LivestockPlus — The sustainable intensification of forage-based agricultural systems to improve livelihoods and ecosystem services in the tropics

Autor: I. Rao, M. Peters, A. Castro, R. Schultze-Kraft, D. White, M. Fisher, J. Miles, C. Lascano, M. Blümmel, D. Bungenstab, J. Tapasco, G. Hyman, A. Bolliger, B. Paul, R. van der Hoek, B. Maass, T. Tiemann, M. Cuchillo, S. Douxchamps, C. Villanueva, A. Rincón, M. Ayarza, T. Rosenstock, G. Subbarao, J. Arango, J. Cardoso, M. Worthington, N. Chirinda, A. Notenbaert, A. Jenet, A. Schmidt, N. Vivas, R. Lefroy, K. Fahrney, E. Guimarães, J. Tohme, S. Cook, M. Herrero, M. Chacón, T. Searchinger, T. Rudel

Publikováno v: Tropical Grasslands-Forrajes Tropicales, Vol 3, Iss 2, Pp 59-82 (2015)

As global demand for livestock products (such as meat, milk and eggs) is expected to double by 2050, necessary increases to future production must be reconciled with negative environmental impacts that livestock cause. This paper describes the Livest

Externí odkaz: https://doaj.org/article/3aa22c330ddd4ff1a6a01b8e1760b438

Determinants of Ca2+ release restitution: Insights from genetically altered animals and mathematical modeling

Autor: Carlos Alfredo Valverde, Evangelia G. Kranias, Leandro A. Diaz-Zegarra, Jorge A. Negroni, Juan Ignacio Felice, Ernesto A. Aiello, Marilén Federico, Elena C. Lascano, Alejandra Cely-Ortiz, Alicia Mattiazzi, Julieta Palomeque, Xander H.T. Wehrens

Publikováno v: The Journal of General Physiology
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

The present work shows that SR Ca2+ load and RYR2 Ca2+ sensitivity are major determinants of Ca2+ release restitution (CRR) after each heartbeat. Mathematical modeling led us to speculate that the velocity of SR Ca2+ refilling might regulate CRR inde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::badfe85072de9cb42229aa1660c69f52
https://doi.org/10.1085/jgp.201912512

Augmentation Index in an Animal Model of Myocardial Ischemia-Reperfusion and Heart Failure: a Preliminary Report

Autor: Edmundo I. Cabrera Fischer, A. F. Pascaner, J. A. Negroni, Elena C. Lascano, Sandra Wray

Publikováno v: 2019 Global Medical Engineering Physics Exchanges/ Pan American Health Care Exchanges (GMEPE/PAHCE).

Cardiovascular indices are useful to evaluate myocardial damage and the effectiveness of medical interventions during ischemic heart failure. Left ventricular thickening has been used to evaluate myocardial ischemia generated by transitory induced co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e83cb439ee26a3d885372719164f07b
https://doi.org/10.1109/gmepe-pahce.2019.8717339

Phospholamban ablation rescues the enhanced propensity to arrhythmias of mice with CaMKII-constitutive phosphorylation of RyR2 at site S2814

Autor: Julieta Palomeque, Gabriela Mazzocchi, Evangelia G. Kranias, Alicia Mattiazzi, D. Fainstein, Darlene G. Skapura, Xander H.T. Wehrens, Mark McCauley, P. N. González, Leandro Matías Sommese, Jorge A. Negroni, P. Contreras, M. N. Di Carlo, Juan Ignacio Felice, Elena C. Lascano, Carlos Alfredo Valverde

Publikováno v: The Journal of Physiology. 594:3005-3030

Key points Mice with Ca(2+) -calmodulin-dependent protein kinase (CaMKII) constitutive pseudo-phosphorylation of the ryanodine receptor RyR2 at Ser2814 (S2814D(+/+) mice) exhibit a higher open probability of RyR2, higher sarcoplasmic reticulum (SR) C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::746763441678051258a337b9ff0be179
https://doi.org/10.1113/jp271622

β-adrenergic effects on cardiac myofilaments and contraction in an integrated rabbit ventricular myocyte model

Autor: Eleonora Grandi, Aldrin V. Gomes, Jose L. Puglisi, Jorge A. Negroni, Stefano Morotti, Elena C. Lascano, Donald M. Bers

Publikováno v: Negroni, JA; Morotti, S; Lascano, EC; Gomes, AV; Grandi, E; Puglisi, JL; et al.(2015). β-adrenergic effects on cardiac myofilaments and contraction in an integrated rabbit ventricular myocyte model. Journal of Molecular and Cellular Cardiology, 81, 162-175. doi: 10.1016/j.yjmcc.2015.02.014. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/0g82v46v

A five-state model of myofilament contraction was integrated into a well-established rabbit ventricular myocyte model of ion channels, Ca(2+) transporters and kinase signaling to analyze the relative contribution of different phosphorylation targets

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2ee213d22ce7e9a2c6ca48cf58dd4c
https://doi.org/10.1016/j.yjmcc.2015.02.014