Rhabdoid Tumor of the Kidney and Soft Tissues: Results from National Wilms Tumor Study-5 and Children's Oncology Group Study AREN0321.

Autor: Geller JI; Division of Pediatric Oncology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA., Renfro LA; Division of Biostatistics, University of Southern California and Children's Oncology Group, Los Angeles, California, USA., Grundy PE; Division of Immunology, Hematology, Oncology, Palliative Care, and Environmental Interactions, University of Alberta, Edmonton, Alberta, Canada., Perlman EJ; Department of Pathology and Laboratory Medicine, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Kalapurakal JA; Department of Radiation Oncology, Northwestern University, Chicago, Illinois, USA., Ehrlich PF; Section of Pediatric Surgery, CS Mott Children's Hospital, University of Michigan, Ann Arbor, Michigan, USA., Biegel J; Keck School of Medicine, University of Southern California, Los Angeles, California, USA.; Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, California, USA., Huff V; Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Warwick AB; Department of Pediatrics, F. Edward Hébert School of Medicine, Uniformed Services University, Bethesda, Maryland, USA., Paulino A; MD Anderson Cancer Center, Houston, Texas, USA., Mullen EA; Boston Children's Hospital and Dana Farber Cancer Institute, Boston, Massachusetts, USA., Daw NC; Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Hoffer FA; Department of Radiology, Fred Hutchison Cancer Center, University of Washington, Seattle, Washington, USA., Tochner Z; Department of Radiation Oncology, Perelman Center for Advanced Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA., Gow K; Division of Pediatric General and Thoracic Surgery, Seattle Children's Hospital, University of Washington, Seattle, Washington, USA., Gratias E; eviCore Healthcare, Bluffton, South Carolina, USA., Ward DA; Department of Pharmaceutical Services, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Anderson JR; University of Nebraska Medical Center, Omaha, Nebraska, USA., Fernandez CV; Division of Pediatric Hematology Oncology, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada., Dome JS; Division of Oncology, Children's National Hospital and Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA.

Publikováno v: Pediatric blood & cancer [Pediatr Blood Cancer] 2024 Dec 19, pp. e31490. Date of Electronic Publication: 2024 Dec 19.

Sensitization of human tumor cells to CPT-11 via adenoviral-mediated delivery of a rabbit liver carboxylesterase

Autor: M, Wierdl, C L, Morton, J K, Weeks, M K, Danks, L C, Harris, P M, Potter

Publikováno v: Cancer research. 61(13)

Irinotecan, 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) is activated by carboxylesterases (CE) to yield the potent topoisomerase I inhibitor, SN-38. We have demonstrated previously that a rabbit liver CE is approximatel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::17d9c38e3b0e3d34e5b6a72f87c1a72b
https://pubmed.ncbi.nlm.nih.gov/11431344

Activation of CPT-11 in mice: identification and analysis of a highly effective plasma esterase

Autor: C L, Morton, M, Wierdl, L, Oliver, M K, Ma, M K, Danks, C F, Stewart, J L, Eiseman, P M, Potter

Publikováno v: Cancer research. 60(15)

The camptothecin prodrug CPT-11 (irinotecan, 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin) is converted by esterases to yield the potent topoisomerase I poison SN-38 (7-ethyl-10-hydroxycamptothecin). Recently, a mouse strain (Es1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d5a5fc07b5bd389ce1baeafc92c431d5
https://pubmed.ncbi.nlm.nih.gov/10945631

Comparison of activation of CPT-11 by rabbit and human carboxylesterases for use in enzyme/prodrug therapy

Autor: M K, Danks, C L, Morton, E J, Krull, P J, Cheshire, L B, Richmond, C W, Naeve, C A, Pawlik, P J, Houghton, P M, Potter

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 5(4)

Several recent studies have examined the possibility of producing tumor-specific cytotoxicity with various enzyme/ prodrug combinations. The enzymes are targeted to tumor cells either with antibodies (ADEPT, antibody directed enzyme prodrug therapy)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::87c95de52649066d15612b2bd95c483a
https://pubmed.ncbi.nlm.nih.gov/10213229

Conversion of the CPT-11 metabolite APC to SN-38 by rabbit liver carboxylesterase

Autor: S M, Guichard, C L, Morton, E J, Krull, C F, Stewart, M K, Danks, P M, Potter

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 4(12)

The anticancer drug CPT-11 (7-ethyl-[4(1-piperidino)-1-piperidino]carbonyloxycamptothecin) is a water-soluble derivative of camptothecin. We report here the conversion of APC (7-ethyl-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1c047df82c29e1141e4865018053a87d
https://pubmed.ncbi.nlm.nih.gov/9865925