Zobrazeno 1 - 10
of 3 050
pro vyhledávání: '"C Larson"'
Autor:
Annapoorna Venkatachalam, Cristina Correia, Kevin L. Peterson, Xianon Hou, Paula A. Schneider, Annabella R. Strathman, Karen S. Flatten, Chance C. Sine, Emily A. Balczewski, Cordelia D. McGehee, Melissa C. Larson, Laura N. Duffield, X. Wei Meng, Nicole D. Vincelette, Husheng Ding, Ann L. Oberg, Fergus J. Couch, Elizabeth M. Swisher, Hu Li, S. John Weroha, Scott H. Kaufmann
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-16 (2024)
Abstract Recent studies indicate that replication checkpoint modulators (RCMs) such as inhibitors of CHK1, ATR, and WEE1 have promising monotherapy activity in solid tumors, including platinum-resistant high grade serous ovarian cancer (HGSOC). Howev
Externí odkaz:
https://doaj.org/article/10416db1db3e4dd388e15b58bcaf44a8
Autor:
M Wiens, PharmD, E Kumbakumba, MBChB, M Ansermino, MBBCh, N Kissoon, MD, J Singer, PhD, H Wong, PhD, A Ndamira, MBChB, J Kabakyenga, PhD, J Kiwanuka, MBChB, G Zhou, MSc, C Larson
Publikováno v:
The Lancet Global Health, Vol 3, Iss S1, p S31 (2015)
Background: Acute infectious diseases are an important contributor to under-5 mortality. Mortality following discharge is an important but poorly recognised contributor to overall mortality. The identification of at-risk children is critical in devel
Externí odkaz:
https://doaj.org/article/230e40121e2f4c7e9b6bdd7f0c86b67f
Publikováno v:
Cancer Medicine, Vol 13, Iss 10, Pp n/a-n/a (2024)
Abstract Although the development of immunotherapies has been revolutionary in the treatment of several cancers, many cancer types remain unresponsive to immune‐based treatment and are largely managed by chemotherapy drugs. However, chemotherapeuti
Externí odkaz:
https://doaj.org/article/9c9066b8b51848d3a0b76e5ab96a9a54
Autor:
Kelley C. Larson, Lauren H. Martens, Michael Marconi, Christopher Dejesus, Suzanne Bruhn, Thomas A. Miller, Barbara Tate, Jonathan M. Levenson
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-22 (2024)
Abstract Neuroinflammation is a key driver of neurodegenerative disease, however the tools available to model this disease biology at the systems level are lacking. We describe a translational drug discovery platform based on organotypic culture of m
Externí odkaz:
https://doaj.org/article/f99fd718d187495393c0c52cd3dd9f64
Autor:
Azucena Ramos, Catherine E. Koch, Yunpeng Liu-Lupo, Riley D. Hellinger, Taeyoon Kyung, Keene L. Abbott, Julia Fröse, Daniel Goulet, Khloe S. Gordon, Keith P. Eidell, Paul Leclerc, Charles A. Whittaker, Rebecca C. Larson, Audrey J. Muscato, Kathleen B. Yates, Juan Dubrot, John G. Doench, Aviv Regev, Matthew G. Vander Heiden, Marcela V. Maus, Robert T. Manguso, Michael E. Birnbaum, Michael T. Hemann
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract CAR-T therapy is a promising, novel treatment modality for B-cell malignancies and yet many patients relapse through a variety of means, including loss of CAR-T cells and antigen escape. To investigate leukemia-intrinsic CAR-T resistance mec
Externí odkaz:
https://doaj.org/article/6711e44bcbe14aeaa34f0e56893dd8c0
Autor:
Rebecca C. Larson, Michael C. Kann, Charlotte Graham, Christopher W. Mount, Ana P. Castano, Won-Ho Lee, Amanda A. Bouffard, Hana N. Takei, Antonio J. Almazan, Irene Scarfó, Trisha R. Berger, Andrea Schmidts, Matthew J. Frigault, Kathleen M. E. Gallagher, Marcela V. Maus
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Chimeric Antigen Receptor (CAR) T cells directed to B cell maturation antigen (BCMA) mediate profound responses in patients with multiple myeloma, but most patients do not achieve long-term complete remissions. In addition, recent evidence s
Externí odkaz:
https://doaj.org/article/008a498ec868469ca7437a0db7630ab9
Autor:
Allison M. Bock, Jennifer J. Gile, Melissa C. Larson, Kittika Poonsombudlert, Reema K. Tawfiq, Seth Maliske, Matthew J. Maurer, Brian F. Kabat, Jonas Paludo, David J. Inwards, Sabarish Ayyappan, Brian K. Link, Stephen M. Ansell, Thomas M. Habermann, Thomas E. Witzig, Grzegorz S. Nowakowski, James R. Cerhan, Umar Farooq, Yucai Wang
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Over the last two decades, the frontline therapy for mantle cell lymphoma (MCL) has evolved. However, the impact of subsequent lines of therapy on survival outcomes has not been well characterized. In this study, we investigated the treatmen
Externí odkaz:
https://doaj.org/article/ab1b048610ec4f4e949d375e8ba8630b
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 5, Pp 757-764 (2023)
Abstract Objective To report multiple cause of death (MCOD) occurrence among patients in the United States with amyotrophic lateral sclerosis (ALS). Methods Using death certificate data for all ALS deaths from 50 U.S. states and the District of Colum
Externí odkaz:
https://doaj.org/article/4746471400f243d49f091e2fae896a99
Autor:
Matthew J. Maurer, Carla Casulo, Melissa C. Larson, Thomas M. Habermann, Izidore S. Lossos, Yucai Wang, Loretta J. Nastoupil, Christopher Strouse, Dai Chihara, Peter Martin, Jonathon B. Cohen, Brad S. Kahl, W Richard Burack, Jean L. Koff, Yong Mun, Anthony Masaquel, Mei Wu, Michael C. Wei, Ashwini Shewade, Jia Li, James R. Cerhan, Brian K. Link, Christopher R. Flowers
Publikováno v:
Haematologica, Vol 999, Iss 1 (2023)
Mosunetuzumab is a novel bispecific antibody targeting epitopes on CD3 on T cells and CD20 on B cells with the goal of inducing T-cell mediated elimination of malignant B cells. A recent pivotal phase I/II clinical trial (GO29781) demonstrated that m
Externí odkaz:
https://doaj.org/article/1d7e46afb331468e9c6f00cad9ff0929
Autor:
Alaina C. Larson, Shelby M. Knoche, Gabrielle L. Brumfield, Kenadie R. Doty, Benjamin D. Gephart, Promise R. Moore-Saufley, Joyce C. Solheim
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 6, p 3211 (2024)
Pancreatic cancer is a lethal disease, harboring a five-year overall survival rate of only 13%. Current treatment approaches thus require modulation, with attention shifting towards liberating the stalled efficacy of immunotherapies. Select chemother
Externí odkaz:
https://doaj.org/article/d00158240d6d400fa1302c522a49c7b5