and HR325 as inhibitors of prostaglandin endoperoxide H synthase-1 and -2: comparison with nonsteroidal anti-inflammatory drugs

Autor: A P, Curnock, P A, Robson, C M, Yea, D, Moss, S, Gadher, T A, Thomson, R, Westwood, E, Ruuth, R A, Williamson

Publikováno v: The Journal of pharmacology and experimental therapeutics. 282(1)

The relative anti-inflammatory activities of the immunomodulators HR325 and leflunomide, or its active metabolite A77 1726, were examined by determining potencies in vitro on prostaglandin endoperoxide H synthase (PGHS) and in vivo in rat air pouch i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::22626f2d8a609b0a3cc88d13782a965e
https://pubmed.ncbi.nlm.nih.gov/9223572

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Dihydroorotate dehydrogenase is a target for the biological effects of leflunomide

Autor: R A, Williamson, C M, Yea, P A, Robson, A P, Curnock, S, Gadher, A B, Hambleton, K, Woodward, J M, Bruneau, P, Hambleton, S, Spinella-Jaegle, P, Morand, O, Courtin, C, Sautés, R, Westwood, T, Hercend, E A, Kuo, E, Ruuth

Publikováno v: Transplantation proceedings. 28(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::750bde00bce34adf3759b41e9842c707
https://pubmed.ncbi.nlm.nih.gov/8962196

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Inhibition of myeloperoxidase by synovial fluid and serum

Autor: C J Elson, B Dularay, C. M. Yea

Publikováno v: Annals of the rheumatic diseases. 50(6)

An inhibitor of myeloperoxidase has been identified in the synovial fluids and sera from patients with rheumatoid arthritis and sera from normal subjects. Initially, these fluids were found to inhibit stimulus induced degranulation of polymorphonucle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fabd69e35749159152668b6042854edd
https://pubmed.ncbi.nlm.nih.gov/1647755

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Identification of a myeloperoxidase inhibitor from normal human serum

Autor: Christopher J. Elson, B Dularay, C. M. Yea

Publikováno v: Clinical and experimental immunology. 84(2)

SUMMARY An inhibitor of myeloperoxidase (MPO) has been identified in normal human serum. Initial experiments confirmed that high levels of MPO inhibitory activity are present in sera and that the inhibitor did not act by interfering with the assay. P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::856bd62b850679ecf93c466ef027cf45
https://pubmed.ncbi.nlm.nih.gov/1851058

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Purification and some properties of the 45 kDa diphenylene iodonium-binding flavoprotein of neutrophil NADPH oxidase

Autor: Andrew R. Cross, Owen T.G. Jones, C M Yea

The 45 kDa diphenylene iodonium-binding flavoprotein of the human neutrophil superoxide-generating oxidase has been purified by affinity chromatography. The polypeptide was eluted from Blue Memsep or 2′,5′-ADP-agarose columns with either NADP or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1f6ccbc0a381ca7969383bf529fe84
https://europepmc.org/articles/PMC1136618/

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