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THU0002 SOLVING THE COMPLEX MHC ASSOCIATIONS IN SLE IDENTIFIES SEX-RELATED GENE EFFECTS

Autor: B. Handsaker, Timothy J. Vyse, Nolan Kamitaki, David L. Morris, C. Langefeld, Steven A. McCarroll, Lindsey A. Criswell, R. R. Graham

Publikováno v: Annals of the Rheumatic Diseases. 79:213.1-214

Background:Genome-wide association analyses reveal that the Major Histocompatibility Complex (MHC) is the site of the strongest association signals in SLE and Sjögren’s syndrome. This associations in lupus and Sjögren’s syndrome are linked toHL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7142f5548e98659fe4b42e5dfd189e6
https://doi.org/10.1136/annrheumdis-2020-eular.2041

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Akademický článek

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X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndrome

Autor: Daniel J. Wallace, Wan-Fai Ng, Carrie A. Weaver, Maureen Rischmueller, Marie Wahren-Herlenius, Michael T. Brennan, Gideon M. Hirschfield, Christopher I. Amos, James Chodosh, Michael D. Rohrer, Susan D. Thompson, Katherine A. Siminovitch, Jeffrey C. Edberg, Torsten Witte, Timothy J. Vyse, Barbara M. Segal, Courtney G. Montgomery, Gunnel Nordmark, Valerie M. Harris, Jacen S. Maier-Moore, Judith A. James, Gabor G. Illei, Juan-Manuel Anaya, Tammy O. Utset, Lida Radfar, Ke Liu, Marta E. Alarcón-Riquelme, Diane L. Kamen, W. Joseph McCune, Roald Omdal, Pamela J. Hughes, Kristi A. Koelsch, Corinne Miceli-Richard, Patrick M. Gaffney, Vivian P. Bykerk, Per Eriksson, James A. Lessard, Edward C. Keystone, John B. Harley, Biji T. Kurien, Rajaram Gopalakrishnan, Jennifer A. Kelly, Robert P. Kimberly, Xianglan Lu, Adam Adler, Leah C. Kottyan, Erwin P. Bottinger, Graciela S. Alarcón, Betty P. Tsao, Sara Lazaro, Kenneth M. Kaufman, Joel M. Guthridge, Kathy L. Sivils, C. Langefeld, Michael H. Weisman, Diana H. Taft, Jay Kumar, Joan T. Merrill, R. Hal Scofield, Shibo Li, Nelson L. Rhodus, Xavier Mariette, Jacques-Eric Gottenberg, Gang Xie, Mitali Talsania, Ann Igoe, Christopher J. Lessard, Sarah L. Zimmerman, Bernardo A. Pons-Estel, Gary S. Gilkeson, Roland Jonsson, John A. Ice, Donald U. Stone, Deborah S. Cunninghame-Graham, Jane E. Salmon, Andrew J.W. Huang, David M Lewis, Astrid Rasmussen

Publikováno v: Arthritis & Rheumatology.

Objective More than 80% of autoimmune disease predominantly affects females, but the mechanism for this female bias is poorly understood. We suspected that an X chromosome dose effect accounts for this, and we undertook this study to test our hypothe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1129f40e81c4e2a76034c587e01da901
https://doi.org/10.1002/art.39560

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Admixture Mapping in Lupus Identifies Multiple Functional Variants within IFIH1 Associated with Apoptosis, Inflammation, and Autoantibody Production

Publikováno v: PLoS Genetics
PLoS Genetics, Vol 9, Iss 2, p e1003222 (2013)

Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease with a strong genetic component. African-Americans (AA) are at increased risk of SLE, but the genetic basis of this risk is largely unknown. To identify causal variants in SLE l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::330fb698a36aae3787f28de883e24c73
http://europepmc.org/articles/PMC3575474

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OP0121 Analysis of the MHC Region in a Large Cohort of Juvenile Idiopathic Arthritis Cases Identifies Independent Effects at HLA-DRB1 for the Most Common Subtypes of JIA

Publikováno v: Annals of the Rheumatic Diseases. 74:114.1-114

Background Juvenile idiopathic arthritis (JIA) is the most common arthritic disease of childhood and is caused by a combination of genes and environment. In the last few years great advances have been made in dissecting the genetic basis of JIA with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec4483760571e0e0adf758370e15456b
https://doi.org/10.1136/annrheumdis-2015-eular.3887

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OP0213 Identification of common susceptibility loci for inflammatory arthritis

Autor: Sampath Prahalad, Susan D. Thompson, Wendy Thomson, Anne Barton, C. Langefeld, Anne Hinks, Peter Haas, John Bowes, J Cobb, K. Steel

Publikováno v: Annals of the Rheumatic Diseases. 71:128.1-128

Background One of the principal findings of genome wide association studies in autoimmune diseases has been the substantial overlap of genetic susceptibility loci identified. This has underpinned fine mapping initiatives such as the Immunochip (IC) p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0022ebb53e63841642838cbc21744fe8
https://doi.org/10.1136/annrheumdis-2012-eular.1896

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Anti-Epileptic Drug Use and Outcome in the Ethnic and Racial Variations in Intracerebral Hemorrhage (ERICH) Study (S23.005)

Autor: K. Sheth, S. Koch, M. Elkind, G. Sung, S. Kittner, M. Frankel, J. Rosand, C. Langefeld, M. Comeau, S. Waddy, J. Osborne, D. Woo, null For the ERICH Investigators

Publikováno v: Neurology. 78:S23.005-S23.005

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8f9665023f1188dbfd04224e399d01a
https://doi.org/10.1212/wnl.78.1_meetingabstracts.s23.005

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Mortality prediction and interval until death in near-term and term neonates with respiratory failure

Autor: W A, Engle, E A, Peters, S K, Gunn, K W, West, C, Langefeld, S L, Hui

Publikováno v: Journal of perinatology : official journal of the California Perinatal Association. 13(5)

Mortality risk indicators may be useful adjuncts to clinical judgment in considering the use of extraordinary and relatively high-risk treatments such as high-frequency ventilation, extracorporeal membrane oxygenation, and nitric oxide therapy. We re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a55eed4293212110eac5b28f13f84268
https://pubmed.ncbi.nlm.nih.gov/8263621

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