Zobrazeno 1 - 10
of 20
pro vyhledávání: '"C L Morton"'
Publikováno v:
Gut. 31:311-316
Mucosal histology, crypt cell proliferation and brush border enzymes were measured in rats with varying degrees of jejunoileal bypass, in order to compare the effect of systemic and luminal factors on adaptive growth and differentiation (brush border
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01179d93318d1b097c5e2c49116502e2
https://doi.org/10.1136/gut.31.3.311
https://doi.org/10.1136/gut.31.3.311
Publikováno v:
Cancer research. 61(13)
Irinotecan, 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) is activated by carboxylesterases (CE) to yield the potent topoisomerase I inhibitor, SN-38. We have demonstrated previously that a rabbit liver CE is approximatel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::17d9c38e3b0e3d34e5b6a72f87c1a72b
https://pubmed.ncbi.nlm.nih.gov/11431344
https://pubmed.ncbi.nlm.nih.gov/11431344
Publikováno v:
Cancer research. 60(17)
Irinotecan [7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11)] is metabolized by esterases to yield the potent topoisomerase I poison 7-ethyl-10-hydroxycamptothecin. One of the major side effects observed with CPT-11 is gastr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8fe96bb0666238c1883debccf8f4fa72
https://pubmed.ncbi.nlm.nih.gov/10987276
https://pubmed.ncbi.nlm.nih.gov/10987276
Autor:
C L, Morton, M, Wierdl, L, Oliver, M K, Ma, M K, Danks, C F, Stewart, J L, Eiseman, P M, Potter
Publikováno v:
Cancer research. 60(15)
The camptothecin prodrug CPT-11 (irinotecan, 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin) is converted by esterases to yield the potent topoisomerase I poison SN-38 (7-ethyl-10-hydroxycamptothecin). Recently, a mouse strain (Es1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d5a5fc07b5bd389ce1baeafc92c431d5
https://pubmed.ncbi.nlm.nih.gov/10945631
https://pubmed.ncbi.nlm.nih.gov/10945631
Publikováno v:
Biochemical pharmacology. 59(7)
Butyrylcholinesterases (BuChEs; acylcholine acylhydrolase; EC 3.1.1.8) have been demonstrated to convert the anticancer agent CPT-11 (irinotecan, 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin) into its active metabolite SN-38 (7-e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7142e81b54ba61482a442ce54b1610da
https://pubmed.ncbi.nlm.nih.gov/10718335
https://pubmed.ncbi.nlm.nih.gov/10718335
Autor:
M K, Danks, C L, Morton, E J, Krull, P J, Cheshire, L B, Richmond, C W, Naeve, C A, Pawlik, P J, Houghton, P M, Potter
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 5(4)
Several recent studies have examined the possibility of producing tumor-specific cytotoxicity with various enzyme/ prodrug combinations. The enzymes are targeted to tumor cells either with antibodies (ADEPT, antibody directed enzyme prodrug therapy)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::87c95de52649066d15612b2bd95c483a
https://pubmed.ncbi.nlm.nih.gov/10213229
https://pubmed.ncbi.nlm.nih.gov/10213229
Publikováno v:
Cancer research. 59(7)
Patients treated with high doses of CPT-11 rapidly develop a cholinergic syndrome that can be alleviated by atropine. Although CPT-11 was not a substrate for acetylcholinesterase (AcChE), in vitro assays confirmed that CPT-11 inhibited both human and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2003f0dd95d72d959622f08b5e9ae07e
https://pubmed.ncbi.nlm.nih.gov/10197614
https://pubmed.ncbi.nlm.nih.gov/10197614
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 4(12)
The anticancer drug CPT-11 (7-ethyl-[4(1-piperidino)-1-piperidino]carbonyloxycamptothecin) is a water-soluble derivative of camptothecin. We report here the conversion of APC (7-ethyl-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1c047df82c29e1141e4865018053a87d
https://pubmed.ncbi.nlm.nih.gov/9865925
https://pubmed.ncbi.nlm.nih.gov/9865925
Publikováno v:
Cancer research. 58(16)
Enzyme activation of prodrugs to improve the therapeutic index of specific anticancer agents is an attractive alternative to current chemotherapy regimens. This study addresses the potential for activating irinotecan (CPT-11) with recombinant carboxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c102d15eb7783bbc224cf205bd6e2468
https://pubmed.ncbi.nlm.nih.gov/9721871
https://pubmed.ncbi.nlm.nih.gov/9721871
Autor:
C L, Morton, P M, Potter
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 286(2)
We examined a panel of cell lines for the expression of the myogenic proteins myoD and myogenin. High level expression of both proteins was seen in rhabdomyosarcoma (RMS). To determine whether promoter elements from these genes could direct RMS cell-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aa65c369cab00dc097c8db188927c1b8
https://pubmed.ncbi.nlm.nih.gov/9694970
https://pubmed.ncbi.nlm.nih.gov/9694970