Výsledky vyhledávání - "C L, Mackall"

Immune dysregulation in TGF-beta 1-deficient mice

Autor: M Christ, N L McCartney-Francis, A B Kulkarni, J M Ward, D E Mizel, C L Mackall, R E Gress, K L Hines, H Tian, S Karlsson

Publikováno v: The Journal of Immunology. 153:1936-1946

Approximately 2 wk after birth, mice having a TGF-beta 1 null mutation (TGF-beta 1(-/-)) exhibit a progressive wasting syndrome and death. Associated with this phenotype is a multifocal infiltration of lymphocytes and macrophages into target organs,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ace62b18e8d4c26b8b132de19b1b977
https://doi.org/10.4049/jimmunol.153.5.1936

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Prolonged CD4 depletion after sequential autologous peripheral blood progenitor cell infusions in children and young adults

Autor: C L, Mackall, D, Stein, T A, Fleisher, M R, Brown, F T, Hakim, C V, Bare, S F, Leitman, E J, Read, C S, Carter, L H, Wexler, R E, Gress

Publikováno v: Blood. 96(2)

Administration of mobilized peripheral blood progenitor cells (PBPCs) after high-dose chemotherapy rapidly restores multilineage hematopoiesis, but the ability of such products to restore lymphocyte populations remains unclear. In this report, we eva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a777f01fda45b5b9dde770d7720b23de
https://pubmed.ncbi.nlm.nih.gov/10887145

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Simultaneous expression of Fas and nonfunctional Fas ligand in Ewing's sarcoma

Autor: H U, Kontny, T M, Lehrnbecher, S J, Chanock, C L, Mackall

Publikováno v: Cancer research. 58(24)

Fas-Fas ligand interactions play a central role in the regulation of the immune response. Fas ligand expression by tumors has been implicated in the abrogation of the host antitumor response by killing of Fas-positive effector lymphocytes. We have st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d5c1295ccaeb9fdbfefccf193fd21b51
https://pubmed.ncbi.nlm.nih.gov/9865744

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Thymic function in young/old chimeras: substantial thymic T cell regenerative capacity despite irreversible age-associated thymic involution

Autor: C L, Mackall, J A, Punt, P, Morgan, A G, Farr, R E, Gress

Publikováno v: European journal of immunology. 28(6)

Age-associated thymic involution results in a diminished capacity to regenerate T cell populations, although the magnitude of this effect is unknown. In this report, thymic function was studied in aged vs. young adult mice after lethal irradiation an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::614c55db8d0f8b9755caacbaa56933c5
https://pubmed.ncbi.nlm.nih.gov/9645370

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Constraints on CD4 recovery postchemotherapy in adults: thymic insufficiency and apoptotic decline of expanded peripheral CD4 cells

Autor: F T, Hakim, R, Cepeda, S, Kaimei, C L, Mackall, N, McAtee, J, Zujewski, K, Cowan, R E, Gress

Publikováno v: Blood. 90(9)

To examine the mechanisms of CD4 reconstitution in an adult population, lymphocyte repopulation was assessed following dose-intense chemotherapy in 25 breast cancer patients, ages 33 to 69 years. Chemotherapy resulted in a greater than 60% reduction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d416539cc47515bf587d9c6b6cfe6f5d
https://pubmed.ncbi.nlm.nih.gov/9345067

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Distinctions between CD8+ and CD4+ T-cell regenerative pathways result in prolonged T-cell subset imbalance after intensive chemotherapy

Autor: C L, Mackall, T A, Fleisher, M R, Brown, M P, Andrich, C C, Chen, I M, Feuerstein, I T, Magrath, L H, Wexler, D S, Dimitrov, R E, Gress

Publikováno v: Blood. 89(10)

Rapid recovery of CD4+ T cells after intensive chemotherapy is limited by an age-dependent decline in thymopoiesis. Here we sought to determine whether similar limitations exist for CD8+ T-cell regeneration. After intensive chemotherapy, CD8+ T cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f9abc9f2ac2c2bf8564994b42113a1ea
https://pubmed.ncbi.nlm.nih.gov/9160675

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Langerhans cells in the TGF beta 1 null mouse

Autor: T A, Borkowski, J J, Letterio, C L, Mackall, A, Saitoh, A G, Farr, X J, Wang, D R, Roop, R E, Gress, M C, Udey

Publikováno v: Advances in experimental medicine and biology. 417

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c75e66b5b8dd8e45500a59e361c081f7
https://pubmed.ncbi.nlm.nih.gov/9286378

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Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing

Autor: C L, Mackall, C V, Bare, L A, Granger, S O, Sharrow, J A, Titus, R E, Gress

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 156(12)

Thymic regenerative capacity in humans decreases with age, suggesting that thymic-independent pathways of T cell regeneration may predominate during adulthood. Using a murine bone marrow transplantation model, we present evidence that thymic-independ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3b39e21b4c36721804d560c9d07eab8e
https://pubmed.ncbi.nlm.nih.gov/8648103

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Transforming growth factor-beta 1 null mice. An animal model for inflammatory disorders

Autor: A B, Kulkarni, J M, Ward, L, Yaswen, C L, Mackall, S R, Bauer, C G, Huh, R E, Gress, S, Karlsson

Publikováno v: The American journal of pathology. 146(1)

Approximately 40% of transforming growth factor-beta 1 null (knockout) mice generated in our laboratory develop normally to term, but 60% die in utero. The animals appear normal during the first 2 weeks of life but develop a rapid wasting syndrome an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::32d80d5459da382a625a0200ae465ecb
https://pubmed.ncbi.nlm.nih.gov/7856732

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