Zobrazeno 1 - 10
of 345
pro vyhledávání: '"C M, Metzler"'
Autor:
C. M. Metzler, Robert Shumaker
Publikováno v:
Drug Information Journal. 32:1063-1072
Proposals are being made for changes in bioequivalence criteria, the so-called ‘population’ and ‘individual’ bioequivalence methodologies. The proposed criteria require assumptions that have not yet been validated, including the equality of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e80103266cf3a558758a6a882acab90
https://doi.org/10.1177/009286159803200426
https://doi.org/10.1177/009286159803200426
Publikováno v:
Annals of the New York Academy of Sciences. 721:168-177
The characterization is reported of two peptide fragments (SBD106 and SBD122) containing the starch-binding domain (SBD) of Aspergillus sp. glucoamylase I. The starch-binding peptides were produced in Escherichia coli as fusion proteins of the maltos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e9b570438fcedc1a956d807cdd45a0d
https://doi.org/10.1111/j.1749-6632.1994.tb47390.x
https://doi.org/10.1111/j.1749-6632.1994.tb47390.x
Autor:
D E, Metzler, C M, Metzler, E T, Mollova, R D, Scott, S, Tanase, K, Kogo, T, Higaki, Y, Morino
Publikováno v:
The Journal of biological chemistry. 269(45)
Continuing a previous investigation (Kintanar, A., Metzler, C. M., Metzler, D. E., and Scott, R. D. (1991) J. Biol. Chem. 266, 17222-17229), we have recorded 1H NMR spectra at 500 MHz in the 10-18-ppm range for the 93-kDa porcine cytosolic aspartate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6a2b73d31d383564199b010c813d24f3
https://pubmed.ncbi.nlm.nih.gov/7961736
https://pubmed.ncbi.nlm.nih.gov/7961736
Publikováno v:
The Journal of biological chemistry. 272(28)
Two high resolution crystal structures of cytosolic aspartate aminotransferase from pig heart provide additional insights into the stereochemical mechanism for ligand-induced conformational changes in this enzyme. Structures of the homodimeric native
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dc2dddcab3ee96845fd68df66050ad25
https://pubmed.ncbi.nlm.nih.gov/9211866
https://pubmed.ncbi.nlm.nih.gov/9211866
Autor:
D E, Metzler, C M, Metzler, R D, Scott, E T, Mollova, H, Kagamiyama, T, Yano, S, Kuramitsu, H, Hayashi, K, Hirotsu, I, Miyahara
Publikováno v:
The Journal of biological chemistry. 269(45)
We have recorded 500-MHz 1H NMR spectra in the 10-18-ppm range for aspartate aminotransferase from Escherichia coli and for three specific mutant forms. Histidine 143 has been replaced by either alanine or asparagine. In the third mutant, tryptophan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::362a241e36b1137651b9680bf3e89f4a
https://pubmed.ncbi.nlm.nih.gov/7961737
https://pubmed.ncbi.nlm.nih.gov/7961737
Publikováno v:
International journal of clinical pharmacology and therapeutics. 32(5)
The effects of nicorandil, a nicotinamide derived vasodilator combining nitrate and potassium channel opener actions, on kidney function have not been determined. This study investigated changes in renal blood flow and glomerular filtration rate as e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::67297d922bd86bd42dacd07a01afc8e2
https://pubmed.ncbi.nlm.nih.gov/7921519
https://pubmed.ncbi.nlm.nih.gov/7921519
Publikováno v:
The Journal of biological chemistry. 266(26)
Observation of the 93-kDa cytosolic aspartate aminotransferase by 500-MHz 1H NMR spectroscopy in H2O has revealed a series of resonances in the 10-18 ppm range arising from exchangeable protons. One of these (peak A) has been assigned to the proton b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d1f998c548ee9c588232078fba77f89c
https://pubmed.ncbi.nlm.nih.gov/1654326
https://pubmed.ncbi.nlm.nih.gov/1654326
Publikováno v:
The Journal of biological chemistry. 266(15)
Tryptophanase (tryptophan: indole-lyase) from Escherichia coli has been isolated in the holoenzyme form and its absorption spectra and acid-base chemistry have been reevaluated. Apoenzyme has been prepared by dialysis against sodium phosphate and L-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2927a2d3d5cf18c2b7c3427a0b9f88de
https://pubmed.ncbi.nlm.nih.gov/2033039
https://pubmed.ncbi.nlm.nih.gov/2033039
Publikováno v:
Veterinary and human toxicology. 32(4)
A 10-y history of high rates of perinatal deaths and congenital anomalies in dogs in a Shetland Sheepdog kennel prompted investigations into the cause(s). Skeletal fluorosis (mottled teeth in pups, bony exostoses in adults) followed use of a commerci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ff26920c3ebe568ab4c27f2d851cc8de
https://pubmed.ncbi.nlm.nih.gov/2389542
https://pubmed.ncbi.nlm.nih.gov/2389542
Publikováno v:
Clinical therapeutics. 12(3)
Local and systemic tolerance and drug pharmacokinetics were evaluated after a single intravenous infusion of 75 to 1,000 mg of trospectomycin or placebo in 96 healthy volunteers. No clinically significant changes, trends, or abnormalities were observ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::12824b9b16ef34d710d204f6e91a73ef
https://pubmed.ncbi.nlm.nih.gov/2143104
https://pubmed.ncbi.nlm.nih.gov/2143104