Zobrazeno 1 - 10
of 15
pro vyhledávání: '"C M, Ewing"'
Autor:
S, Zha, W R, Gage, J, Sauvageot, E A, Saria, M J, Putzi, C M, Ewing, D A, Faith, W G, Nelson, A M, De Marzo, W B, Isaacs
Publikováno v:
Cancer research. 61(24)
Cyclooxygenase-2 (COX-2) is the inducible isoform of the rate-limiting enzymes that convert arachidonic acid to proinflammatory prostaglandins as well as a primary target for nonsteroidal anti-inflammatory drugs. Accumulating evidence suggests that u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6aa1fae976e35c1395bddbb9693a805b
https://pubmed.ncbi.nlm.nih.gov/11751373
https://pubmed.ncbi.nlm.nih.gov/11751373
Publikováno v:
Cancer research. 61(16)
Research into molecular and genetic mechanisms underlying familial prostate cancer would be greatly advanced by in vitro models of prostate tumor cells representing primary tumors. We have successfully established an immortalized human prostate epith
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b2aa52e7f18271e74717149df4151d40
https://pubmed.ncbi.nlm.nih.gov/11507036
https://pubmed.ncbi.nlm.nih.gov/11507036
Autor:
J, Luo, D J, Duggan, Y, Chen, J, Sauvageot, C M, Ewing, M L, Bittner, J M, Trent, W B, Isaacs
Publikováno v:
Cancer research. 61(12)
Critical aspects of the biology and molecular basis for prostate malignancy remain poorly understood. To reveal fundamental differences between benign and malignant growth of prostate cells, we performed gene expression profiling of primary human pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a60d7fd5fbd52c19e09a134fdc168a96
https://pubmed.ncbi.nlm.nih.gov/11406537
https://pubmed.ncbi.nlm.nih.gov/11406537
Publikováno v:
The Prostate. 45(4)
E-cadherin and alpha-catenin are components of adherens junctions which mediate calcium-dependent, cell-cell adhesion in a homotypic manner. Both these molecules have been defined as useful tumor markers as their altered expression correlates with in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b3ac7c087330d3aa3ec2f1c7f2dc0e82
https://pubmed.ncbi.nlm.nih.gov/11102958
https://pubmed.ncbi.nlm.nih.gov/11102958
Publikováno v:
Cancer research. 57(13)
Cadherins are a family of calcium-dependent, cell-cell adhesion molecules that play an important morphoregulatory role in a wide variety of tissues. Alterations in cadherin function have been implicated in tumor progression in a number of adenocarcin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::32e936bb2600809cf162dcb6addecea7
https://pubmed.ncbi.nlm.nih.gov/9205085
https://pubmed.ncbi.nlm.nih.gov/9205085
Autor:
J D, Brooks, G S, Bova, C M, Ewing, S, Piantadosi, B S, Carter, J C, Robinson, J I, Epstein, W B, Isaacs
Publikováno v:
Cancer research. 56(16)
Inactivation of the p53 gene has been implicated in prostate cancer progression. To determine the role of p53 inactivation in the progression of clinical prostatic carcinomas, we assessed 67 tumors derived from patients with clinically localized dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::403daa7713be89b759bc98ce39efca42
https://pubmed.ncbi.nlm.nih.gov/8706029
https://pubmed.ncbi.nlm.nih.gov/8706029
Autor:
C M, Ewing, N, Ru, R A, Morton, J C, Robinson, M J, Wheelock, K R, Johnson, J C, Barrett, W B, Isaacs
Publikováno v:
Cancer research. 55(21)
Considerable evidence now exists to support an important role for the E-cadherin-mediated cell-cell adhesion pathway as a suppressor of the invasive phenotype in adenocarcinoma cells. Previous studies have found that this pathway is frequently aberra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::52dd9972671a2f50ec7a8ff65b1ba707
https://pubmed.ncbi.nlm.nih.gov/7585512
https://pubmed.ncbi.nlm.nih.gov/7585512
Publikováno v:
Cancer surveys. 23
A number of genetic changes have been documented in prostate cancer, ranging from allelic loss to point mutations and changes in DNA methylation patterns (summarized in Fig. 1). The most consistent changes seen are those of allelic loss events, with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9d5e89ad4b5badb08b4e8fe6f2dade63
https://pubmed.ncbi.nlm.nih.gov/7621457
https://pubmed.ncbi.nlm.nih.gov/7621457
Publikováno v:
Seminars in oncology. 21(5)
A number of genetic changes have been documented in prostate cancer, ranging from allelic loss to point mutations and changes in DNA methylation patterns (summarized in Fig 1). To date, the most consistent changes are those of allelic loss events, wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cb61dd696388f943734f9aeed46bd25f
https://pubmed.ncbi.nlm.nih.gov/7939745
https://pubmed.ncbi.nlm.nih.gov/7939745
Reduction of E-cadherin levels and deletion of the alpha-catenin gene in human prostate cancer cells
Publikováno v:
Cancer research. 53(15)
The cadherins are a family of transmembrane glycoproteins responsible for calcium-dependent cell-cell adhesion. This adhesion is mediated by a group of cytoplasmic proteins, the catenins, which act inside the cell to couple the cadherin molecule to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0a398528a6d2f0ecde0330a03c375f2d
https://pubmed.ncbi.nlm.nih.gov/8339265
https://pubmed.ncbi.nlm.nih.gov/8339265