Zobrazeno 1 - 10
of 11
pro vyhledávání: '"C L Mackall"'
Publikováno v:
The Journal of Immunology. 156:4609-4616
Thymic regenerative capacity in humans decreases with age, suggesting that thymic-independent pathways of T cell regeneration may predominate during adulthood. Using a murine bone marrow transplantation model, we present evidence that thymic-independ
Autor:
M Christ, N L McCartney-Francis, A B Kulkarni, J M Ward, D E Mizel, C L Mackall, R E Gress, K L Hines, H Tian, S Karlsson
Publikováno v:
The Journal of Immunology. 153:1936-1946
Approximately 2 wk after birth, mice having a TGF-beta 1 null mutation (TGF-beta 1(-/-)) exhibit a progressive wasting syndrome and death. Associated with this phenotype is a multifocal infiltration of lymphocytes and macrophages into target organs,
Autor:
C L, Mackall, D, Stein, T A, Fleisher, M R, Brown, F T, Hakim, C V, Bare, S F, Leitman, E J, Read, C S, Carter, L H, Wexler, R E, Gress
Publikováno v:
Blood. 96(2)
Administration of mobilized peripheral blood progenitor cells (PBPCs) after high-dose chemotherapy rapidly restores multilineage hematopoiesis, but the ability of such products to restore lymphocyte populations remains unclear. In this report, we eva
Publikováno v:
Cancer research. 58(24)
Fas-Fas ligand interactions play a central role in the regulation of the immune response. Fas ligand expression by tumors has been implicated in the abrogation of the host antitumor response by killing of Fas-positive effector lymphocytes. We have st
Publikováno v:
European journal of immunology. 28(6)
Age-associated thymic involution results in a diminished capacity to regenerate T cell populations, although the magnitude of this effect is unknown. In this report, thymic function was studied in aged vs. young adult mice after lethal irradiation an
Publikováno v:
Blood. 90(9)
To examine the mechanisms of CD4 reconstitution in an adult population, lymphocyte repopulation was assessed following dose-intense chemotherapy in 25 breast cancer patients, ages 33 to 69 years. Chemotherapy resulted in a greater than 60% reduction
Autor:
C L, Mackall, T A, Fleisher, M R, Brown, M P, Andrich, C C, Chen, I M, Feuerstein, I T, Magrath, L H, Wexler, D S, Dimitrov, R E, Gress
Publikováno v:
Blood. 89(10)
Rapid recovery of CD4+ T cells after intensive chemotherapy is limited by an age-dependent decline in thymopoiesis. Here we sought to determine whether similar limitations exist for CD8+ T-cell regeneration. After intensive chemotherapy, CD8+ T cells
Autor:
T A, Borkowski, J J, Letterio, C L, Mackall, A, Saitoh, A G, Farr, X J, Wang, D R, Roop, R E, Gress, M C, Udey
Publikováno v:
Advances in experimental medicine and biology. 417
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 156(12)
Thymic regenerative capacity in humans decreases with age, suggesting that thymic-independent pathways of T cell regeneration may predominate during adulthood. Using a murine bone marrow transplantation model, we present evidence that thymic-independ
Autor:
A B, Kulkarni, J M, Ward, L, Yaswen, C L, Mackall, S R, Bauer, C G, Huh, R E, Gress, S, Karlsson
Publikováno v:
The American journal of pathology. 146(1)
Approximately 40% of transforming growth factor-beta 1 null (knockout) mice generated in our laboratory develop normally to term, but 60% die in utero. The animals appear normal during the first 2 weeks of life but develop a rapid wasting syndrome an