Výsledky vyhledávání - "C M, Tsoukas"

Selection of Molecular Descriptors with Artificial Intelligence for the Understanding of HIV-1 Protease Peptidomimetic Inhibitors-activity

Autor: C. M. Tsoukas, C. Boucher, Kuo-Chen Chou, G. E. Hatzakis, Dong-Qing Wei, Suzanne Sirois

Publikováno v: Medicinal Chemistry. 1:173-184

Quantitative Structure Activity Relationship (QSAR) techniques are used routinely by computational chemists in drug discovery and development to analyze datasets of compounds. Quantitative numerical methods like Partial Least Squares (PLS) and Artifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c98fad9d62cf1ef4a62e031109419971
https://doi.org/10.2174/1573406053175238

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Predictors of unstructured antiretroviral treatment interruption and resumption among HIV-positive individuals in Canada

Autor: H, Samji, T E, Taha, D, Moore, A N, Burchell, A, Cescon, C, Cooper, J M, Raboud, M B, Klein, M R, Loutfy, N, Machouf, C M, Tsoukas, J S G, Montaner, R S, Hogg, Benita, Yip

Publikováno v: HIV medicine. 16(2)

Sustained optimal use of combination antiretroviral therapy (cART) has been shown to decrease morbidity, mortality and HIV transmission. However, incomplete adherence and treatment interruption (TI) remain challenges to the full realization of the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c7fcaabb5f35e707013148eeccdbb2d2
https://pubmed.ncbi.nlm.nih.gov/25174373

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Low urine pH is associated with reduced indinavir crystalluria in indinavir-treated HIV-infected individuals

Autor: A I Alli, A K Watters, Raymonde F. Gagnon, C M Tsoukas, M D Edwardes

Publikováno v: Clinical nephrology. 65(1)

Indinavir is a potent HIV-1 protease inhibitor included in current antiretroviral therapeutic regimens. It is associated with renal and urological complications ascribed to indinavir crystalluria. We have previously reported that indinavir crystallur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::809c5482fa02f8987c13648b153c252c
https://pubmed.ncbi.nlm.nih.gov/16429837

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Symptomatic and health status outcomes in the Canadian randomized MAC treatment trial (CTN010). Canadian HIV Trials Network Protocol 010 Study Group

Autor: J, Singer, A, Thorne, S, Khorasheh, J M, Raboud, A W, Wu, I, Salit, C M, Tsoukas, C, Lemieux, S D, Shafran

Publikováno v: International journal of STDAIDS. 11(4)

Our objective was to compare the effect of 2 regimens for treatment of Mycobacterium avium complex (MAC) bacteraemia in an HIV-positive population on symptoms and health status outcomes using a substudy of an open-label randomized controlled trial. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::98bf6f1ee7ffc437a33f751123855324
https://pubmed.ncbi.nlm.nih.gov/10772083

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Effect of splenectomy on T-cell subsets and plasma HIV viral titers in HIV-infected patients

Autor: N F, Bernard, D N, Chernoff, C M, Tsoukas

Publikováno v: Journal of human virology. 1(5)

In previous studies we have shown that removal of the spleen in HIV-infected people during the asymptomatic phase of disease results in slower time to AIDS and may also result in improved survival. In this paper, we examine whether splenectomy affect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2676478edae4e8b8f986fb05262ca732
https://pubmed.ncbi.nlm.nih.gov/10195261

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Activity of the soft gelatin formulation of saquinavir in combination therapy in antiretroviral-naive patients. NV15355 Study Team

Autor: R T, Mitsuyasu, P R, Skolnik, S R, Cohen, B, Conway, M J, Gill, P C, Jensen, J J, Pulvirenti, L N, Slater, R T, Schooley, M A, Thompson, R A, Torres, C M, Tsoukas

Publikováno v: AIDS (London, England). 12(11)

A Phase II, open-label, randomized, parallel-arm, multicentre trial to compare the antiviral activity and safety of two formulations of saquinavir (SQV), soft gelatin (SQV-SGC) and hard gelatin (SQV-HGC) capsules, in combination with two nucleoside r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::325d535751b2976575b845a794049c24
https://pubmed.ncbi.nlm.nih.gov/9708399

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Akademický článek

A density functional study of the hydrogen-bond network within the HIV-1 protease catalytic site cleft.

Autor: S. Sirois, E. I. Proynov, J.-F. Truchon, C. M. Tsoukas, D. R. Salahub

Publikováno v: Journal of Computational Chemistry; 2003, Vol. 24 Issue 9, p1110, 10p

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Lack of transmission of HIV through human bites and scratches

Autor: C M, Tsoukas, T, Hadjis, J, Shuster, L, Theberge, P, Feorino, M, O'Shaughnessy

Publikováno v: Journal of acquired immune deficiency syndromes. 1(5)

To examine the relative risk of transmission of the human immuno-deficiency virus (HIV) through bites and scratches, we studied 198 health care workers, 30 of whom were traumatized in this fashion while caring for an aggressive AIDS patient. This vio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::da5dcedf1639406c7bbeb546ac74fbd2
https://pubmed.ncbi.nlm.nih.gov/3221322

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Akademický článek

Synthesis of α-cyanato-α′-carbonyl sulfoxonium ylides in water.

Autor: Zhang, Qingyao, Luo, Cankun, Lai, Ruizhi, Lin, Zhiqian, Jia, Pengfei, Xu, Shuran, Guo, Li, Wu, Yong

Publikováno v: Green Chemistry; 9/21/2023, Vol. 25 Issue 18, p7068-7072, 5p

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