Zobrazeno 1 - 10
of 121
pro vyhledávání: '"C M, Pearson"'
Autor:
Laura J. Norton, Samantha Hallal, Elizabeth S. Stout, Alister P. W. Funnell, Richard C. M. Pearson, Merlin Crossley, Kate G. R. Quinlan
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract The Krüppel-like factor (KLF) family of transcription factors play critical roles in haematopoiesis. KLF1, the founding member of the family, has been implicated in the control of both erythropoiesis and megakaryopoiesis. Here we describe a
Externí odkaz:
https://doaj.org/article/a37d4ae2beb44fd8a42326855e39b724
Publikováno v:
Inflammopharmacology. 29:367-376
1. A strategy is described for evaluating drugs against different phases in the development of an auto allergic disease, experimental allergic encephalomyelitis. It is based on a cell transfer technique whereby the disease is passively transferred wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f74f6f665ae342d0ac5927cbcaa0f649
https://doi.org/10.1007/s10787-019-00565-w
https://doi.org/10.1007/s10787-019-00565-w
Autor:
M, Rodrigues, P, Bhattacharjee, A, Brinkmalm, D T, Do, C M, Pearson, S, De, A, Ponjavic, J A, Varela, K, Kulenkampff, I, Baudrexel, D, Emin, F S, Ruggeri, J E, Lee, A R, Carr, T P J, Knowles, H, Zetterberg, T N, Snaddon, S, Gandhi, S F, Lee, D, Klenerman
Publikováno v:
Nature chemistry. 14(9)
The composition of soluble toxic protein aggregates formed in vivo is currently unknown in neurodegenerative diseases, due to their ultra-low concentration in human biofluids and their high degree of heterogeneity. Here we report a method to capture
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::97e41741e94288a6c7691d98bce9e95f
https://pubmed.ncbi.nlm.nih.gov/35798951
https://pubmed.ncbi.nlm.nih.gov/35798951
Autor:
Alister P. W. Funnell, Manan Shah, Richard C. M. Pearson, Laura J. Norton, Yukio Nakamura, Gabriella E. Martyn, Merlin Crossley, Jon Burdach, Lu Yang, Kate G. R. Quinlan, Beeke Wienert, Ryo Kurita
Publikováno v:
Nature Genetics. 50:498-503
β-hemoglobinopathies such as sickle cell disease (SCD) and β-thalassemia result from mutations in the adult HBB (β-globin) gene. Reactivating the developmentally silenced fetal HBG1 and HBG2 (γ-globin) genes is a therapeutic goal for treating SCD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d35e0a591f76b1aa13a35f917df59f5e
https://doi.org/10.1038/s41588-018-0085-0
https://doi.org/10.1038/s41588-018-0085-0
Publikováno v:
International Journal of Cell Biology, Vol 2011 (2011)
Haemoglobinopathies such as thalassaemia and sickle cell disease present a major health burden. Currently, the main forms of treatment for these diseases are packed red blood cell transfusions and the administration of drugs which act to nonspecifica
Externí odkaz:
https://doaj.org/article/bc1456c5e68640488a5ed89db7907bd5
Publikováno v:
International Journal of Cell Biology, Vol 2011 (2011)
The ETS family transcription factor PU.1 is a key regulator of haematopoietic differentiation. Its expression is dynamically controlled throughout haematopoiesis in order to direct appropriate lineage specification. Elucidating the biological role of
Externí odkaz:
https://doaj.org/article/8efa5967ac1d4078bc28579982e9904e
Autor:
Alister P. W. Funnell, Laura J. Norton, Samantha Hallal, Richard C. M. Pearson, Kate G. R. Quinlan, Merlin Crossley, Elizabeth S. Stout
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Scientific Reports
Scientific Reports
The Krüppel-like factor (KLF) family of transcription factors play critical roles in haematopoiesis. KLF1, the founding member of the family, has been implicated in the control of both erythropoiesis and megakaryopoiesis. Here we describe a novel sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead39925b4bea4084acec9031c533464
https://doaj.org/article/a37d4ae2beb44fd8a42326855e39b724
https://doaj.org/article/a37d4ae2beb44fd8a42326855e39b724
Autor:
Merlin Crossley, Richard C. M. Pearson, Alexander J. Knights, Thomas J. Gonda, Crisbel M. Artuz, Kate G. R. Quinlan, Katya Ravid, Alister P. W. Funnell
Publikováno v:
Biotechnology Reports, Vol 20, Iss, Pp-(2018)
Biotechnology Reports
Biotechnology Reports
Highlights • GATA1 and FLI1 switch on the endogenous platelet factor 4 (Pf4) gene in fibroblasts. • Pf4 expression is maintained and increases over time. • PF4 protein is secreted and readily collected. • A new technology for the g0065neratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd9677d3e7f889a55bc5a1a1847fd6a
http://www.sciencedirect.com/science/article/pii/S2215017X18301668
http://www.sciencedirect.com/science/article/pii/S2215017X18301668
Publikováno v:
Inflammopharmacology. 29(2)
1. A strategy is described for evaluating drugs against different phases in the development of an auto allergic disease, experimental allergic encephalomyelitis. It is based on a cell transfer technique whereby the disease is passively transferred wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eaa392ba6de815a0f2a00fa658af8cdc
https://pubmed.ncbi.nlm.nih.gov/30778876
https://pubmed.ncbi.nlm.nih.gov/30778876
Autor:
Merlin Crossley, Wooi F. Lim, Richard C. M. Pearson, Alister P. W. Funnell, Jon Burdach, Kate G. R. Quinlan
Publikováno v:
Nucleic Acids Research
Transcription factors are often regarded as having two separable components: a DNA-binding domain (DBD) and a functional domain (FD), with the DBD thought to determine target gene recognition. While this holds true for DNA binding in vitro, it appear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7427542b663cc4d08e1987530a748128
https://doi.org/10.1093/nar/gkv1380
https://doi.org/10.1093/nar/gkv1380