Zobrazeno 1 - 10
of 1 121
pro vyhledávání: '"C Luca"'
Autor:
Gregory Foran, Ryan Douglas Hallam, Marvel Megaly, Anel Turgambayeva, Daniel Antfolk, Yifeng Li, Vincent C. Luca, Aleksandar Necakov
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-24 (2024)
Abstract The Notch receptor is a pleiotropic signaling protein that translates intercellular ligand interactions into changes in gene expression via the nuclear localization of the Notch intracellular Domain (NICD). Using a combination of immunohisto
Externí odkaz:
https://doaj.org/article/6d4d0b894b754364b151eb9c1ceaea6b
Autor:
Qianqian Ming, Daniel Antfolk, David A. Price, Anna Manturova, Elliot Medina, Srishti Singh, Charlotte Mason, Timothy H. Tran, Keiran S. M. Smalley, Daisy W. Leung, Vincent C. Luca
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract The immune checkpoint protein, Lymphocyte activation gene-3 (LAG3), binds Major Histocompatibility Complex Class II (MHC-II) and suppresses T cell activation. Despite the recent FDA approval of a LAG3 inhibitor for the treatment of melanoma,
Externí odkaz:
https://doaj.org/article/7b12d9f7a4494fceb98b9a25a6dc0b12
Autor:
Ioanna Smyrlaki, Ferenc Fördős, Iris Rocamonde-Lago, Yang Wang, Boxuan Shen, Antonio Lentini, Vincent C. Luca, Björn Reinius, Ana I. Teixeira, Björn Högberg
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The Notch signaling pathway has fundamental roles in embryonic development and in the nervous system. The current model of receptor activation involves initiation via a force-induced conformational change. Here, we define conditions that rev
Externí odkaz:
https://doaj.org/article/e0cd4cdde23c495385b0467afe5fe727
Autor:
H. SĂRĂNDAN, ANA PIVODĂ, D. DRÎNCEANU, ANA SAUER, OLGA RADA, LILIANA CĂRPINIŞAN, CLAUDIA SALA, S. VOIA, C. LUCA
Publikováno v:
Scientific Papers Animal Science and Biotechnologies, Vol 42, Iss 1, Pp 267-267 (2023)
In the extraction process of the vegetable soy oils and sun-flower oils results in large quantities a waste that contains approximately 45% fat from which 58% is lecithin. This waste called “dreg” creates problems of environment pollution because
Externí odkaz:
https://doaj.org/article/70823be090734fd5a5cf6e5bc6fc66d8
Autor:
J. Sebastian Marquez, S. M. Shafiul Hasan, Masudur R. Siddiquee, Corneliu C. Luca, Virendra R. Mishra, Zoltan Mari, Ou Bai
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/c03932da885c4f56b106fe4483e3cf31
Autor:
Daniel K. Lester, Chase Burton, Alycia Gardner, Patrick Innamarato, Krithika Kodumudi, Qian Liu, Emma Adhikari, Qianqian Ming, Daniel B. Williamson, Dennie T. Frederick, Tatyana Sharova, Michael G. White, Joseph Markowitz, Biwei Cao, Jonathan Nguyen, Joseph Johnson, Matthew Beatty, Andrea Mockabee-Macias, Matthew Mercurio, Gregory Watson, Pei-Ling Chen, Susan McCarthy, Carlos MoranSegura, Jane Messina, Kerry L. Thomas, Lancia Darville, Victoria Izumi, John M. Koomen, Shari A. Pilon-Thomas, Brian Ruffell, Vincent C. Luca, Robert S. Haltiwanger, Xuefeng Wang, Jennifer A. Wargo, Genevieve M. Boland, Eric K. Lau
Publikováno v:
Nature Cancer. 4:222-239
Despite reports of striking outcomes, immunotherapy efficacy in melanoma is limited to subsets of patients 1, 2. Combining immunotherapies with other modalities has yielded limited improvements but also adverse events requiring cessation of treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a64da195ce606f3ff385fc17153f645
https://doi.org/10.1038/s43018-022-00506-7
https://doi.org/10.1038/s43018-022-00506-7
Autor:
J. Sebastian Marquez, S. M. Shafiul Hasan, Masudur R. Siddiquee, Corneliu C. Luca, Virendra R. Mishra, Zoltan Mari, Ou Bai
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Freezing of gait (FoG) is a disabling symptom characterized as a brief inability to step or by short steps, which occurs when initiating gait or while turning, affecting over half the population with advanced Parkinson's disease (PD). Several non-com
Externí odkaz:
https://doaj.org/article/f3f0a33e601141e08069fb79ab5e126f
Autor:
Karen Nuytemans, Farid Rajabli, Parker L. Bussies, Katrina Celis, William K. Scott, Carlos Singer, Corneliu C. Luca, Angel Vinuela, Margaret A. Pericak-Vance, Jeff M. Vance
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Background: The Latino population is greatly understudied in biomedical research, including genetics. Very little information is available on presence of known variants originally identified in non-Hispanic white patients or novel variants in the Lat
Externí odkaz:
https://doaj.org/article/4a5e96bdf8804ab8adcc05012adbfeeb
Autor:
David Gonzalez-Perez, Satyajit Das, Daniel Antfolk, Hadia S. Ahsan, Elliot Medina, Carolyn E. Dundes, Rayyan T. Jokhai, Emily D. Egan, Stephen C. Blacklow, Kyle M. Loh, Paulo C. Rodriguez, Vincent C. Luca
Publikováno v:
Nature Chemical Biology. 19:9-17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::283c38fb80538161d1d835995b238ede
https://doi.org/10.1038/s41589-022-01113-4
https://doi.org/10.1038/s41589-022-01113-4
Autor:
Vaccari, Erika d. l. R. M. Cabrera Ranaldi, Karen Nuytemans, Anisley Martinez, Corneliu C. Luca, Robert W. Keane, Juan Pablo de Rivero
Publikováno v:
Pharmaceuticals; Volume 16; Issue 6; Pages: 883
Parkinson’s disease (PD) is a neurodegenerative disorder marked by the death of dopaminergic neurons in the midbrain, the accumulation of α-synuclein aggregates, and motor deficits. A major contributor to dopaminergic neuronal loss is neuroinflamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::dfdfb8575583e5fed560b2fedcede68b