Výsledky vyhledávání - "C M, Hackeng"

Postoperative myocardial injury and platelet reactivity in patients undergoing vascular surgery

Autor: K L, Zheng, W L, Bor, L M, Vernooij, N C, Breet, J C, Kelder, C M, Hackeng, R H J, Kropman, J M, Ten Berg, P G, Noordzij

Publikováno v: Thrombosis Research, 218, 177-185. Elsevier Science

BACKGROUND: Postoperative myocardial injury (PMI) after major vascular surgery, detected by elevated cardiac troponin (cTn), has been associated with morbidity and mortality. It is unclear whether the pathophysiology of PMI is determined by increased

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ac26d98f0e049c47539fa572921395a
https://cris.maastrichtuniversity.nl/en/publications/be22804c-3d9f-4ffb-8149-00dcafc2e88c

Zobrazit plný text záznamu

High versus standard clopidogrel loading in patients undergoing carotid artery stenting prior to cardiac surgery to assess the number of microemboli detected with transcranial Doppler: results of the randomized IMPACT trial

Autor: J, Van Der Heyden, J, Van Werkum, C M, Hackeng, J C, Kelder, N J, Breet, V H M, Deneer, R G A, Ackerstaff, S C, Tromp, J P P M, De Vries, J A, Vos, M J, Suttorp, E H A, Elsenberg, D, Van Neerven, W J, Schonewille, F, Wolters, J M, Ten Berg

Publikováno v: The Journal of cardiovascular surgery. 54(3)

The aim of this study was to compare the effects of 300 mg or 600 mg clopidogrel loading dose, prior to carotid artery stenting (CAS) on the number of transcranial Doppler (TCD)-detected microembolic signals (MES) and to investigate the relationship

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::02203ed3612e18806e3940a83670ead5
https://pubmed.ncbi.nlm.nih.gov/23138609

Zobrazit plný text záznamu

Low-density lipoprotein activates the small GTPases Rap1 and Ral in human platelets

Autor: C M, Hackeng, B, Franke, I A, Relou, G, Gorter, J L, Bos, H J, van Rijn, J W, Akkerman

Publikováno v: The Biochemical journal. 349(Pt 1)

Physiological concentrations of low-density lipoprotein (LDL) sensitize blood platelets to alpha-thrombin- and collagen-induced secretion, and after prolonged contact trigger secretion independent of other agonists. Here we report that LDL activates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::207f4e69ed96b55f60e23072faf4e079
https://pubmed.ncbi.nlm.nih.gov/10861233

Zobrazit plný text záznamu

Early platelet activation by low density lipoprotein via p38MAP kinase

Autor: C M, Hackeng, I A, Relou, M W, Pladet, G, Gorter, H J, van Rijn, J W, Akkerman

Publikováno v: Thrombosis and haemostasis. 82(6)

Low Density Lipoprotein (LDL) is known to sensitize platelets for physiological agonists. To clarify the basis of this sensitization, we investigated the involvement of p38MAP Kinase (p38MAPK). As dual phosphorylation on Thr180 and Tyr182 of p38MAPK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::24f8281c5ae4b954304615f97d37ea00
https://pubmed.ncbi.nlm.nih.gov/10613665

Zobrazit plný text záznamu