Zobrazeno 1 - 10
of 10
pro vyhledávání: '"C M, Picone"'
Autor:
James C. Grotta, P. T. Ostrow, John R. Dedman, L. P. Yao, Howard M. Rhoades, Roger Strong, C. M. Picone, R. M. Earls
Publikováno v:
Annals of Neurology. 27:612-619
We evaluated several doses of cis-4-(phosphonomethyl)-2-piperidine-carboxylic acid (CGS-19755), a potent competitive N-methyl-D-aspartate (NMDA) receptor antagonist, systemically administered either before or after 20 to 30 minutes of global ischemia
Autor:
James C. Grotta, C M Picone, A T Grotta, P. Ostrow, Howard M. Rhoades, L C Pettigrew, Roger Strong, D M Rosenbaum
Publikováno v:
Stroke. 21:138-140
Presynaptic release of glutamate into the extracellular compartment and activation of receptor-operated calcium channels may contribute to ischemic neuronal damage. We evaluated the effect of baclofen, a selective inhibitor of presynaptic glutamate r
Autor:
Roger Strong, L. P. Yao, R. M. Earls, C. M. Picone, T. J. DeGraba, John R. Dedman, James C. Grotta, P T Ostrow, Howard M. Rhoades
Publikováno v:
Cerebral Ischemia and Dementia ISBN: 9783642762109
Activation of N-methyl-D-aspartate (NMDA) receptors by ischemia-induced glutamate release results in the entry of ionic calcium into neurons, followed by progressive neuronal damage by calcium-activated enzyme systems and delayed cell death. Earlier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::541b37d5fa8ead84b09cf73cbd784e4c
https://doi.org/10.1007/978-3-642-76208-6_23
https://doi.org/10.1007/978-3-642-76208-6_23
Publikováno v:
Stroke. 21
We correlated the efficacy of several clinically relevant pharmacotherapies with their ability to prevent calcium influx into neurons and subsequent binding to calmodulin. We studied the administration of CGS 19755, nimodipine, nicardipine, and combi
Autor:
D M, Rosenbaum, J C, Grotta, F M, Yatsu, C M, Picone, L C, Pettigrew, P, Bratina, J, Zabramski, R, Spetzler, L, Lopez, J, Marler
Publikováno v:
Angiology. 41(11 Pt 2)
The author performed a pilot study of nicardipine (NC), a Ca(+)+ channel blocker, to study its dosing, toxicity, and possible efficacy for hemispheric cerebral infarction within 12 hours (mean 6.9 hr) of onset to determine the advisability of proceed
Publikováno v:
Stroke. 21(6)
Calcium channel blockers such as nicardipine improve outcome after global cerebral ischemia and may attenuate ischemic neuronal injury by preventing calcium influx and binding to calmodulin. We followed the temporal and regional sequence of neuronal
Publikováno v:
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 9(6)
Since ionic Ca2+binds with intracellular calmodulin (CaM) before activating proteases, kinases, and phospholipases, demonstration of persistent Ca2+–CaM binding in neurons destined to show ischemic cellular injury would support the concept that ele
Autor:
J. Marlar, L. Lopez, L. C. Pettigrew, Frank M. Yatsu, James C. Grotta, J. Zabramski, Patti Bratina, D. Ellis, C. M. Picone, D. M. Rosenbaum, R. Spetzler
Publikováno v:
Cerebral Ischemia and Calcium ISBN: 9783642858659
Interest in the therapy for acute cerebral ischemia has been stimulated by the demonstration of threatened but potentially viable tissue in experimental models [11, 12] and in stroke patients [1, 3, 6]. One strategy for preserving function in these b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1159cd38e11022899ae67312d37b7a81
https://doi.org/10.1007/978-3-642-85863-5_47
https://doi.org/10.1007/978-3-642-85863-5_47
Publikováno v:
Annals of neurology. 25(6)
A variety of eyelid movement abnormalities have been attributed to lesions of the central nervous system. Apraxia of lid movements, and especially of lid opening, has received the least attention. We present 2 cases of lid opening apraxia and propose
Autor:
P. Bratina, C M Picone, P. M. Yatsu, L C Pettigrew, H. Rhoades, R. Alam, James C. Grotta, D. Vital, R. Earls
Publikováno v:
Neurology. 39:1325-1325
We followed 19 men and 19 women with asymptomatic carotid stenosis up to 30 months to determine whether hematologic or lipid abnormalities could identify those individuals developing progressing carotid atherosclerosis (defined as an increase in mean