Výsledky vyhledávání - "C L Vandewalle"

Increased Prevalence of Abnormal Immunoglobulin M, G, and A Concentrations at Clinical Onset of Insulin-Dependent Diabetes Mellitus

Autor: Daniel Pipeleers, Frans Gorus, C L Vandewalle, Francine Lebleu, Françoise Fery, Bart Keymeulen, Bart Van Der Auwera, Frederic Winnock, Alberto Falorni, Harry Dorchy

Publikováno v: Pancreas. 16:50-59

In view of the reported association of insulin-dependent diabetes mellitus (IDDM) with viral infections, (non-) islet-specific immune changes, and partial immunodeficiencies, we used immunonephelometry to measure circulating levels of IgM, IgG, and I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8fb2603f5cbd5f8d334ff5cfc91630a
https://doi.org/10.1097/00006676-199801000-00009

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Epidemiology, Clinical Aspects, and Biology of IDDM Patients Under Age 40 Years: Comparison of data from Antwerp with complete ascertainment with data from Belgium with 40% ascertainment. The Belgian Diabetes Registry

Autor: M. V. L. Du Caju, C L Vandewalle, M I Coeckelberghs, I. De Leeuw, F. K. Gorus, Frans Schuit, Daniel Pipeleers

Publikováno v: Diabetes Care. 20:1556-1561

OBJECTIVE To compare the incidence rate of IDDM in the age-groups 0–14 and 15–39 years in Antwerp, Belgium, and to compare demographic, clinical, and biological data from Antwerp IDDM patients with 92% ascertainment with those from a larger Belgi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::463b1993564faa2e0feba720c86f67b2
https://doi.org/10.2337/diacare.20.10.1556

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21-hydroxylase autoantibodies in adult patients with endocrine autoimmune diseases are highly specific for Addison's disease

Autor: F. K. Gorus, C L Vandewalle, Paolo Brunetti, Alberto Falorni, Holger Luthman, M. L. Picchio, B Hallengren, Cristina Tortoioli, Andrej Nikoshkov, Stefano Laureti, Fausto Santeusanio

Publikováno v: Clinical and Experimental Immunology. 107:341-346

SUMMARY The diagnostic specificity of recombinant 21-hydroxylase autoantibodies (21OH-Ab) for Addison's disease was tested in adult patients with either Graves' disease (GD), insulin-dependent diabetes mellitus (IDDM), or polyendocrinopathy, as well

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f55e9a4529552946b8e2e38fb74ec118
https://doi.org/10.1111/j.1365-2249.1997.262-ce1153.x

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IA-2-autoantibodies complement GAD 65 -autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings

Autor: André Scheen, F. K. Gorus, C. Semakula, Michael R. Christie, J. De Schepper, Patrick Goubert, Daniel Pipeleers, C L Vandewalle

Publikováno v: Diabetologia. 40:95-99

IA-2 has been identified as an autoantigen that is recognized by immunoglobulins from insulin-dependent diabetic (IDDM) patients. Using a liquid phase radiobinding assay, we performed an IA-2-autoantibody (IA-2-Ab) assay in 474 IDDM patients and 482

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ac93ca03ade6512eab18ac282a4b2a5
https://doi.org/10.1007/s001250050648

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The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry

Publikováno v: Human Molecular Genetics. 5:1075-1080

Susceptibility to autoimmune insulin-dependent (type 1) diabetes mellitus is determined by a combination of environmental and genetic factors, which include variation in MHC genes on chromosome 6p21 (IDDM1) and the insulin gene on chromosome 11p15 (I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c2dcc40d1fb5e38df7ff691bc17f02
https://doi.org/10.1093/hmg/5.7.1075

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Abnormal Circulating Pancreatic Enzyme Activities in More than Twenty-Five Percent of Recent-Onset Insulin-Dependent Diabetic Patients

Autor: M. Craen, F. K. Gorus, J. C. Sodoyez, Frans Schuit, C. Van Schravendijk, C. Semakula, Daniel Pipeleers, P. Decraene, C L Vandewalle, Andre Foriers, Alberto Falorni

Publikováno v: Pancreas. 12:321-333

Pancreatic amylase and lipase activities were measured in sera of 307 Caucasian insulin-dependent diabetes mellitus patients (IDDM) at clinical onset, 303 nondiabetic siblings of registered patients, and 207 control subjects under age 40 years. In al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7876cbd8bd0233cf65c76da5699b9a21
https://doi.org/10.1097/00006676-199605000-00001

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Insulin autoantibodies and high titre islet cell antibodies are preferentially associated with the HLA DQA1*0301-DQB1*0302 haplotype at clinical onset of Type 1 (insulin-dependent) diabetes mellitus before age 10 years, but not at onset between age 10 and 40 years

Autor: F. K. Gorus, Frans Schuit, C L Vandewalle, Daniel Pipeleers, I. De Leeuw, T. Decraene

Publikováno v: Diabetologia. 36:1155-1162

Demographic and biological data were collected from all Caucasian Type 1 diabetic patients (n = 279) who were recruited at clinical onset by the Belgian Diabetes Registry over 34 months. The male/female ratio was significantly higher for onset betwee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2fe6648127001b7a35c7546a28e14339
https://doi.org/10.1007/bf00401060

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Increased Concentrations of Total IgM At Clinical Onset of Type 1 (Insulin-Dependent) Diabetes: Correlation with IgM Binding to Cells. The Belgian Diabetes Registry

Autor: Frans Gorus, C L Vandewalle, T. Decraene, Daniel Pipeleers

Publikováno v: Vrije Universiteit Brussel

Eighty patients with type 1 (insulin-dependent) diabetes (ages 0-39 years) were consecutively recruited by the Belgian Diabetes Registry. Sera obtained at clinically diagnosed onset (i.e., before start of insulin therapy or within 7 days of initial t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::506b2bf76d4b024c549c8ef0f2e4c069
https://doi.org/10.1093/clinchem/38.9.1762

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Associations of GAD65- and IA-2- autoantibodies with genetic risk markers in new-onset IDDM patients and their siblings. The Belgian Diabetes Registry

Autor: Åke Lernmark, Frans Gorus, Frans Schuit, Patrick Goubert, Alberto Falorni, L Kaufman, Harry Dorchy, Daniel Pipeleers, C L Vandewalle, C. Semakula, Bart Van Der Auwera, Willy Coucke

Publikováno v: Diabetes care. 20(10)

OBJECTIVE To investigate the association of GAD (65-kDa) autoantibodies (GAD65-Abs) and IA-2 autoantibodies (IA-2-Abs) with human leukocyte antigen (HLA)-DQ and insulin gene (INS) risk markers in patients with recent-onset IDDM and their siblings. RE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ccab6e1528ea2c99c2cc89c31b2822b
https://pubmed.ncbi.nlm.nih.gov/9314633

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CTLA-4 gene polymorphism confers susceptibility to insulin-dependent diabetes mellitus (IDDM) independently from age and from other genetic or immune disease markers

Autor: C L Vandewalle, G. Lamberigts, F. K. Gorus, I. De Leeuw, Frans Schuit, S Van Imschoot, B. Van der Auwera, Frederic Winnock

Publikováno v: Clinical and experimental immunology

SUMMARY Apart from genes in the HLA complex (IDDM1) and the variable number of tandem repeats in the 5′ region of the insulin gene (INS VNTR, IDDM2), several other loci have been proposed to contribute to IDDM susceptibility. Recently, linkage and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d96fb8cdf37eb8bf5c396a29254c1d0a
https://europepmc.org/articles/PMC1904800/

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