Zobrazeno 1 - 10
of 87
pro vyhledávání: '"C L, Rivier"'
Publikováno v:
The journal of peptide research : official journal of the American Peptide Society. 65(2)
Degarelix is a potent very long-acting GnRH antagonist after subcutaneous administration. In this paper, we describe the synthesis of two analogs of degarelix incorporating racemic 3-(2-methoxy-5-pyridyl)-alanine (2-OMe-5Pal, 5) at position 3. The tw
Autor:
J E, Rivier, G, Jiang, R S, Struthers, S C, Koerber, J, Porter, L A, Cervini, D A, Kirby, A G, Craig, C L, Rivier
Publikováno v:
Journal of medicinal chemistry. 43(5)
In three earlier papers, the structures and biological potencies of numerous mono- and dicyclic antagonists of GnRH were reported. Among these, two families, each containing two to four members were identified that had very high antagonist potencies
Publikováno v:
Alcoholism, clinical and experimental research. 23(1)
Prenatal alcohol exposure has been shown to produce hyperresponsiveness of the hypothalamic-pituitary-adrenal (HPA) axis to immune challenges. Because cytokines, which are released in response to immune challenges, are known to activate the HPA axis,
Autor:
A V, Turnbull, C L, Rivier
Publikováno v:
Endocrinology. 139(1)
The present study tested the hypothesis that the cytokine tumor necrosis factor-alpha (TNF-alpha) is an important central nervous system mediator of the rat hypothalamo-pituitary-adrenal (HPA) axis response to the i.v. administration of lipopolysacch
Autor:
A V, Turnbull, C L, Rivier
Publikováno v:
Endocrinology. 139(1)
The findings of the preceding article suggest that intracerebroventricular (i.c.v.) administration of small amounts (5 microl) of antisera to rats may produce effectual immunoneutralization of peptides in blood/tissues outside of the central nervous
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 4/2/2024, Vol. 121 Issue 14, p1-8, 8p
Autor:
Ikegami, Tohru1,2 ikegami@kit.ac.jp
Publikováno v:
Journal of Separation Science. Jan2019, Vol. 42 Issue 1, p130-213. 84p.
Publikováno v:
Chemistry - A European Journal. 9/18/2017, Vol. 23 Issue 52, p12876-12885. 10p.
Autor:
Cimino, Irene, Kim, Hanna, Tung, Y. C. Loraine, Pedersen, Kent, Rimmington, Debra, Tadross, John A., Kohnke, Sara N., Neves-Costa, Ana, Barros, André, Joaquim, Stephanie, Bennett, Don, Melvin, Audrey, Lockhart, Samuel M., Rostron, Anthony J., Scott, Jonathan, Hui Liu, Burling, Keith, Barker, Peter, Clatworthy, Menna R., E-Chiang Lee
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 7/6/2021, Vol. 118 Issue 27, p1-10, 10p
Autor:
Skelly, Mary J.1, Weiner, Jeff L.1
Publikováno v:
Brain & Behavior. Jul2014, Vol. 4 Issue 4, p468-483. 16p.