Zobrazeno 1 - 4
of 4
pro vyhledávání: '"C M, Koboldt"'
Autor:
T. D. PENNING, S. W. KRAMER, L. F. LEE, P. W. COLLINS, C. M. KOBOLDT, K. SEIBERT, A. W. VEENHUIZEN, Y. Y. ZHANG, P. C. ISAKSON
Publikováno v:
ChemInform. 28
Autor:
Rita M. Huff, Yan Zhang, A. W. Veenhuizen, Jing Yuan, Karen Seibert, D.-C. Yang, Xiangdong Xu, C. M. Koboldt, P. W. Collins, Yi Yu, Richard Weier, J. N. Cogburn, Koszyk Francis, J. Masferrer, W. E. Perkins, Ish Kumar Khanna, Peter C. Isakson
Publikováno v:
Journal of medicinal chemistry. 43(16)
A series of heteroaryl modified 1,2-diarylimidazoles has been synthesized and found to be potent and highly selective (1000-9000-fold) inhibitors of the human COX-2. 3-Pyridyl derived COX-2 selective inhibitor (25) exhibited excellent activity in acu
Autor:
Q K, Huynh, H, Boddupalli, S A, Rouw, C M, Koboldt, T, Hall, C, Sommers, S D, Hauser, J L, Pierce, R G, Combs, B A, Reitz, J A, Diaz-Collier, R A, Weinberg, B L, Hood, B F, Kilpatrick, C S, Tripp
Publikováno v:
The Journal of biological chemistry. 275(34)
Nuclear factor kappa B (NF-kappaB) is a ubiquitous, inducible transcription factor that regulates the initiation and progression of immune and inflammatory stress responses. NF-kappaB activation depends on phosphorylation and degradation of its inhib
Autor:
J J, Talley, S R, Bertenshaw, D L, Brown, J S, Carter, M J, Graneto, C M, Koboldt, J L, Masferrer, B H, Norman, D J, Rogier, B S, Zwwifel, K, Seibert
Publikováno v:
Medicinal research reviews. 19(3)
A series of methysulfonyl or sulfonamido substituted 4,5-diaryloxazole were prepared and evaluated for their ability to inhibit the inducible form of cyclooxygenase (COX-2) in vitro and in vivo. Several unique substitution patterns were identified th