Increased gastrin-releasing peptide (GRP) receptor expression in tumour cells confers sensitivity to [Arg6,D-Trp7,9,NmePhe8]-substance P (6–11)-induced growth inhibition

Autor: Tariq Sethi, Alison C. MacKinnon, C M Waters, U Tufail-Hanif, Duncan I. Jodrell, Jeffrey Cummings, Christopher Haslett

Publikováno v: British Journal of Cancer
Waters, C M, Mackinnon, A C, Cummings, J, Tufail-hanif, U, Jodrell, D, Haslett, C & Sethi, T 2003, ' Increased gastrin-releasing peptide (GRP) receptor expression in tumour cells confers sensitivity to [Arg6,D-Trp7,9,NmePhe8]-substance P (6-11)-induced growth inhibition ', British Journal of Cancer, vol. 88, no. 11, pp. 1808-1816 . https://doi.org/10.1038/sj.bjc.6600957

[Arg(6),D-Trp(7,9),N(me)Phe(8)]-substance P (6-11) (SP-G) is a novel anticancer agent that has recently completed phase I clinical trials. SP-G inhibits mitogenic neuropeptide signal transduction and small cell lung cancer (SCLC) cell growth in vitro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae7800ce94bf155ece1bce93b186967
http://europepmc.org/articles/PMC2377129

The role of N-methyl-d-aspartate-type glutamatergic neurotransmission in the photic induction of immediate-early gene expression in the suprachiasmatic nuclei of the Syrian hamster

Autor: Michael H. Hastings, Francis J. P. Ebling, G. I. Evant, E. S. Maywood, Trevor Humby, David C. Hancock, C. M. Waters, K. Staley

Publikováno v: ResearcherID

This study investigated the role of N-methyl-D-aspartate (NMDA)-type glutamatergic neurotransmission in mediating the photic induction of immediate-early gene expression in the Suprachiasmatic nucleus (SCN) of the Syrian hamster. Activation of c-fos,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789bc27278c94ee54b49bd5937f97d29
https://pubmed.ncbi.nlm.nih.gov/19215534

Keratinocyte growth factor accelerates wound closure in airway epithelium during cyclic mechanical strain

Autor: C M, Waters, U, Savla

Publikováno v: Journal of cellular physiology. 181(3)

The airway epithelium may be damaged by inhalation of noxious agents, in response to pathogens, or during endotracheal intubation and mechanical ventilation. Maintenance of an intact epithelium is important for lung fluid balance, and the loss of epi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::72ed18aac807d7856c3300cdcdeb8e26
https://pubmed.ncbi.nlm.nih.gov/10528228

[Arg6,D-Trp7,9,NmePhe8]-substance P (6-11) activates JNK and induces apoptosis in small cell lung cancer cells via an oxidant-dependent mechanism

Autor: R A Armstrong, Tariq Sethi, Christopher Haslett, Alison C. MacKinnon, C M Waters, Jeffrey Cummings, John F. Smyth

Publikováno v: British Journal of Cancer

[Arg6,D-Trp7,9,NmePhe8]-substance P (6–11) (antagonist G) is a novel class of anti-cancer agent that inhibits small-cell lung cancer (SCLC) cell growth in vitro and in vivo and is entering phase II clinical investigation for the treatment of SCLC.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::680ba61044d9cf376119ea6e3abeaaac
https://pubmed.ncbi.nlm.nih.gov/10362111

Uptake of fentanyl in pulmonary endothelium

Autor: C M, Waters, M J, Avram, T C, Krejcie, T K, Henthorn

Publikováno v: The Journal of pharmacology and experimental therapeutics. 288(1)

Fentanyl is a basic amine shown to have extensive first-pass pulmonary uptake. To evaluate the role of the pulmonary endothelium in this uptake process, the simultaneous pharmacokinetics of [3H]fentanyl and two marker drugs, blue dextran, and [14C]an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::29ae1ebe6bf616d67b636688202daf06
https://pubmed.ncbi.nlm.nih.gov/9862766