Zobrazeno 1 - 10 of 12 pro vyhledávání: '"C L, Sawyers"'
1
Abstract 5128: Polyethnic-1000: Advancing cancer genomics by studying ethnically diverse, underserved patient populations in New York
Autor: Fieke E. M. Froeling, David A. Tuveson, M. Zody, B. Hubert, Nicolas Robine, C. L. Sawyers, D. Oschwald, H. E. Varmus
Publikováno v: Cancer Research. 79:5128-5128
Background and aims Recent advances in DNA sequencing technologies have revolutionized approaches to the prevention, risk assessment, early detection, diagnosis, and treatment of cancers. However, many ethnic groups, especially non-European populatio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d439828a881e8959b53fc8659e0010e8
https://doi.org/10.1158/1538-7445.am2019-5128
Zobrazit plný text záznamu
2
Propagation of human blastic myeloid leukemias in the SCID mouse
Autor: C L, Sawyers, M L, Gishizky, S, Quan, D W, Golde, O N, Witte
Publikováno v: Blood. 79:2089-2098
Existing in vitro culture technology does not permit the routine propagation of most human myeloid leukemias. Previous work has shown the usefulness of mice with severe combined immunodeficiency (SCID) for the growth of human lymphoblastic leukemia.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f027586c067eecb1a41e774da1e3d3
https://doi.org/10.1182/blood.v79.8.2089.bloodjournal7982089
Zobrazit plný text záznamu
4
Cancer treatment in the STI571 era: what will change?
Autor: C L, Sawyers
Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 19
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5b8a32d4a612d441f108dcdbdc16d1c4
https://pubmed.ncbi.nlm.nih.gov/11560965
Zobrazit plný text záznamu
5
In vivo progression of LAPC-9 and LNCaP prostate cancer models to androgen independence is associated with increased expression of insulin-like growth factor I (IGF-I) and IGF-I receptor (IGF-IR)
Autor: T, Nickerson, F, Chang, D, Lorimer, S P, Smeekens, C L, Sawyers, M, Pollak
Publikováno v: Cancer research. 61(16)
Androgen deprivation therapies for metastatic prostate cancer are useful initially, but progression to androgen independence usually results in relapse within 2 years. The molecular mechanisms underlying the clinically important transition from andro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::73d8334c33a6ea7b676b20bec2adea9f
https://pubmed.ncbi.nlm.nih.gov/11507082
Zobrazit plný text záznamu
6
Evidence for clonal outgrowth of androgen-independent prostate cancer cells from androgen-dependent tumors through a two-step process
Autor: N, Craft, C, Chhor, C, Tran, A, Belldegrun, J, DeKernion, O N, Witte, J, Said, R E, Reiter, C L, Sawyers
Publikováno v: Cancer research. 59(19)
Prostate cancers require androgen for growth but progress to an androgen-independent stage under the selective pressure of androgen ablation therapy. Here we describe a novel human prostate cancer xenograft (LAPC-9) propagated by serial passage in ma
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7a50274716e8f71d03f0f788295fb317
https://pubmed.ncbi.nlm.nih.gov/10519419
Zobrazit plný text záznamu
7
Mechanistic concepts in androgen-dependence of prostate cancer
Autor: N, Craft, C L, Sawyers
Publikováno v: Cancer metastasis reviews. 17(4)
Androgen blockade is the mainstay of therapy in the clinical management of advanced prostate cancer. Recent progress on two fronts--the development of newer xenograft and transgenic models and a greater understanding of nuclear receptor signaling--ha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2323245c512dbf80e41c518857f3704a
https://pubmed.ncbi.nlm.nih.gov/10453286
Zobrazit plný text záznamu
9
Signal transduction pathways involved in BCR-ABL transformation
Autor: C L, Sawyers
Publikováno v: Bailliere's clinical haematology. 10(2)
BCR-ABL is an oncogenic fusion gene found in patients with chronic myelogenous leukaemia (CML) and acute lymphocytic leukaemia whose oncogenic potential has been demonstrated using in vitro and in vivo model systems. Current research efforts are focu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c5d51e93da62669f192ff8189597c7b2
https://pubmed.ncbi.nlm.nih.gov/9376661
Zobrazit plný text záznamu
10
p53 dependent growth suppression by the c-Abl nuclear tyrosine kinase
Autor: A, Goga, X, Liu, T M, Hambuch, K, Senechal, E, Major, A J, Berk, O N, Witte, C L, Sawyers
Publikováno v: Oncogene. 11(4)
Growth suppression by the Rb and p53 tumor suppressor proteins is mediated through effects on cell cycle regulatory proteins at the G1/S transition. Because overexpression of c-Abl induces G1 arrest in fibroblasts, we reasoned that c-Abl may also aff
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e41c20ba4bd7c2e85f17f31afa9a10bc
https://pubmed.ncbi.nlm.nih.gov/7651743
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje