Výsledky vyhledávání - "C M, Ireland"

A new pregnane glycoside and a furostanol glycoside from Digitalis cariensis

Autor: H, Kirmizibekmez, D, Taşdemir, T, Ersöz, C M, Ireland, I, Caliş

Publikováno v: Die Pharmazie. 57(10)

Chemical investigation of the aerial parts of Digitalis cariensis Boiss. ex Jaub.Spach resulted in the isolation of a new pregnane glycoside, cariensisoside (1) and a furostanol glycoside, uttroside A (2), along with the two known phenylethanoid glyc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::850b07fae192f3e4fe9334f665388197
https://pubmed.ncbi.nlm.nih.gov/12426957

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6-Methoxy-7-methyl-8-oxoguanine, an unusual purine from the ascidian Symplegma rubra

Autor: C. M. Ireland, R. M. Da Rocha, A. M. P. Almeida, R. G. S. Berlinck, C. J. Smith, B. S. Lindsay

Publikováno v: Journal of natural products. 62(11)

A new purine derivative, 6-methoxy-7-methyl-8-oxoguanine (1), along with 8-oxoadenine (2) and the human metabolite 3-methylxanthine (3), has been isolated from the ascidian Symplegma rubra collected on the southeastern coastline of Brazil. The struct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1655aa98954ab49620454e68d932e3
https://pubmed.ncbi.nlm.nih.gov/10579878

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Establishment of an in vitro model for cisplatin resistance in human neuroblastoma cell lines

Autor: C M, Ireland, S M, Pittman, S L, Jones, P R, Harnett

Publikováno v: Anticancer research. 14(6B)

Two unique cisplatin-resistant neuroblastoma (NB) cell lines have been derived from the established lines IMR-32 and SK-N-SH by treatment with escalating doses of cisplatin. IMR/CP.20 was 6.6-fold and SK/CP.15 was 3.8-fold more resistant to the cytot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5dc1f144b63f138004225872d80ebf6c
https://pubmed.ncbi.nlm.nih.gov/7872659

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Makaluvamines, marine natural products, are active anti-cancer agents and DNA topo II inhibitors

Autor: L R, Barrows, D C, Radisky, B R, Copp, D S, Swaffar, R A, Kramer, R L, Warters, C M, Ireland

Publikováno v: Anti-cancer drug design. 8(5)

The makaluvamines were isolated from a sponge of the genus Zyzzya by following bioactivity against the human colon carcinoma cell line, HCT 116. These compounds have considerable cytotoxic activity. The makaluvamines appear to be acting through inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1ac8020104684d725a6cdf058627845d
https://pubmed.ncbi.nlm.nih.gov/8251041

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Analysis of N-ras gene mutations in acute myeloid leukemia by allele specific restriction analysis

Autor: Henry M. Kronenberg, A. V. Todd, C. M. Ireland, Harry J. Iland, T. J. Radloff

Publikováno v: American journal of hematology. 38(3)

N-ras gene activation occurs via single base substitutions in codons 12, 13, and 61. We have developed a rapid screening method, termed allele specific restriction analysis (ASRA), for detection of N-ras mutations at these three critical codons in ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b278524fe27557ecfb5a645a5a35c45d
https://pubmed.ncbi.nlm.nih.gov/1951319

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Allele-specific enrichment: a method for the detection of low level N-ras gene mutations in acute myeloid leukemia

Autor: A V, Todd, C M, Ireland, H J, Iland

Publikováno v: Leukemia. 5(2)

Point mutations involving codons 12, 13, and 61 of the N-ras gene are found in patients with acute myeloid leukemia (AML). We have developed a sensitive assay for the analysis of these mutations which we have called allele-specific enrichment. In thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::458a1676549c3e1a043338ce86b8cbc5
https://pubmed.ncbi.nlm.nih.gov/2020198

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Detection of N-ras Mutations in Acute Myeloid Leukemia

Autor: A. V. Todd, Harry J. Iland, S. Yi, C. M. Ireland

Publikováno v: The Superfamily of ras-Related Genes ISBN: 9781468460209

N-ras gene activation due to single base substitutions has been found in 20–40% of patients with acute myeloid leukemia (AML) depending on the technique used. Differential hybridization to allele specific oligonucleotide (ASO) probes detects mutati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f8eb3c3ab87ae66ad843bd08fdb8ae16
https://doi.org/10.1007/978-1-4684-6018-6_22

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Comparative interactions of streptozotocin and chlorozotocin with DNA of an insulin-secreting cell line (RINr)

Autor: C. M. Ireland, Brooke T. Mossman, M. Filipak, S. LeDoux, G. L. Wilso

Publikováno v: Diabetologia. 29:186-191

Both streptozotocin and chlorozotocin, the 2-chloroethyl analogue of streptozotocin, are diabetogenic chemicals in rodents. Although these chemicals are similar structurally, they appear to act on pancreatic B cells via different mechanisms. In studi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9bc3be4eb1bfedbec40649768970c21
https://doi.org/10.1007/bf02427091

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