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Structure of the human gamma-fibrinogen gene. Alternate mRNA splicing near the 3' end of the gene produces gamma A and gamma B forms of gamma-fibrinogen

Autor: David E. Cummings, Jeffrey A. Kant, Gerald R. Crabtree, Albert J. Fornace, C M Comeau

Publikováno v: Journal of Biological Chemistry. 259:12826-12830

The gamma chain of human fibrinogen exists in 2 nonallelic forms, gamma A and gamma B, which differ only in their carboxyl termini. We have found that only one genomic locus exists for gamma-fibrinogen and that the gamma A and gamma B chains arise by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::249ca468dd3e3f12777d98a0777bc79b
https://doi.org/10.1016/s0021-9258(18)90821-5

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Evolution and structure of the fibrinogen genes. Random insertion of introns or selective loss?

Autor: G R, Crabtree, C M, Comeau, D M, Fowlkes, A J, Fornace, J D, Malley, J A, Kant

Publikováno v: Journal of molecular biology. 185(1)

Chromosomal linkage as well as sequence homologies provide unequivocal evidence that the genes for the alpha, beta and gamma chains of fibrinogen arose by successive duplication of a single ancestral gene. Yet, when the three fibrinogen chains are al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ce6ab8d4d8c47feea9d16e6e1282ecf5
https://pubmed.ncbi.nlm.nih.gov/4046033

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