Výsledky vyhledávání - "C L, Willman"

Pediatric Acute Lymphoblastic Leukemia

Autor: John C. Reed, Elizabeth A. Raetz, Mary V. Relling, Stella Davies, Dong Joon Min, Deepa Bhojwani, William L. Carroll, James R. Downing, C. L. Willman

Publikováno v: Hematology. 2003:102-131

The outcome for children with acute lymphoblastic leukemia (ALL) has improved dramatically with current therapy resulting in an event free survival exceeding 75% for most patients. However significant challenges remain including developing better met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ef58e92ad68e1543496406d4828a759
https://doi.org/10.1182/asheducation-2003.1.102

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Achievements in Understanding and Treatment of Myelodysplastic Syndromes

Autor: Yogen Saunthararajah, C. L. Willman, Eva Hellström-Lindberg, A. John Barrett

Publikováno v: Hematology. 2000:110-132

The myelodysplastic syndromes (MDS) constitute a challenge for the biologist as well as for the treating physician. In Section I, Dr. Willman reviews the current classifications and disease mechanisms involved in this heterogeneous clonal hematopoiet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d9aaeac8ec5fa9ed84402fffec390b
https://doi.org/10.1182/asheducation.v2000.1.110.110

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Characterization and Use of an Antibody Detecting the CBFβ-SMMHC Fusion Protein in inv(16)/t(16;16)-Associated Acute Myeloid Leukemias

Autor: Marilyn L. Slovak, C. Rankin, Pu Paul Liu, David S. Viswanatha, David R. Head, C. L. Willman, I-Ming Chen

Publikováno v: Blood. 91:1882-1890

The inv(16)(p13q22) and t(16;16)(p13;q22) cytogenetic abnormalities occur commonly in acute myeloid leukemia (AML), typically associated with French-American-British (FAB) AML-M4Eo subtype. Reverse transcriptase-polymerase chain reaction (RT-PCR) tec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a6e9cf1426df9523d56bfee963d53dc
https://doi.org/10.1182/blood.v91.6.1882

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An AML1/ETO fusion transcript is consistently detected by RNA-based polymerase chain reaction in acute myelogenous leukemia containing the (8;21)(q22;q22) translocation

Autor: Andrew J. Carroll, David R. Head, P. Erickson, James R. Downing, Susana C. Raimondi, A. M. Curcio-Brint, Karl S. Theil, Curt I. Civin, T. A. Motroni, M. G. Hulshof, Harry A. Drabkin, C. L. Willman

Publikováno v: Blood. 81:2860-2865

The 8;21 translocation is one of the most common chromosomal translocations in acute myelogenous leukemia (AML), accounting for 40% of pediatric AML with French-American-British (FAB)-M2 morphology. The chromosomal breakpoints have recently been iden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8396b52991e1ea536a3eb74b359fd18d
https://doi.org/10.1182/blood.v81.11.2860.2860

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False-positive flow cytometric platelet glycoprotein IIb/IIIa expression in myeloid leukemias secondary to platelet adherence to blasts

Autor: S A, Betz, K, Foucar, D R, Head, I M, Chen, C L, Willman

Publikováno v: Blood. 79:2399-2403

Because neither morphologic nor routine cytochemical features are pathognomonic, the diagnosis of acute megakaryoblastic leukemia (AML- M7) is difficult, requiring either specialized ultrastructural or immunologic techniques. Because the ultrastructu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1bd140407968c6fde510caf64b7498d
https://doi.org/10.1182/blood.v79.9.2399.bloodjournal7992399

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A retrospective study of 69 patients with t(6;9)(p23;q34) AML emphasizes the need for a prospective, multicenter initiative for rare 'poor prognosis' myeloid malignancies

Autor: Holly Gundacker, Soheil Meshinchi, Yaddanapudi Ravindranath, Richard A. Larson, Marilyn L. Slovak, John M. Bennett, Susana C. Raimondi, Clara D. Bloomfield, Todd A. Alonzo, Derek L. Stirewalt, C. L. Willman, Nyla A. Heerema, Gordon W. Dewald, Martin S. Tallman, F R Appelbaum, Andrew J. Carroll

Publikováno v: Leukemia. 20(7)

A retrospective study of 69 patients with t(6;9)(p23;q34) AML emphasizes the need for a prospective, multicenter initiative for rare ‘poor prognosis’ myeloid malignancies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbc46c76869e894f2e3dea671481d08d
https://pubmed.ncbi.nlm.nih.gov/16628187

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Twenty-four-color spectral karyotyping reveals chromosome aberrations in cytogenetically normal acute myeloid leukemia

Autor: F F, Zhang, J L, Murata-Collins, P, Gaytan, S J, Forman, K J, Kopecky, C L, Willman, F R, Appelbaum, M L, Slovak

Publikováno v: Genes, chromosomescancer. 28(3)

Multicolor spectral karyotyping allows simultaneous visualization of all human chromosomes and screening for chromosomal rearrangements without a priori knowledge of any abnormalities involved. Based on this potentially increased sensitivity, we inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::30a1b228989a5c2b10e9206b84ef84a6
https://pubmed.ncbi.nlm.nih.gov/10862038

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Glutathione S-transferase theta 1 gene deletion and risk of acute myeloid leukemia

Autor: C, Crump, C, Chen, F R, Appelbaum, K J, Kopecky, S M, Schwartz, C L, Willman, M L, Slovak, N S, Weiss

Publikováno v: Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 9(5)

Individuals with a homozygous deletion of the glutathione S-transferase theta 1 (GSTT1) gene lack GSTT1 enzymatic detoxification of environmental carcinogens by conjugation with glutathione. The GSTT1 gene deletion has been associated with carcinogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::388bdddbc59aca29170c12ae2f8efbac
https://pubmed.ncbi.nlm.nih.gov/10815689

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Acute myelogenous leukemia and aging. Clinical interactions

Autor: J E, Lancet, C L, Willman, J M, Bennett

Publikováno v: Hematology/oncology clinics of North America. 14(1)

Effective treatment of the elderly patient with AML remains a challenging task. Acute myelogenous leukemia is clearly a different disease in the elderly than in the young, for many reasons, both clinical and biologic, which contribute to the worse pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bb44aab6449d0be23c4bf686cd0378c3
https://pubmed.ncbi.nlm.nih.gov/10680081

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Molecular evaluation of acute myeloid leukemias

Autor: C L, Willman

Publikováno v: Seminars in hematology. 36(4)

Traditionally, acute myeloid leukemia (AML) has been diagnosed and classified based on the morphologic and cytochemical criteria of the French-American-British (FAB) classification system. However, more recent studies have demonstrated that the cytog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5bfbed9c7f568fc7cc86e65ea87af334
https://pubmed.ncbi.nlm.nih.gov/10530720

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