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Tbx2 Represses Expression of Connexin43 in Osteoblastic-like Cells

Autor: James L. Borke, Cecilia W. Lo, Jung Ren Chen, Margaret L. Kirby, C. M. Isales, Roni J. Bollag, Jack C. Yu, B. Chatterjee, R. Meyer

Publikováno v: Calcified Tissue International. 74:561-573

Tbx2 belongs to a family of developmental transcription regulatory factors. We evaluated whether the gap junction protein Connexin43 (Cx43), an important regulator of osteoblast function and bone development, may be a downstream target gene regulated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dcbbe98cbd81919aeb107c8c69b18b7
https://doi.org/10.1007/s00223-003-0106-5

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A midregion parathyroid hormone-related peptide mobilizes cytosolic calcium and stimulates formation of inositol trisphosphate in a squamous carcinoma cell line

Autor: C M Isales, M S Moyer, M Mitnick, A Behal, J Gasalla-Herraiz, Y Kats, John J. Orloff, M H Nathanson, Michael B. Ganz

Publikováno v: Endocrinology. 137:5376-5385

A midregion fragment of PTH-related protein (PTHrP), which is intensively conserved across species, has been identified as a secretory product of several different cell types, including keratinocytes and squamous carcinomas. As recent data suggest th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::490337e9f8dbeb61d3fd49dbb4002918
https://doi.org/10.1210/endo.137.12.8940360

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CART deficiency increases body weight but does not alter bone strength

Autor: S M, Bartell, C M, Isales, C A, Baile, M J, Kuhar, M W, Hamrick

Publikováno v: Journal of musculoskeletalneuronal interactions. 8(2)

The regulation of bone metabolism mediated by leptin is a complex process that is not clearly understood. Recent studies suggest that CART (cocaine-amphetamine related transcript) is a significant neuronal co-factor when combined with leptin. CART de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2710fd15b292eb22d9b4d4123768a115
https://pubmed.ncbi.nlm.nih.gov/18622083

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Osteoblast-derived cells express functional glucose-dependent insulinotropic peptide receptors

Autor: R J, Bollag, Q, Zhong, P, Phillips, L, Min, L, Zhong, R, Cameron, A L, Mulloy, H, Rasmussen, F, Qin, K H, Ding, C M, Isales

Publikováno v: Endocrinology. 141(3)

Glucose-dependent insulinotropic peptide (GIP) is a 42-amino acid peptide synthesized and secreted from endocrine cells in the small intestine. The role of GIP in coupling nutrient intake and insulin secretion, the incretin effect, is well known. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4fce681e60568deceea79a90dcef82c2
https://pubmed.ncbi.nlm.nih.gov/10698200

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Expression of inducible nitric oxide synthase in breast cancer correlates with metastatic disease

Autor: A, Dueñas-Gonzalez, C M, Isales, M, del Mar Abad-Hernandez, R, Gonzalez-Sarmiento, O, Sangueza, J, Rodriguez-Commes

Publikováno v: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 10(7)

Breast cancer is characterized by its ability to metastasize rapidly. Factors that might facilitate this metastatic potential include tumor vascularity. Nitric oxide (NO), a labile compound synthesized by NO synthase (NOS), is a major regulator not o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::769616a303d25ae3dae897e7e0f93253
https://pubmed.ncbi.nlm.nih.gov/9237172

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Atrial natriuretic peptide enhances activity of potassium conductance in adrenal glomerulosa cells

Autor: Michael B. Ganz, P. Q. Barrett, C. M. Isales, J. J. Nee

Publikováno v: The American journal of physiology. 266(5 Pt 1)

Aldosterone secretion from the adrenal glomerulosa (AG) cells is inhibited by atrial natriuretic peptide (ANP). Inasmuch as alterations in K+ conductance can modulate aldosterone secretion, the effect of ANP on intracellular K+ homeostasis was invest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c7faf805884d1f7c88bea14a9cb2fd1
https://pubmed.ncbi.nlm.nih.gov/7515565

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25-Hydroxyvitamin D, Insulin-Like Growth Factor-I, and Bone Mineral Accrual during Growth

Autor: M. E. Breen, E. M. Laing, D. B. Hall, D. B. Hausman, R. G. Taylor, C. M. Isales, K. H. Ding, N. K. Pollock, M. W. Hamrick, C. A. Baile, R. D. Lewis

Publikováno v: Endocrinology. 151:5974-5974

Context: The extent to which 25-hydroxyvitamin D [25(OH)D] and IGF-I influence bone mineral content (BMC) accrual from early to mid-puberty is unclear. Objective, Setting, and Participants: This study sought to determine relationships among 25(OH)D,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a9b62a229853a8ef69c4f63b58acc50
https://doi.org/10.1210/endo.151.12.9996

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Atrial natriuretic peptide differentially modulates T- and L-type calcium channels

Autor: W. B. Bollag, R. T. McCarthy, C. M. Isales, H. Rasmussen, P. Q. Barrett

Publikováno v: Scopus-Elsevier

Atrial natriuretic peptide (ANP) inhibits the secretion of aldosterone stimulated by any of these major physiological agonists: angiotensin II, adrenocorticotropic hormone, or K+. The stimulatory actions of each of these agonists depend on calcium in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4d697da0566dc5e6fc3763d167f9e5f
https://pubmed.ncbi.nlm.nih.gov/2156446

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