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MTS-32 monoclonal antibody defines CD4+8- thymocyte subsets that differ in their maturation level, lymphokine secretion, and selection patterns

Autor: A Vicari, O Abehsira-Amar, M Papiernik, R L Boyd, C L Tucek

Publikováno v: The Journal of Immunology. 152:2207-2213

We have previously described MTS-32 as identifying an Ag on both thymic stromal cells and thymocytes. In contrast with CD4+8+ and CD4-8+ thymocytes, of which the vast majority are MTS-32+, a notable subset of CD4+8- thymocytes is MTS-32-. Here we sho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af39dd082039233187825e9edaad40e2
https://doi.org/10.4049/jimmunol.152.5.2207

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A kinetic study on the deletion of thymic, peripheral, and gut-associated V beta 6+ T cells in an Mls-1b BALB/c colony infected with an exogenous mouse mammary tumor virus

Autor: C L Tucek, C Desaymard, M Papiernik

Publikováno v: The Journal of Immunology. 151:759-766

Mls-1a expression results in the deletion of T cells bearing V beta 6 chains of the TCR. However, V beta 6+ T cells are also deleted in Mls-1b BALB/c mice that have been infected with an exogenous mouse mammary tumor virus (swiss mice) via maternal m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7274416452cc2859d99e37ab2ae20405
https://doi.org/10.4049/jimmunol.151.2.759

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Tissue distribution of Mtv-7-like exogenous retroviral transcripts and clonal deletion of Vβ6+ T cells in MIs-1b BALB/c mice

Autor: Catherine Desaymard, Alan J. Korman, Benedita Rocha, C L Tucek, Martine Papiernik

Publikováno v: International Immunology. 5:217-222

We have previously described an Mls-1a-like clonal deletion of mature CD4+ T cells which express V beta 6 and V beta 8.1 chains of the TCR in half of the mice of a BALB/c, Mls-1b colony (BALB/c IC). This occurs in the absence of the Mtv-7 provirus wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a74b420a590e8e906abf8c6597c8c1
https://doi.org/10.1093/intimm/5.2.217

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Premature TCR alpha beta expression and signaling in early thymocytes impair thymocyte expansion and partially block their development

Autor: H. D. Lacorazza, Ljiljana V. Vasovic, Janko Nikolich-Zugich, Kristin Remus, C L Tucek-Szabo

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 166(5)

In thymocyte ontogeny, Tcr-a genes rearrange after Tcr-b genes. TCR alpha beta transgenic (Tg) mice have no such delay, consequently expressing rearranged TCR alpha beta proteins early in the ontogeny. Such mice exhibit reduced thymic cellularity and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d54d816ab7d2dd840fdd9d0bb09d971c
https://pubmed.ncbi.nlm.nih.gov/11207271

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Surface T cell Fas receptor/CD95 regulation, in vivo activation, and apoptosis. Activation-induced death can occur without Fas receptor

Autor: C L, Tucek-Szabo, S, Andjelić, E, Lacy, K B, Elkon, J, Nikolić-Zugić

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 156(1)

Fas-mediated apoptosis is a form of cell death that operates through a receptor-ligand interaction. The FasR has been implicated directly in peripheral T cell tolerance and activation-induced apoptosis of T cells in vitro, although to date its expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dfa873139dfa7a9f5252b9dcd97d5347
https://pubmed.ncbi.nlm.nih.gov/8598462

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MTS-32 monoclonal antibody defines CD4+8- thymocyte subsets that differ in their maturation level, lymphokine secretion, and selection patterns

Autor: A, Vicari, O, Abehsira-Amar, M, Papiernik, R L, Boyd, C L, Tucek

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 152(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::06585495408e7d4070049b02d218a334
https://pubmed.ncbi.nlm.nih.gov/7907634

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The thymic microenvironment

Autor: Dale I. Godfrey, Mary A. Ritter, D J Izon, Trevor J. Wilson, Heather M. Ladyman, Andrew G. D. Bean, Richard L. Boyd, Natalie J. Davidson, Patrice Hugo, C L Tucek

Publikováno v: Immunology today. 14(9)

The thymus has been recognized as a site of primary immune function for more than three decades and yet, despite intense research, many of the central questions regarding its function in T-lymphocyte maturation have remained unanswered. Current cellu

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https://pubmed.ncbi.nlm.nih.gov/7515245

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A kinetic study on the deletion of thymic, peripheral, and gut-associated V beta 6+ T cells in an Mls-1b BALB/c colony infected with an exogenous mouse mammary tumor virus

Autor: C L, Tucek, C, Desaymard, M, Papiernik

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 151(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::054689cb9e1f39e23017c8fbd0d79faa
https://pubmed.ncbi.nlm.nih.gov/8101538

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Thymic shared antigen-1. A novel thymocyte marker discriminating immature from mature thymocyte subsets

Autor: D I, Godfrey, M, Masciantonio, C L, Tucek, M A, Malin, R L, Boyd, P, Hugo

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 148(7)

In a previous study, we raised a mAb (MTS 35) reacting with a plasma membrane Ag expressed on both cortical thymocytes and a subset of thymic medullary epithelial cells. In view of the shared expression of this molecule, we have defined it as thymic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fa4891b877ed1677937f34d91d0a2002
https://pubmed.ncbi.nlm.nih.gov/1531995

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