Clinical outcomes, predictors of prognosis and health economics consequences in IBD patients after discontinuation of the first biological therapy

Autor: Uday N. Shivaji, Alina Bazarova, Tamsin Critchlow, Samuel C. L. Smith, Olga Maria Nardone, Melanie Love, Joanne Davis, Subrata Ghosh, Marietta Iacucci

Publikováno v: Therapeutic Advances in Gastroenterology, Vol 13 (2020)

Background: In real-world clinical practice, biologics in inflammatory bowel diseases (IBD) may be discontinued for a variety of reasons, including discontinuation initiated by gastroenterologists. The aims of the study are to report outcomes after d

Externí odkaz: https://doaj.org/article/7af2919111884c64b8d47cf70d8456ac

Host shifts result in parallel genetic changes when viruses evolve in closely related species.

Autor: Ben Longdon, Jonathan P Day, Joel M Alves, Sophia C L Smith, Thomas M Houslay, John E McGonigle, Lucia Tagliaferri, Francis M Jiggins

Publikováno v: PLoS Pathogens, Vol 14, Iss 4, p e1006951 (2018)

Host shifts, where a pathogen invades and establishes in a new host species, are a major source of emerging infectious diseases. They frequently occur between related host species and often rely on the pathogen evolving adaptations that increase thei

Externí odkaz: https://doaj.org/article/0c3640a2bf4c44c0b065d9ec2f28ecb3

Computer-Aided Imaging Analysis of Probe-Based Confocal Laser Endomicroscopy With Molecular Labeling and Gene Expression Identifies Markers of Response to Biological Therapy in IBD Patients: The Endo-Omics Study

Autor: Marietta Iacucci, Louisa Jeffery, Animesh Acharjee, Enrico Grisan, Andrea Buda, Olga M Nardone, Samuel C L Smith, Nunzia Labarile, Davide Zardo, Bella Ungar, Stuart Hunter, Ren Mao, Rosanna Cannatelli, Uday N Shivaji, Tommaso Lorenzo Parigi, Gary M Reynolds, Georgios V Gkoutos, Subrata Ghosh

Publikováno v: Inflammatory Bowel Diseases.

Background We aimed to predict response to biologics in inflammatory bowel disease (IBD) using computerized image analysis of probe confocal laser endomicroscopy (pCLE) in vivo and assess the binding of fluorescent-labeled biologics ex vivo. Addition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d72e5dd04b560ab82a65558628fa1de7
https://doi.org/10.1093/ibd/izac233

Progenitor and close-in Circumstellar Medium of Type II Supernova 2020fqv from high-cadence photometry and ultra-rapid UV spectroscopy

Autor: Saurabh Jha, Erika Strasburger, Tiara Hung, Armin Rest, C. Jiménez-Ángel, Alexander Messick, Karoli Clever, J. D. R. Pierel, Mansi M. Kasliwal, Anthony L. Piro, David O. Jones, Wynn V. Jacobson-Galán, Charles D. Kilpatrick, Georgios Dimitriadis, Frédérick Poidevin, Qinan Wang, Raffaella Margutti, Anna M. Moore, Matthew R. Siebert, Enrico Ramirez-Ruiz, Yossef Zenati, Richard J. Wainscoat, Ryan J. Foley, K. C. Chambers, Samaporn Tinyanont, Lindsay DeMarchi, R. Ridden-harper, C L Smith, R. Shirley, Alexander Gagliano, Jonathan J. Swift, Matthew J. Hankins, Chien-Cheng Lin, Rui Marques-Chaves, Ismael Perez-Fournon, Kaushik De, Viktoriya Morozova, David A. Coulter

Publikováno v: Tinyanont, S, Ridden-Harper, R, Foley, RJ, Morozova, O V, Kilparrick, C D, Dimitriadis, G, Demarchi, L, Gagliano, A, Jacobson-Galan, W V, Messick, A, Pierel, J D R, Ramirez-Ruiz, J E, Siebert, M R, Chambers, K C, Clever, K E, Coulter, D A, Hankins, M, Lin, CC, Margutti, R, Wang, Q & Zenati, Y 2022, ' Progenitor and close-in Circumstellar Medium of Type II Supernova 2020fqv from high-cadence photometry and ultra-rapid UV spectroscopy ', Monthly Notices of the Royal Astronomical Society, vol. 512, no. 2, pp. 2777-2797 . https://doi.org/10.1093/mnras/stab2887

We present observations of SN 2020fqv, a Virgo-cluster Type II core-collapse supernova (CCSN) with a high temporal resolution light curve from the Transiting Exoplanet Survey Satellite (TESS) covering the time of explosion; ultraviolet (UV) spectrosc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba0d8216b9e2606aea686c8f9c0a694
https://curis.ku.dk/portal/da/publications/progenitor-and-closein-circumstellar-medium-of-type-ii-supernova-2020fqv-from-highcadence-photometry-and-ultrarapid-uv-spectroscopy(df3660f3-a83c-4697-bb8e-31c3f75457fd).html

The causes and consequences of changes in virulence following pathogen host shifts.

Autor: Ben Longdon, Jarrod D Hadfield, Jonathan P Day, Sophia C L Smith, John E McGonigle, Rodrigo Cogni, Chuan Cao, Francis M Jiggins

Publikováno v: PLoS Pathogens, Vol 11, Iss 3, p e1004728 (2015)

Emerging infectious diseases are often the result of a host shift, where the pathogen originates from a different host species. Virulence--the harm a pathogen does to its host-can be extremely high following a host shift (for example Ebola, HIV, and

Externí odkaz: https://doaj.org/article/46837244bc0e4d5dbf1f2d00897c3b3c