Výsledky vyhledávání - "C M, Thonoor"

Disposition and pharmacokinetics of temozolomide in rat

Autor: Vijay Batra, James E. Patrick, Paul Statkevich, Larisa Reyderman, C. M. Thonoor, Mark A. Wirth

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 34(5)

1. Temozolomide, an imidazotetrazine derivative, is a cytotoxic alkylating agent of broad-spectrum antitumour activity. The absorption, metabolism, distribution and excretion of temozolomide have been investigated in male and female Sprague-Dawley an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0377e07913e5d867d60514d7510d8ee9
https://pubmed.ncbi.nlm.nih.gov/15370964

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In vitro metabolism of 10-(3-chlorophenyl)-6,8,9,10-tetrahydrobenzo[b][1,8]naphthyridin-5(7H)- one, a topical antipsoriatic agent. Use of precision-cut rat, dog, monkey and human liver slices, and chemical synthesis of metabolites

Autor: S, Zbaida, Y, Du, D, Shannon, D, Laudicina, C M, Thonoor, K, Ng, N, Blumenkrantz, J E, Patrick, M N, Cayen, R, Friary, V, Seidl, T M, Chan, B, Pramanik, M, Spangler, A T, McPhail

Publikováno v: Biopharmaceuticsdrug disposition. 19(5)

The metabolism of SCH 40120, which is the clinically effective antipsoriatic drug 10-(3-chlorophenyl)-6,8,9,10-tetrahydrobenzol[b][1,8]naphthyrid in-5(7H)-one, was determined in vitro. Rat, dog, cynomolgus monkey, and human liver slices hydroxylated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8ff37b32dd3bce5534f6784fe09659dc
https://pubmed.ncbi.nlm.nih.gov/9673784

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Biodistribution and radiation dosimetry of radioiodinated-SCH 23982, a potential dopamine D-1 receptor imaging agent

Autor: C M, Thonoor, M W, Couch, D M, Greer, K D, Thomas, C M, Williams

Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 29(10)

Radioiodinated-SCH 23982 is a potential agent for the imaging of dopamine D-1 receptors in the human brain. In vivo binding of [125I]SCH 23982 to D-1 receptors in rat brain was determined over 4 hr. The ratio of activity in striatum and frontal corte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fd6861840821995cac8bc50c82b51fb4
https://pubmed.ncbi.nlm.nih.gov/3262726

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Activities of octopamine and synephrine stereoisomers on alpha-adrenoceptors

Autor: J.W. O'Brien, C. M. Brown, V.G. Wilson, A. G. B. Muir, Clyde M. Williams, C. M. Thonoor, John M. Midgley, John C. McGrath

Publikováno v: British journal of pharmacology. 93(2)

1. The activities of the (-)- and (+)-forms of m- and p-octopamine and m- and p-synephrine on alpha 1-adrenoceptors from rat aorta and anococcygeus and alpha 2-adrenoceptors from rabbit saphenous vein were compared with those of noradrenaline (NA). 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::837ef55dc057b9d95632cb40cc90a238
https://pubmed.ncbi.nlm.nih.gov/2833972

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